Structure of the mechanosensitive OSCA channels

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC

(2017) Peng Jin et al.   NATURE

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels

(2017) Jason Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

Independent activation of distinct pores in dimeric TMEM16A channels

(2016) Grace Jeng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

(2016) Novandy K. Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana

(2016) Alexander F. Kintzer et al.   NATURE

Highly efficient baculovirus-mediated multigene delivery in primary cells

(2016) Maysam Mansouri et al.   Nature Communications

Piezo1 Channels Are Inherently Mechanosensitive

(2016) Ruhma Syeda et al.   Cell Reports

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel

(2015) Wei Zhang et al.   CELL

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

(2015) Jiangtao Guo et al.   NATURE

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DUF221 proteins are a family of osmosensitive calcium-permeable cation channels conserved across eukaryotes

(2014) Congcong Hou et al.   CELL RESEARCH

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis

(2014) Fang Yuan et al.   NATURE

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Response of plants to water stress

(2014) Yuriko Osakabe et al.   Frontiers in Plant Science

Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models

(2013) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Distinct Roles of TRP Channels in Auditory Transduction and Amplification in Drosophila

(2013) Brendan P. Lehnert et al.   NEURON

Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae

(2013) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Low-resolution refinement tools inREFMAC5

(2012) Robert A. Nicholls et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The MscS and MscL Families of Mechanosensitive Channels Act as Microbial Emergency Release Valves

(2012) Ian R. Booth et al.   JOURNAL OF BACTERIOLOGY

An Extension and Further Validation of an All-Atomistic Force Field for Biological Membranes

(2012) Joakim P. M. Jämbeck et al.   Journal of Chemical Theory and Computation

Derivation and Systematic Validation of a Refined All-Atom Force Field for Phosphatidylcholine Lipids

(2012) Joakim P. M. Jämbeck et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation

(2012) Zhiqiang Yan et al.   NATURE

Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL

(2012) Julia F. Doerner et al.   Nature Communications

Mechanosensitive Channels: What Can They Do and How Do They Do It?

(2011) Elizabeth S. Haswell et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE