Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer

The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200

(2017) Muhammad Zaeem Noman et al.   OncoImmunology

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer

(2016) Aiman Z. Elmansuri et al.   Oncotarget

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance

(2015) Willy Hugo et al.   CELL

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

(2015) S. Loi et al.   CLINICAL CANCER RESEARCH

Novel Roles of c-Met in the Survival of Renal Cancer Cells through the Regulation of HO-1 and PD-L1 Expression

(2015) Murugabaskar Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRK proteins selectively regulate T cell migration into inflamed tissues

(2015) Yanping Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation

(2015) Nan Chen et al.   Journal of Thoracic Oncology

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

(2015) Abdullah Alsuliman et al.   Molecular Cancer

Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

(2015) Tamjeed Saleh et al.   Nature Chemical Biology

Prognostic and predictive value of PDL1 expression in breast cancer

(2015) Renaud Sabatier et al.   Oncotarget

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

Crk at the Quarter Century Mark: Perspectives in Signaling and Cancer

(2013) Sushil Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

The Adaptor Protein Crk Controls Activation and Inhibition of Natural Killer Cells

(2012) Dongfang Liu et al.   IMMUNITY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling

(2009) Raymond B Birge et al.   Cell Communication and Signaling

A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors

(2008) S. Antoku et al.   JOURNAL OF CELL SCIENCE

Direct multiplexed measurement of gene expression with color-coded probe pairs

(2008) Gary K Geiss et al.   NATURE BIOTECHNOLOGY