IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness

(2015) Helge Siemens et al.   Oncotarget

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition

(2013) Stefanie Hahn et al.   EMBO JOURNAL

The Gastrointestinal Tumor Microenvironment

(2013) Michael Quante et al.   GASTROENTEROLOGY

AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer

(2013) Rene Jackstadt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trp53 Deficiency Protects against Acute Intestinal Inflammation

(2013) M. E. Spehlmann et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Improves Sca-1+Stem Cell Survival and Directs Ischemic Cardiomyocytes Toward a Prosurvival Phenotype Via Exosomal Transfer: A Critical Role for HSF1/miR-34a/HSP70 Pathway

(2013) Yuliang Feng et al.   STEM CELLS

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

microRNA involvement in human cancer

(2012) M. V. Iorio et al.   CARCINOGENESIS

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

MiR-34 and SNAIL: Another double-negative feedback loop controlling cellular plasticity/EMT governed by p53

(2012) Thomas Brabletz   CELL CYCLE

Detection of miR-34a Promoter Methylation in Combination with Elevated Expression of c-Met and  -Catenin Predicts Distant Metastasis of Colon Cancer

(2012) H. Siemens et al.   CLINICAL CANCER RESEARCH

IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6

(2012) Stefan Rose-John   International Journal of Biological Sciences

IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis

(2012) Matjaz Rokavec et al.   MOLECULAR CELL

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

(2011) S. I. Grivennikov et al.   ANNALS OF THE RHEUMATIC DISEASES

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

(2011) Hua Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

IL-6 Promotes Head and Neck Tumor Metastasis by Inducing Epithelial-Mesenchymal Transition via the JAK-STAT3-SNAIL Signaling Pathway

(2011) A. Yadav et al.   MOLECULAR CANCER RESEARCH

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

(2011) G Mudduluru et al.   ONCOGENE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Doubles Game: Src-Stat3 versus p53-PTEN in Cellular Migration and Invasion

(2010) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

(2009) N R Christoffersen et al.   CELL DEATH AND DIFFERENTIATION

Binding reactions: epigenetic switches, signal transduction and cancer

(2009) Mark Ptashne   CURRENT BIOLOGY

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Metabolic defects provide a spark for the epigenetic switch in cancer

(2009) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serum interleukin-6 levels in colorectal cancer patients—a summary of published results

(2009) Heike Knüpfer et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Essential Roles of IL-6 Trans-Signaling in Colonic Epithelial Cells, Induced by the IL-6/Soluble-IL-6 Receptor Derived from Lamina Propria Macrophages, on the Development of Colitis-Associated Premalignant Cancer in a Murine Model

(2009) S. Matsumoto et al.   JOURNAL OF IMMUNOLOGY

The morphological and molecular features of the epithelial-to-mesenchymal transition

(2009) Gema Moreno-Bueno et al.   Nature Protocols

miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

(2008) Na Li et al.   CANCER LETTERS

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Snail Up-regulates Proinflammatory Mediators and Inhibits Differentiation in Oral Keratinocytes

(2008) J. G. Lyons et al.   CANCER RESEARCH