A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)

Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A

(2019) Maiwase Tembo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis

(2019) David Crottès et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual regulation of hEAG1 channels by phosphatidylinositol 4,5-bisphosphate

(2018) Mayra Delgado-Ramírez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)

(2018) José J. De Jesús-Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The TMEM16A channel mediates the fast polyspermy block inXenopus laevis

(2018) Katherine L. Wozniak et al.   JOURNAL OF GENERAL PHYSIOLOGY

The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach

(2018) Tae Sik Sung et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel

(2018) Christian J. Peters et al.   NEURON

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F

(2018) Wenlei Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

(2017) Johan-Owen De Craene et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extension of the Highly Mobile Membrane Mimetic to Transmembrane Systems through Customized in Silico Solvents

(2017) Josh V. Vermaas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lipid specificity of the membrane binding domain of coagulation factor X

(2017) M. P. Muller et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

(2017) Deepti Karandur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Soluble Fluorescent Binding Assay Reveals PIP 2 Antagonism of TREK-1 Channels

(2017) Cerrone Cabanos et al.   Cell Reports

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail

(2016) Josh V. Vermaas et al.   BIOCHEMISTRY

Atomic-level description of protein–lipid interactions using an accelerated membrane model

(2016) Javier L. Baylon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Anoctamin 6 Contributes to Cl−Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea

(2016) Joydeep Aoun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent activation of distinct pores in dimeric TMEM16A channels

(2016) Grace Jeng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

(2016) Novandy K. Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cellular functions of TMEM16/anoctamin

(2016) Uhtaek Oh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

(2015) Diomedes E. Logothetis et al.   Annual Review of Physiology

Lipid agonism: The PIP2 paradigm of ligand-gated ion channels

(2015) Scott B. Hansen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

CHARMM-GUI HMMM Builder for Membrane Simulations with the Highly Mobile Membrane-Mimetic Model

(2015) Yifei Qi et al.   BIOPHYSICAL JOURNAL

Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution

(2015) Josh V. Vermaas et al.   JOURNAL OF MEMBRANE BIOLOGY

Phosphoinositide regulation of TRPV1 revisited

(2015) Tibor Rohacs   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A fluid secretion pathway unmasked by acinar-specificTmem16Agene ablation in the adult mouse salivary gland

(2015) Marcelo A. Catalán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1

(2015) Xiaoying Jian et al.   STRUCTURE

Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery

(2014) H A T Pritchard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dipole Moment and Binding Energy of Water in Proteins from Crystallographic Analysis

(2014) A. Morozenko et al.   Journal of Chemical Theory and Computation

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

(2014) Kuai Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Partitioning of Amino Acids into a Model Membrane: Capturing the Interface

(2014) Taras V. Pogorelov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

(2014) Jason Tien et al.   eLife

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

(2014) Weiwei Wang et al.   eLife

Energetics and Location of Phosphoinositide Binding in Human Kir2.1 Channels

(2013) Nazzareno D'Avanzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels

(2013) Sun-Joo Lee et al.   Nature Communications

Accelerating Membrane Insertion of Peripheral Proteins with a Novel Membrane Mimetic Model

(2012) Y. Zenmei Ohkubo et al.   BIOPHYSICAL JOURNAL

Control of TMEM16A by INO-4995 and other inositolphosphates

(2012) Yuemin Tian et al.   BRITISH JOURNAL OF PHARMACOLOGY

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

(2012) U. Duvvuri et al.   CANCER RESEARCH

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Ca2+-activated Cl- channels at a glance

(2012) J. Berg et al.   JOURNAL OF CELL SCIENCE

Physiological roles and diseases of tmem16/anoctamin proteins: are they all chloride channels?

(2011) Charity Duran et al.   ACTA PHARMACOLOGICA SINICA

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graphical analysis of pH-dependent properties of proteins predicted using PROPKA

(2011) Michał Rostkowski et al.   BMC STRUCTURAL BIOLOGY

Tmem16AEncodes the Ca2+-activated Cl−Channel in Mouse Submandibular Salivary Gland Acinar Cells

(2010) Victor G. Romanenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An Experimentally Based Computer Search Identifies Unstructured Membrane-binding Sites in Proteins

(2009) Hanna Brzeska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SuperLooper--a prediction server for the modeling of loops in globular and membrane proteins

(2009) P. W. Hildebrand et al.   NUCLEIC ACIDS RESEARCH

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE