Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

(2016) Byoung-Cheol Lee et al.   BIOPHYSICAL JOURNAL

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Independent activation of distinct pores in dimeric TMEM16A channels

(2016) Grace Jeng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

(2016) Novandy K. Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cellular functions of TMEM16/anoctamin

(2016) Uhtaek Oh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

(2015) Sayuri Gyobu et al.   MOLECULAR AND CELLULAR BIOLOGY

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

Structure and insights into the function of a Ca2+-activated Cl− channel

(2014) Veronica Kane Dickson et al.   NATURE

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Beam-induced motion correction for sub-megadalton cryo-EM particles

(2014) Sjors HW Scheres   eLife

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

(2013) J. Tien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology

(2011) Eric R. Geertsma et al.   BIOCHEMISTRY

The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels

(2011) Paolo Scudieri et al.   EXPERIMENTAL PHYSIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

Characterization of the Oligomeric Structure of the Ca2+-activated Cl−Channel Ano1/TMEM16A

(2010) John T. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels

(2010) Ghada Fallah et al.   MOLECULAR & CELLULAR PROTEOMICS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Bestrophin and TMEM16—Ca2+ activated Cl− channels with different functions

(2009) Karl Kunzelmann et al.   CELL CALCIUM

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE