Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion

Untangling the complexity of limb-girdle muscular dystrophies

(2018) Teerin Liewluck et al.   MUSCLE & NERVE

An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase

(2018) Thomas Pelz et al.   PLoS One

Development of muscular dystrophy in a CRISPR-engineered mutant rabbit model with frame-disrupting ANO5 mutations

(2018) Tingting Sui et al.   Cell Death & Disease

Extracellular Vesicles Released by Oxidatively Injured or Intact C2C12 Myotubes Promote Distinct Responses Converging toward Myogenesis

(2017) Michele Guescini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

(2017) Tao Jiang et al.   eLife

The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel

(2016) Byoung-Cheol Lee et al.   BIOPHYSICAL JOURNAL

Novel function of stabilin-2 in myoblast fusion: the recognition of extracellular phosphatidylserine as a "fuse-me" signal

(2016) Go-Woon Kim et al.   BMB Reports

Structural basis for phospholipid scrambling in the TMEM16 family

(2016) Janine D Brunner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Defective membrane fusion and repair inAnoctamin5-deficient muscular dystrophy

(2016) Danielle A. Griffin et al.   HUMAN MOLECULAR GENETICS

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

(2016) Jarred M. Whitlock et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

(2016) Edouard M. Bevers et al.   PHYSIOLOGICAL REVIEWS

Atomistic insight into lipid translocation by a TMEM16 scramblase

(2016) Neville P. Bethel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo

(2016) D. B. Gurevich et al.   SCIENCE

Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration

(2016) Seung-Yoon Park et al.   Nature Communications

Mechanisms of myoblast fusion during muscle development

(2015) Ji Hoon Kim et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

TMEM16 Proteins: Unknown Structure and Confusing Functions

(2015) Alessandra Picollo et al.   JOURNAL OF MOLECULAR BIOLOGY

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility

(2015) Sayuri Gyobu et al.   MOLECULAR AND CELLULAR BIOLOGY

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

(2015) Toshihiro Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a lipid scrambling domain in ANO6/TMEM16F

(2015) Kuai Yu et al.   eLife

Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy

(2015) Jing Xu et al.   Skeletal Muscle

Glycobiology of  -dystroglycan and muscular dystrophy

(2014) T. Endo   JOURNAL OF BIOCHEMISTRY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Membrane Injury and Repair in the Muscular Dystrophies

(2014) Sandra T. Cooper et al.   NEUROSCIENTIST

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Caveolae internalization repairs wounded cells and muscle fibers

(2013) Matthias Corrotte et al.   eLife

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm

(2012) S-H Lee et al.   CELL DEATH AND DIFFERENTIATION

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

Myoblast fusion: lessons from flies and mice

(2012) S. M. Abmayr et al.   DEVELOPMENT

ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

(2011) Charity Duran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes

(2011) Jaemin Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recessive Mutations in the Putative Calcium-Activated Chloride Channel Anoctamin 5 Cause Proximal LGMD2L and Distal MMD3 Muscular Dystrophies

(2010) Véronique Bolduc et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A founder mutation in Anoctamin 5 is a major cause of limb girdle muscular dystrophy

(2010) D. Hicks et al.   BRAIN

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

A new distal myopathy with mutation in anoctamin 5

(2010) Ibrahim Mahjneh et al.   NEUROMUSCULAR DISORDERS

Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis

(2009) Banafsheh Mirnikjoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE