Structure and Function of TMEM16 Proteins (Anoctamins)

TMEM16F is a component of a Ca2+-activated Cl− channel but not a volume-sensitive outwardly rectifying Cl− channel

(2013) Takahiro Shimizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans

(2013) Ying Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

TMEM16A–TMEM16B chimaeras to investigate the structure–function relationship of calcium-activated chloride channels

(2013) Paolo Scudieri et al.   BIOCHEMICAL JOURNAL

Non-canonical translation start sites in the TMEM16A chloride channel

(2013) Elvira Sondo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis

(2013) Manon Ruffin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation

(2013) R. van Kruchten et al.   BLOOD

DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors

(2013) S. Simon et al.   CANCER RESEARCH

Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members

(2013) Jun Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels

(2013) Kerstin Vocke et al.   JOURNAL OF GENERAL PHYSIOLOGY

Channel properties of the splicing isoforms of the olfactory calcium-activated chloride channel Anoctamin 2

(2013) Samsudeen Ponissery Saidu et al.   JOURNAL OF GENERAL PHYSIOLOGY

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+activation

(2013) Søren Grubb et al.   JOURNAL OF GENERAL PHYSIOLOGY

Divalent Cations Modulate TMEM16A Calcium-Activated Chloride Channels by a Common Mechanism

(2013) Hongbo Yuan et al.   JOURNAL OF MEMBRANE BIOLOGY

Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes

(2013) Aiste Adomaviciene et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst–forming epithelial cells

(2013) Bjoern Buchholz et al.   KIDNEY INTERNATIONAL

TMEM16A alternative splicing coordination in breast cancer

(2013) Ifeoma Ubby et al.   Molecular Cancer

A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors

(2013) Corrie J B daCosta et al.   Nature Chemical Biology

TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing

(2013) Fen Huang et al.   NATURE NEUROSCIENCE

Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)

(2013) J. Tien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

(2013) Adrian Britschgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Cl- Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

(2013) X. Jin et al.   Science Signaling

Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents

(2013) A Kmit et al.   Cell Death & Disease

Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel

(2013) Mattia Malvezzi et al.   Nature Communications

Subdued, a TMEM16 family Ca2+-activated Cl− channel in Drosophila melanogaster with an unexpected role in host defense

(2013) Xiu Ming Wong et al.   eLife

Mutations in ANO3 Cause Dominant Craniocervical Dystonia: Ion Channel Implicated in Pathogenesis

(2012) Gavin Charlesworth et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension

(2012) Abigail S. Forrest et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanosensitive Cl− secretion in biliary epithelium mediated through TMEM16A

(2012) Amal K. Dutta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Transmembrane Protein 16A Ca2+-activated Cl−Channel in Airway Smooth Muscle Contributes to Airway Hyperresponsiveness

(2012) Cheng-Hai Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inhibition of cell proliferation by a selective inhibitor of the Ca2+-activated Cl− channel, Ano1

(2012) Amelia Mazzone et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of TMEM16A by INO-4995 and other inositolphosphates

(2012) Yuemin Tian et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01

(2012) Alison J Davis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Ca2+-activated Cl− channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma

(2012) Wen Liu et al.   CANCER LETTERS

TMEM16A Induces MAPK and Contributes Directly to Tumorigenesis and Cancer Progression

(2012) U. Duvvuri et al.   CANCER RESEARCH

TMEM16F Forms a Ca2+-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation

(2012) Huanghe Yang et al.   CELL

Expression and Functional Significance of the Ca2+-Activated Cl-Channel ANO6 in Dendritic Cells

(2012) Kalina Szteyn et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Downregulation of TMEM16A Calcium-Activated Chloride Channel Contributes to Cerebrovascular Remodeling During Hypertension by Promoting Basilar Smooth Muscle Cell Proliferation

(2012) Mi Wang et al.   CIRCULATION

Explaining Calcium-Dependent Gating of Anoctamin-1 Chloride Channels Requires a Revised Topology

(2012) Kuai Yu et al.   CIRCULATION RESEARCH

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

A novel missense mutation in ANO5/TMEM16E is causative for gnathodiaphyseal dyplasia in a large Italian pedigree

(2012) Caterina Marconi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues

(2012) Harald WA Ehlen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Anoctamins are a family of Ca2+-activated Cl- channels

(2012) Y. Tian et al.   JOURNAL OF CELL SCIENCE

Epidermal growth factor chronically upregulates Ca2+-dependent Cl−conductance and TMEM16A expression in intestinal epithelial cells

(2012) Magdalena S. Mroz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction

(2012) Gerardo Orta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chronic hypoxia-induced upregulation of Ca2+-activated Cl−channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity

(2012) Hui Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia

(2012) Paolo Scudieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

(2012) Guido Veit et al.   MOLECULAR BIOLOGY OF THE CELL

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

(2012) Hawon Cho et al.   NATURE NEUROSCIENCE

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

(2012) Wendy C. Huang et al.   NEURON

Novel antithrombotic agents for atrial fibrillation

(2012) Maria M. Niespialowska-Steuden et al.   PHARMACOLOGY & THERAPEUTICS

Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca2+-Activated Cl− Channel TMEM16A

(2012) Zhen Yao et al.   PLoS One

Yeast Ist2 Recruits the Endoplasmic Reticulum to the Plasma Membrane and Creates a Ribosome-Free Membrane Microcompartment

(2012) Wendelin Wolf et al.   PLoS One

Enhanced Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration and Correlates with Poor Prognosis

(2012) Christian Ruiz et al.   PLoS One

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network

(2012) P. Perez-Cornejo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

(2012) C. Ehre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

(2012) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ANOs 3–7 in the anoctamin/Tmem16 Cl− channel family are intracellular proteins

(2011) Charity Duran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ano1 as a regulator of proliferation

(2011) Jennifer E. Stanich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A minimal isoform of the TMEM16A protein associated with chloride channel activity

(2011) Loretta Ferrera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Electrical Slow Waves in the Mouse Oviduct Are Dependent upon a Calcium Activated Chloride Conductance Encoded by Tmem16a1

(2011) Rose Ellen Dixon et al.   BIOLOGY OF REPRODUCTION

Compound heterozygosity for 2 novel TMEM16F mutations in a patient with Scott syndrome

(2011) E. Castoldi et al.   BLOOD

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing

(2011) Kate E O'Driscoll et al.   BMC MOLECULAR BIOLOGY

CFTR and TMEM16A are Separate but Functionally Related Cl- Channels

(2011) Jiraporn Ousingsawat et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Expression and function of epithelial anoctamins

(2011) Karl Kunzelmann et al.   EXPERIMENTAL PHYSIOLOGY

Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction

(2011) Wan Namkung et al.   FASEB JOURNAL

Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis

(2011) Amelia Mazzone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells

(2011) James P. Garnett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Niflumic acid blocks native and recombinant T-type channels

(2011) Enrique Balderas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

(2011) T. LHERMUSIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ca2+-activated Cl− currents are dispensable for olfaction

(2011) Gwendolyn M Billig et al.   NATURE NEUROSCIENCE

Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation

(2011) P. Kashyap et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption

(2011) Jiraporn Ousingsawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel

(2011) J. R. Martins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

(2011) Q. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive exposure of phosphatidylserine on viable cells

(2011) K. Segawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons

(2011) SangSeong Kim et al.   Nature Communications

Targeted Next-Generation Sequencing of a 12.5 Mb Homozygous Region Reveals ANO10 Mutations in Patients with Autosomal-Recessive Cerebellar Ataxia

(2010) Sascha Vermeer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Recessive Mutations in the Putative Calcium-Activated Chloride Channel Anoctamin 5 Cause Proximal LGMD2L and Distal MMD3 Muscular Dystrophies

(2010) Véronique Bolduc et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Expression profile and protein translation of TMEM16A in murine smooth muscle

(2010) Alison J. Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype

(2010) Horst Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Evolution and functional divergence of the anoctamin family of membrane proteins

(2010) Vladimir M Milenkovic et al.   BMC EVOLUTIONARY BIOLOGY

A founder mutation in Anoctamin 5 is a major cause of limb girdle muscular dystrophy

(2010) D. Hicks et al.   BRAIN

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines

(2010) C Ayoub et al.   BRITISH JOURNAL OF CANCER

Exon-Based Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative Exons Whose Expression Is Associated with Metastasis

(2010) M. Dutertre et al.   CANCER RESEARCH

Cholesterol depletion alters amplitude and pharmacology of vascular calcium-activated chloride channels

(2010) William R. Sones et al.   CARDIOVASCULAR RESEARCH

Tmem16b is Specifically Expressed in the Cilia of Olfactory Sensory Neurons

(2010) Sebastian Rasche et al.   CHEMICAL SENSES

Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy

(2010) Hon Yee Lai et al.   Current Opinion in Allergy and Clinical Immunology

Activation of the basolateral membrane Cl−conductance essential for electrogenic K+secretion suppresses electrogenic Cl−secretion

(2010) Quanhua He et al.   EXPERIMENTAL PHYSIOLOGY

Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea

(2010) Wan Namkung et al.   FASEB JOURNAL

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

(2010) Yuemin Tian et al.   FASEB JOURNAL

Phospholipid scramblase: An update

(2010) Edouard M. Bevers et al.   FEBS LETTERS

Characterization of the Oligomeric Structure of the Ca2+-activated Cl−Channel Ano1/TMEM16A

(2010) John T. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Function of Epithelial Anoctamins

(2010) Rainer Schreiber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tmem16AEncodes the Ca2+-activated Cl−Channel in Mouse Submandibular Salivary Gland Acinar Cells

(2010) Victor G. Romanenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells

(2010) Wan Namkung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Characterization of TMEM16A, a Ca2+-activated Cl−Channel Activated by Extracellular Nucleotides, in Biliary Epithelium

(2010) Amal K. Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels

(2010) Boyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Location of Release Sites and Calcium-Activated Chloride Channels Relative to Calcium Channels at the Photoreceptor Ribbon Synapse

(2010) A. J. Mercer et al.   JOURNAL OF NEUROPHYSIOLOGY

Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells

(2010) Claudia Sagheddu et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A/Anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells

(2010) Boris Manoury et al.   JOURNAL OF PHYSIOLOGY-LONDON

TMEM16A(a)/anoctamin-1 Shares a Homodimeric Architecture with CLC Chloride Channels

(2010) Ghada Fallah et al.   MOLECULAR & CELLULAR PROTEOMICS

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Vascular smooth muscle phenotypic diversity and function

(2010) Steven A. Fisher   PHYSIOLOGICAL GENOMICS

Anion-Sensitive Regions of L-Type CaV1.2 Calcium Channels Expressed in HEK293 Cells

(2010) Norbert Babai et al.   PLoS One

Spatial Distribution of Calcium-Gated Chloride Channels in Olfactory Cilia

(2010) Donald A. French et al.   PLoS One

Molecular components of signal amplification in olfactory sensory cilia

(2010) T. Hengl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of the human membrane proteome

(2010) Linn Fagerberg et al.   PROTEOMICS

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract

(2009) Pedro J. Gomez-Pinilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Novel Monoclonal Antibody Against DOG1 is a Sensitive and Specific Marker for Gastrointestinal Stromal Tumors

(2009) Inigo Espinosa et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Chloride Channels: Often Enigmatic, Rarely Predictable

(2009) Charity Duran et al.   Annual Review of Physiology

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin

(2009) Markus Almén et al.   BMC BIOLOGY

Phosphorylation alters the pharmacology of Ca2+-activated Cl- channels in rabbit pulmonary arterial smooth muscle cells

(2009) M Wiwchar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Bestrophin and TMEM16—Ca2+ activated Cl− channels with different functions

(2009) Karl Kunzelmann et al.   CELL CALCIUM

Complex Phosphatase Regulation of Ca2+-activated Cl−Currents in Pulmonary Arterial Smooth Muscle Cells

(2009) Ramon Ayon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16 Proteins Produce Volume-regulated Chloride Currents That Are Reduced in Mice Lacking TMEM16A

(2009) Joana Almaça et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TMEM16A Chloride Channel Properties by Alternative Splicing

(2009) Loretta Ferrera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl–Secretory Channel in Mouse Airways

(2009) Jason R. Rock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

(2009) Jiraporn Ousingsawat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation

(2009) Tony Yeung et al.   JOURNAL OF CELL BIOLOGY

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator–dependent bicarbonate secretion

(2009) Mary Abigail S. Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium-activated chloride current amplifies the response to urine in mouse vomeronasal sensory neurons

(2009) Chun Yang et al.   JOURNAL OF GENERAL PHYSIOLOGY

TMEM16B, A Novel Protein with Calcium-Dependent Chloride Channel Activity, Associates with a Presynaptic Protein Complex in Photoreceptor Terminals

(2009) H. Stohr et al.   JOURNAL OF NEUROSCIENCE

A Ca2+-activated Cl−conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

(2009) Mei Hong Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

(2009) Sung Jin Hwang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Chloride channels as drug targets

(2009) Alan S. Verkman et al.   NATURE REVIEWS DRUG DISCOVERY

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel

(2009) René Barro-Soria et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TMEM16B induces chloride currents activated by calcium in mammalian cells

(2009) Simone Pifferi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

(2009) Aaron B. Stephan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Studies on expression and function of the TMEM16A calcium-activated chloride channel

(2009) Fen Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

Evidence for direct CFTR inhibition by CFTRinh-172 based on Arg347mutagenesis

(2008) Emanuela Caci et al.   BIOCHEMICAL JOURNAL

Topology of NGEP, a Prostate-Specific Cell:Cell Junction Protein Widely Expressed in Many Cancers of Different Grade Level

(2008) S. Das et al.   CANCER RESEARCH

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

The transmembrane protein TMEM16A is required for normal development of the murine trachea

(2008) Jason R. Rock et al.   DEVELOPMENTAL BIOLOGY

A Carboxy-terminal Inter-Helix Linker As the Site of Phosphatidylinositol 4,5-Bisphosphate Action on Kv7 (M-type) K+Channels

(2008) Ciria C. Hernandez et al.   JOURNAL OF GENERAL PHYSIOLOGY

Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice

(2008) Elise Bonvin et al.   JOURNAL OF PHYSIOLOGY-LONDON

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Galectin-1 Induces Reversible Phosphatidylserine Exposure at the Plasma Membrane

(2008) Sean R. Stowell et al.   MOLECULAR BIOLOGY OF THE CELL

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE