A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid

TRP channels interaction with lipids and its implications in disease

(2015) Francisco J. Taberner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function

(2015) John E. Baenziger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid agonism: The PIP2 paradigm of ligand-gated ion channels

(2015) Scott B. Hansen   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Study of NGEP expression pattern in cancerous tissues provides novel insights into prognostic marker in prostate cancer

(2015) Monireh Mohsenzadegan et al.   Biomarkers in Medicine

9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels

(2015) Sarah K Burris et al.   BRITISH JOURNAL OF PHARMACOLOGY

TMEM16 Proteins: Unknown Structure and Confusing Functions

(2015) Alessandra Picollo et al.   JOURNAL OF MOLECULAR BIOLOGY

Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

(2015) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations

(2015) Marco Savarese et al.   NEUROMUSCULAR DISORDERS

The EMBL-EBI bioinformatics web and programmatic tools framework

(2015) Weizhong Li et al.   NUCLEIC ACIDS RESEARCH

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels

(2015) Christian J. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance

(2015) Sandra V. Verstraeten et al.   Food & Function

Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

(2015) Zao Li et al.   PLoS Genetics

The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes

(2014) Daniel Koller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Protein Arcs May Form Stable Pores in Lipid Membranes

(2014) Lidia Prieto et al.   BIOPHYSICAL JOURNAL

Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes

(2014) S S Metkar et al.   CELL DEATH AND DIFFERENTIATION

Pharmacological characterization of TMEM16A currents

(2014) Eamonn Bradley et al.   Channels

Roles and regulation of phospholipid scramblases

(2014) Karthik M. Kodigepalli et al.   FEBS LETTERS

Exposure of Phosphatidylserine by Xk-related Protein Family Members during Apoptosis

(2014) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel

(2014) Giulia Betto et al.   JOURNAL OF GENERAL PHYSIOLOGY

ANO10 mutations cause ataxia and coenzyme Q10 deficiency

(2014) Andrea Balreira et al.   JOURNAL OF NEUROLOGY

Red Wine Tannins Fluidify and Precipitate Lipid Liposomes and Bicelles. A Role for Lipids in Wine Tasting?

(2014) Aurélien L. Furlan et al.   LANGMUIR

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Common variants associated with general and MMR vaccine–related febrile seizures

(2014) Bjarke Feenstra et al.   NATURE GENETICS

Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels

(2014) Yani Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca2+

(2014) C. A. Juul et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Structure and Function of TMEM16 Proteins (Anoctamins)

(2014) Nicoletta Pedemonte et al.   PHYSIOLOGICAL REVIEWS

Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels

(2014) Yu-Li Ni et al.   PLoS One

Feeling the hidden mechanical forces in lipid bilayer is an original sense

(2014) A. Anishkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane pore formation at protein–lipid interfaces

(2014) Robert J.C. Gilbert et al.   TRENDS IN BIOCHEMICAL SCIENCES

Incomplete pneumolysin oligomers form membrane pores

(2014) A. F.- P. Sonnen et al.   Open Biology

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity

(2014) Jason Tien et al.   eLife

Cholesterol binding to ion channels

(2014) Irena Levitan et al.   Frontiers in Physiology

Lipid Ion Channels and the Role of Proteins

(2013) Lars D. Mosgaard et al.   ACCOUNTS OF CHEMICAL RESEARCH

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lipid modulation of ion channels through specific binding sites

(2013) J.A. Poveda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ER–PM connections: sites of information transfer and inter-organelle communication

(2013) Christopher J Stefan et al.   CURRENT OPINION IN CELL BIOLOGY

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes

(2013) Aiste Adomaviciene et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing

(2013) Fen Huang et al.   NATURE NEUROSCIENCE

Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?

(2013) Karl Kunzelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01

(2012) Alison J Davis et al.   BRITISH JOURNAL OF PHARMACOLOGY

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Expression and Functional Significance of the Ca2+-Activated Cl-Channel ANO6 in Dendritic Cells

(2012) Kalina Szteyn et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Yeast Ist2 Recruits the Endoplasmic Reticulum to the Plasma Membrane and Creates a Ribosome-Free Membrane Microcompartment

(2012) Wendelin Wolf et al.   PLoS One

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

(2011) Charity Duran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes

(2011) Jaemin Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Regulation of protein kinases by lipids

(2011) Thomas A Leonard et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

(2011) T. LHERMUSIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

(2011) Sunil S. Metkar et al.   PLoS One

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Transbilayer Lipid Asymmetry

(2011) G. van Meer   Cold Spring Harbor Perspectives in Biology

Recessive Mutations in the Putative Calcium-Activated Chloride Channel Anoctamin 5 Cause Proximal LGMD2L and Distal MMD3 Muscular Dystrophies

(2010) Véronique Bolduc et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings

(2010) Y.V. Bobkov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid ion channels

(2010) T. Heimburg   BIOPHYSICAL CHEMISTRY

A founder mutation in Anoctamin 5 is a major cause of limb girdle muscular dystrophy

(2010) D. Hicks et al.   BRAIN

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Human Perforin Employs Different Avenues to Damage Membranes

(2010) Tilen Praper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells

(2010) Claudia Sagheddu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

CFTR: Break a pump, make a channel

(2010) C. Miller   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A

(2009) Joana Almaça et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Molecular mediators of macrophage fusion

(2009) Laura Helming et al.   TRENDS IN CELL BIOLOGY

Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function

(2008) R. Urrea Moreno et al.   BLOOD

Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level

(2008) S. Das et al.   CANCER RESEARCH

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

The MACPF/CDC family of pore-forming toxins

(2008) Carlos J. Rosado et al.   CELLULAR MICROBIOLOGY

Anoctamin/TMEM16 family members are Ca2+-activated Cl−channels

(2008) H. Criss Hartzell et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ClC-0 chloride channel is a 'broken' Cl−/H+ antiporter

(2008) Jiří Lísal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters

(2008) I. King Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE