Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer

The flavonoid hesperidin exerts anti-photoaging effect by downregulating matrix metalloproteinase (MMP)-9 expression via mitogen activated protein kinase (MAPK)-dependent signaling pathways

(2018) Hee Jeong Lee et al.   BMC Complementary and Alternative Medicine

Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway

(2018) Rongmu Xia et al.   LIFE SCIENCES

MYC inhibition increases PD-L1 expression induced by IFN-γ in hepatocellular carcinoma cells

(2018) Jiahuan Zou et al.   MOLECULAR IMMUNOLOGY

The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells

(2018) Yue Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hesperidin Induces ROS-Mediated Apoptosis along with Cell Cycle Arrest at G2/M Phase in Human Gall Bladder Carcinoma

(2018) Pratibha Pandey et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3–MMP2 signaling

(2018) Cong Bo et al.   OncoTargets and Therapy

Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells

(2017) Rongmu Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Activation of the PD-1/PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis

(2016) Madison Black et al.   Oncotarget

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

(2015) Yaoxian Wang et al.   BMC CANCER

Hesperidin Supplementation Modulates Inflammatory Responses Following Myocardial Infarction

(2015) F. Haidari et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

(2015) Abdullah Alsuliman et al.   Molecular Cancer

Hesperidin from Citrus seed induces human hepatocellular carcinoma HepG2 cell apoptosis via both mitochondrial and death receptor pathways

(2015) Ratana Banjerdpongchai et al.   TUMOR BIOLOGY

Development of PD-1/PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small Cell Lung Cancer

(2015) Jiabei He et al.   Scientific Reports

Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer

(2014) S. Muenst et al.   BREAST CANCER RESEARCH AND TREATMENT

HIF-1αhad Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes

(2014) Zhiqiang Chang et al.   TheScientificWorldJOURNAL

PD-L1 Expression in Triple-Negative Breast Cancer

(2014) E. A. Mittendorf et al.   Cancer Immunology Research

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

(2013) Omid Hamid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Hesperidin suppressed proliferations of both Human breast cancer and androgen-dependent prostate cancer cells

(2009) Choong Jae Lee et al.   PHYTOTHERAPY RESEARCH

In Vivo Pharmacokinetics of Hesperidin Are Affected by Treatment with Glucosidase-like BglA Protein Isolated from Yeasts

(2008) Yong-mei Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

(2008) C A Crane et al.   ONCOGENE