Role of lysosomes in physiological activities, diseases, and therapy

Artemisinin attenuated atherosclerosis in high-fat diet-fed ApoE-/- mice by promoting macrophage autophagy via AMPK/mTOR/ULK1 pathway

(2020) Qian Cao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway

(2020) Ana Sanches-Silva et al.   PHARMACOLOGICAL RESEARCH

Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice

(2020) Sharmilla Devi Jayasingam et al.   Frontiers in Oncology

Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases

(2020) Frédéric Darios et al.   JOURNAL OF MOLECULAR BIOLOGY

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

(2020) Purvi C. Trivedi et al.   Cells

Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer

(2020) Song Park et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review

(2020) Franz Geisslinger et al.   Frontiers in Oncology

Genetics and pathophysiology of pancreatitis

(2019) Julia Mayerle et al.   GASTROENTEROLOGY

Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis

(2019) Kuang-Chung Chiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition

(2019) Junfeng Wu et al.   OncoTargets and Therapy

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

(2019) Eva Vidak et al.   Cells

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

(2019) Yahya Ashraf et al.   Journal for ImmunoTherapy of Cancer

T cell stemness and dysfunction in tumors are triggered by a common mechanism

(2019) Suman Kumar Vodnala et al.   SCIENCE

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

(2019) Daisuke Muraoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Defective Sphingolipids Metabolism and Tumor Associated Macrophages as the Possible Links Between Gaucher Disease and Blood Cancer Development

(2019) Marzena Wątek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The prognostic significance of lysosomal protective protein (Cathepsin A) in breast ductal carcinoma in situ

(2019) Michael S Toss et al.   HISTOPATHOLOGY

miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway

(2019) Xincheng Liu et al.   CANCER LETTERS

A novel derivative of artemisinin inhibits cell proliferation and metastasis via down-regulation of cathepsin K in breast cancer

(2019) Xiangyu Gu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy

(2019) Qiang Cai et al.   Molecular Cancer

Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma

(2019) Junya Nishimura et al.   Esophagus

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

Interaction of tumor-associated macrophages and cancer chemotherapy

(2019) Irina Larionova et al.   OncoImmunology

From Subclinical Atherosclerosis to Plaque Progression and Acute Coronary Events

(2019) Amir Ahmadi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

Cathepsin L secretion by host and neoplastic cells potentiates invasion

(2019) Samantha S. Dykes et al.   Oncotarget

Cysteine Cathepsins in Tumor-Associated Immune Cells

(2019) Tanja Jakoš et al.   Frontiers in Immunology

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Selectively targeting tumor-associated macrophages and tumor cells with polymeric micelles for enhanced cancer chemo-immunotherapy

(2019) Xiao Wei et al.   JOURNAL OF CONTROLLED RELEASE

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

(2019) Xianbin Zhang et al.   Journal of Advanced Research

Autophagy in T Cell Function and Aging

(2019) Fernando Macian   Frontiers in Cell and Developmental Biology

Macrophages in Atherosclerosis Regression

(2019) Tessa J. Barrett   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trichostatin A modulates the macrophage phenotype by enhancing autophagy to reduce inflammation during polymicrobial sepsis

(2019) Shu-Nan Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gaucheromas: When macrophages promote tumor formation and dissemination

(2018) Margarita Ivanova et al.   BLOOD CELLS MOLECULES AND DISEASES

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

(2018) Frank K. Leusink et al.   BMC CANCER

Selective autophagy restricts IL-9 secretion from TH9 cells: relevance in cancer growth

(2018) Isis Benoit-Lizon et al.   CELL CYCLE

Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells

(2018) Tejinder Pal Khaket et al.   CELLULAR SIGNALLING

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine AtherosclerosisNovelty and Significance

(2018) Clément Cochain et al.   CIRCULATION RESEARCH

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

(2018) Matthias Sendler et al.   GASTROENTEROLOGY

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

(2018) Lina Al-Akra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1

(2018) Zhi-wei Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma

(2018) Yuhua Wang et al.   MOLECULAR THERAPY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Defective Autophagy in Atherosclerosis: To Die or to Senesce?

(2018) Mandy O. J. Grootaert et al.   Oxidative Medicine and Cellular Longevity

miR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA

(2018) Shujuan Ni et al.   OncoTargets and Therapy

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

(2018) Cynthia L. Hsu et al.   Nature Communications

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma

(2018) María Inés Molejon et al.   Oncotarget

Spermine Alleviates Acute Liver Injury by Inhibiting Liver-Resident Macrophage Pro-Inflammatory Response Through ATG5-Dependent Autophagy

(2018) Shun Zhou et al.   Frontiers in Immunology

The Immune and Non-Immune Pathways That Drive Chronic Gastrointestinal Helminth Burdens in the Wild

(2018) Simon A. Babayan et al.   Frontiers in Immunology

Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target

(2018) Maliha Khan et al.   Frontiers in Immunology

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells

(2018) Yudong Song et al.   BIOMATERIALS

LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

(2018) Larissa D. Cunha et al.   CELL

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

(2018) Xiaoyan Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding early TLR signaling through the Myddosome

(2018) Katherine R. Balka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lysosome biogenesis in health and disease

(2018) Lakshya Bajaj et al.   JOURNAL OF NEUROCHEMISTRY

Pompe Disease: From Basic Science to Therapy

(2018) Lara Kohler et al.   Neurotherapeutics

Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs

(2018) Jorge Vallecillo-Hernández et al.   Scientific Reports

Multiwalled Carbon Nanotubes Prevent Tumor Metastasis Through Switching M2-Polarized Macrophages to M1 via TLR4 Activation

(2018) Lianlian Wu et al.   Journal of Biomedical Nanotechnology

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression

(2018) Na Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

(2018) Benny Zhitomirsky et al.   Cell Death & Disease

Inflammation and cancer

(2018) Mariko Murata   Environmental Health and Preventive Medicine

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment

(2018) Chunmei Fu et al.   Frontiers in Immunology

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

(2018) Xianbin Zhang et al.   Frontiers in Oncology

Cationic polysaccharide spermine-pullulan drives tumor associated macrophage towards M1 phenotype to inhibit tumor progression

(2018) Lifei Xie et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells

(2017) Ana Mitrović et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

(2017) Anna S. Gukovskaya et al.   GASTROENTEROLOGY

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone

(2017) Kumsal Tekirdag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells

(2017) Xi-Long Zhao et al.   JOURNAL OF PATHOLOGY

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

(2017) Cheng-Chang Chen et al.   Nature Protocols

Emptying the stores: lysosomal diseases and therapeutic strategies

(2017) Frances M. Platt   NATURE REVIEWS DRUG DISCOVERY

Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+dendritic cells

(2017) Vrajesh V. Parekh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

(2017) Walaa Eid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

LAMPs: Shedding light on cancer biology

(2017) Federica Alessandrini et al.   SEMINARS IN ONCOLOGY

Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders

(2017) Nicoletta Plotegher et al.   TRENDS IN MOLECULAR MEDICINE

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells

(2017) Thaiz Rivera Vargas et al.   Nature Communications

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells

(2017) Zhaohu Lin et al.   Oncotarget

Expression of Cathepsin K in Skull Base Chordoma

(2017) Kaibing Tian et al.   World Neurosurgery

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

(2017) Daniel Hargbøl Madsen et al.   Cell Reports

Cancer-Associated Fibroblasts Autophagy Enhances Progression of Triple-Negative Breast Cancer Cells

(2017) Mengchuan Wang et al.   MEDICAL SCIENCE MONITOR

Translational Significance for Tumor Metastasis of Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition

(2017) Wenzhe Song et al.   Frontiers in Immunology

Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non–Small Cell Lung Cancer

(2017) Nicholas Willumsen et al.   NEOPLASIA

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection

(2016) Zhen Huang et al.   BIOMATERIALS

Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells

(2016) Yao Fei et al.   BRAIN RESEARCH

Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy

(2016) Ilias V Karagounis et al.   BRITISH JOURNAL OF CANCER

Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro

(2016) Wenjuan Wang et al.   CANCER LETTERS

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

(2016) William Herrington et al.   CIRCULATION RESEARCH

Atherosclerosis and aortic aneurysm - is inflammation a common denominator?

(2016) Iuliia O. Peshkova et al.   FEBS Journal

Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis

(2016) Rupjyoti Talukdar et al.   GASTROENTEROLOGY

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

(2016) Amra Saric et al.   MOLECULAR BIOLOGY OF THE CELL

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Radiation-induced autophagy promotes esophageal squamous cell carcinoma cell survival via the LKB1 pathway

(2016) CHI LU et al.   ONCOLOGY REPORTS

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

(2016) Andrew J. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Derivatives of 6-cinnamamido-quinoline-4-carboxamide impair lysosome function and induce apoptosis

(2016) Hsiao-Hui Kuo et al.   Oncotarget

Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer

(2016) Hongying Sui et al.   Oncotarget

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8 + T Cell Responses

(2016) Monica Loi et al.   Cell Reports

Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-κB signaling pathway

(2015) Neng Yang et al.   ACTA PHARMACOLOGICA SINICA

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

(2015) Qing-qing Zhang et al.   ACTA PHARMACOLOGICA SINICA

Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

(2015) Elma Aflaki et al.   AGING CELL

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

TMEM175 Is an Organelle K + Channel Regulating Lysosomal Function

(2015) Chunlei Cang et al.   CELL

Macrophage polarization in pathology

(2015) Antonio Sica et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impaired Autophagy Induces Chronic Atrophic Pancreatitis in Mice via Sex- and Nutrition-Dependent Processes

(2015) Kalliope N. Diakopoulos et al.   GASTROENTEROLOGY

Response to Feng Tian et al.: mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis

(2015) Yuan-yuan Guo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Huntingtin functions as a scaffold for selective macroautophagy

(2015) Yan-Ning Rui et al.   NATURE CELL BIOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

(2015) Richard D.A. Wilkinson et al.   Oncotarget

Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies

(2015) Timo Gemoll et al.   Oncotarget

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response

(2015) Xiaojun Xia et al.   Cell Reports

The Many Alternative Faces of Macrophage Activation

(2015) David A. Hume   Frontiers in Immunology

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

(2015) Benny Zhitomirsky et al.   Oncotarget

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mucolipidosis type IV: The importance of functional lysosomes for efficient autophagy

(2014) Silvia Vergarajauregui et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Cancer Immunotherapy and Breaking Immune Tolerance: New Approaches to an Old Challenge

(2014) A. Makkouk et al.   CANCER RESEARCH

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis

(2014) Ding Ai et al.   CIRCULATION RESEARCH

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells

(2014) Francesca Bellora et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The current stage of cathepsin B inhibitors as potential anticancer agents

(2014) Janko Kos et al.   Future Medicinal Chemistry

Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

(2014) Leila Akkari et al.   GENES & DEVELOPMENT

mTOR mediates the cross-talk of macrophage polarization and autophagy in atherosclerosis

(2014) Feng Tian et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Autophagic Cell Death and Cancer

(2014) Shigeomi Shimizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fabry's disease

(2014) Rima El-Abassi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages

(2014) Johnathan Canton et al.   MOLECULAR BIOLOGY OF THE CELL

Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

(2014) Min Yang et al.   Molecular Cancer

A Novel Photodynamic Therapy Targeting Cancer Cells and Tumor-Associated Macrophages

(2014) N. Hayashi et al.   MOLECULAR CANCER THERAPEUTICS

Lysosomal cholesterol accumulation: driver on the road to inflammation during atherosclerosis and non-alcoholic steatohepatitis

(2014) T. Hendrikx et al.   Obesity Reviews

Characterization of cathepsin X in colorectal cancer development and progression

(2014) Doerthe Jechorek et al.   PATHOLOGY RESEARCH AND PRACTICE

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

(2014) A. R. Mantegazza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

uPAR and cathepsin B-mediated compartmentalization of JNK regulates the migration of glioma-initiating cells

(2014) Kiranmai Alapati et al.   Stem Cell Research

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

(2014) Angelika Bilger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Plasma cathepsin L: A prognostic marker for pancreatic cancer

(2014) Nidhi Singh   WORLD JOURNAL OF GASTROENTEROLOGY

Autophagy supports genomic stability by degrading retrotransposon RNA

(2014) Huishan Guo et al.   Nature Communications

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

(2013) Chih-Peng Chang et al.   Autophagy

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages

(2013) Jiao Peng et al.   CANCER LETTERS

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

(2013) Paola Avena et al.   CELL CYCLE

ATM pathway is essential for ionizing radiation-induced autophagy

(2013) Nan Liang et al.   CELLULAR SIGNALLING

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

(2013) B. Ruffell et al.   GENES & DEVELOPMENT

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

(2013) Taiji Tsunemi et al.   HUMAN MOLECULAR GENETICS

Sorafenib induces autophagy and suppresses activation of human macrophage

(2013) Jiunn-Chang Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Intercellular adhesion molecule-1 (ICAM-1) expression correlates with oral cancer progression and induces macrophage/cancer cell adhesion

(2013) Yu Usami et al.   INTERNATIONAL JOURNAL OF CANCER

Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy

(2013) AN-CHENG HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Cholesteryl ester storage disease: a rare and possibly treatable cause of premature vascular disease and cirrhosis

(2013) Tim Reynolds   JOURNAL OF CLINICAL PATHOLOGY

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

(2013) Zhen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Structure Watch

(2013) Alison Schuldt   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cathepsin E Is a Marker of Gastric Differentiation and Signet-Ring Cell Carcinoma of Stomach: A Novel Suggestion on Gastric Tumorigenesis

(2013) Maki Konno-Shimizu et al.   PLoS One

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer

(2012) Niels Fristrup et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy and pancreatitis

(2012) Anna S. Gukovskaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The potential prognostic value of cathepsin D protein in serous ovarian cancer

(2012) Yun Chai et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers

(2012) Zhen Huang et al.   BIOMATERIALS

Expression of Cysteine Protease Cathepsin L is Increased in Endometrial Cancer and Correlates With Expression of Growth Regulatory Genes

(2012) Maciej Skrzypczak et al.   CANCER INVESTIGATION

Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression

(2012) Sreelatha Gopinath et al.   CARCINOGENESIS

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production

(2012) Ahmed F. Salem et al.   CELL CYCLE

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin

(2012) Kamaldeen A. Muili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells

(2012) R. R. Malla et al.   NEURO-ONCOLOGY

Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study

(2012) Chuifeng Fan et al.   TUMOR BIOLOGY

AGR2 Is a Novel Surface Antigen That Promotes the Dissemination of Pancreatic Cancer Cells through Regulation of Cathepsins B and D

(2011) L. Dumartin et al.   CANCER RESEARCH

Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1

(2011) Ling Chen et al.   CARCINOGENESIS

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models

(2011) Zobeida Cruz-Monserrate et al.   GUT

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease

(2011) H. Koga et al.   JOURNAL OF NEUROSCIENCE

Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression

(2011) Rui Wang et al.   LUNG CANCER

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Overview of the mucopolysaccharidoses

(2011) J. Muenzer   RHEUMATOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer

(2010) Vasilena Gocheva et al.   BIOLOGICAL CHEMISTRY

Targeting MMP-9, uPAR and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells

(2010) A K Nalla et al.   CANCER GENE THERAPY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

TAU Aggregation is a Therapeutic Target for Alzheimers Disease

(2010) A. Takashima   Current Alzheimer Research

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

(2010) Yuri Frosi et al.   JOURNAL OF CELL BIOLOGY

The Clinical and Genetic Features of Huntington Disease

(2010) Aaron Sturrock et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage

(2010) P. K. Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The values and limits of an in vitro model of Pompe disease: The best laid schemes o’ mice an’ men ……..†

(2009) Shoichi Takikita et al.   Autophagy

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma

(2009) Zhuomin Wang et al.   BIOMARKERS

Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor

(2009) L Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

(2009) Haiyan You et al.   CANCER LETTERS

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes

(2009) Jibin Zeng et al.   EXPERIMENTAL CELL RESEARCH

Cystatins and cancer

(2009) James et al.   Frontiers in Bioscience-Landmark

Cathepsin L Inactivates Human Trypsinogen, Whereas Cathepsin L-Deletion Reduces the Severity of Pancreatitis in Mice

(2009) Thomas Wartmann et al.   GASTROENTEROLOGY

Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer

(2009) Shane Sullivan et al.   INTERNATIONAL JOURNAL OF CANCER

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma

(2009) David F. Schaeffer et al.   JOURNAL OF LIPID RESEARCH

Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis

(2009) M. Schuur et al.   NEUROBIOLOGY OF AGING

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Sortilin mediates the lysosomal targeting of cathepsins D and H

(2008) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cathepsins: Key modulators of cell death and inflammatory responses

(2008) Sébastien Conus et al.   BIOCHEMICAL PHARMACOLOGY

Identification of Novel Nasopharyngeal Carcinoma Biomarkers by Laser Capture Microdissection and Proteomic Analysis

(2008) A.-L. Cheng et al.   CLINICAL CANCER RESEARCH

Radiation-induced cathepsin S is involved in radioresistance

(2008) Haeng Ran Seo et al.   INTERNATIONAL JOURNAL OF CANCER

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

(2008) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival

(2008) Colja Cordes et al.   LUNG CANCER

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR−/− mice despite severe hypercholesterolemia

(2007) Marc A. Mueller et al.   ATHEROSCLEROSIS