Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

An inner activation gate controls TMEM16F phospholipid scrambling

(2019) Trieu Le et al.   Nature Communications

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F

(2019) Carolina Alvadia et al.   eLife

Phosphatidylinositol 4,5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl- channel TMEM16A

(2019) Maiwase Tembo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

(2019) Shengjie Feng et al.   Cell Reports

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)

(2019) Kuai Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A

(2019) Son C. Le et al.   Nature Communications

Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate

(2019) Jorge Arreola et al.   CELL CALCIUM

Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1)

(2018) José J. De Jesús-Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Known structures and unknown mechanisms of TMEM16 scramblases and channels

(2018) Maria E. Falzone et al.   JOURNAL OF GENERAL PHYSIOLOGY

Recent advances in TMEM16A: Structure, function, and disease

(2018) Qiushuang Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM

(2017) Cristina Paulino et al.   NATURE

Cryo-EM structures of the TMEM16A calcium-activated chloride channel

(2017) Shangyu Dang et al.   NATURE

Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A

(2017) Cristina Paulino et al.   eLife

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

(2017) Tao Jiang et al.   eLife

Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain

(2017) Mohammad M. Sultan et al.   Scientific Reports

Optimized parameter selection reveals trends in Markov state models for protein folding

(2016) Brooke E. Husic et al.   JOURNAL OF CHEMICAL PHYSICS

Independent activation of distinct pores in dimeric TMEM16A channels

(2016) Grace Jeng et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent activation of ion conduction pores in the double-barreled calcium-activated chloride channel TMEM16A

(2016) Novandy K. Lim et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular Basis for Differential Anion Binding and Proton Coupling in the Cl–/H+ Exchanger ClC-ec1

(2016) Tao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variational cross-validation of slow dynamical modes in molecular kinetics

(2015) Robert T. McGibbon et al.   JOURNAL OF CHEMICAL PHYSICS

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

TMEM16 Proteins: Unknown Structure and Confusing Functions

(2015) Alessandra Picollo et al.   JOURNAL OF MOLECULAR BIOLOGY

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Ano1 (TMEM16A) chloride channel by calcium is not mediated by calmodulin

(2014) Kuai Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Preferred Orientations of Phosphoinositides in Bilayers and Their Implications in Protein Recognition Mechanisms

(2014) Emilia L. Wu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Improvements in Markov State Model Construction Reveal Many Non-Native Interactions in the Folding of NTL9

(2013) Christian R. Schwantes et al.   Journal of Chemical Theory and Computation

Anion permeation in calcium-activated chloride channels formed by TMEM16A from Xenopus tropicalis

(2013) J. P. Reyes et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NetworkView: 3D display and analysis of protein{middle dot}RNA interaction networks

(2012) J. Eargle et al.   BIOINFORMATICS

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MSMBuilder2: Modeling Conformational Dynamics on the Picosecond to Millisecond Scale

(2011) Kyle A. Beauchamp et al.   Journal of Chemical Theory and Computation

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tmem16AEncodes the Ca2+-activated Cl−Channel in Mouse Submandibular Salivary Gland Acinar Cells

(2010) Victor G. Romanenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

The TMEM16 Protein Family: A New Class of Chloride Channels?

(2009) Luis J.V. Galietta   BIOPHYSICAL JOURNAL

Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl–Secretory Channel in Mouse Airways

(2009) Jason R. Rock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarizable Force Field Development and Molecular Dynamics Simulations of Ionic Liquids

(2009) Oleg Borodin   JOURNAL OF PHYSICAL CHEMISTRY B

A Ca2+-activated Cl−conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

(2009) Mei Hong Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology

(2008) Thomas J. Jentsch   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Well-Tempered Metadynamics: A Smoothly Converging and Tunable Free-Energy Method

(2008) Alessandro Barducci et al.   PHYSICAL REVIEW LETTERS

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE