Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin

Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice

(2012) Sohail Z. Husain et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

(2012) Kamaldeen A. Muili et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice

(2012) Darbaz Awla et al.   GASTROENTEROLOGY

Impaired autophagy and organellar dysfunction in pancreatitis

(2012) Ilya Gukovsky et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Localized Calcineurin Confers Ca2+-Dependent Inactivation on Neuronal L-Type Ca2+ Channels

(2012) S. F. Oliveria et al.   JOURNAL OF NEUROSCIENCE

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

(2011) David M. Booth et al.   GASTROENTEROLOGY

Ethanol Enhances Carbachol-induced Protease Activation and Accelerates Ca2+Waves in Isolated Rat Pancreatic Acini

(2011) Abrahim I. Orabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis

(2011) Aree Abdulla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

What Have We Learned About Acute Pancreatitis in Children?

(2011) Harrison X Bai et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Risk Factors Associated With Biliary Pancreatitis in Children

(2011) Michael H. Ma et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors

(2011) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells

(2010) Svetlana G. Voronina et al.   GASTROENTEROLOGY

Regulator of Calcineurin 1 Controls Growth Plasticity of Adult Pancreas

(2010) Grzegorz T. Gurda et al.   GASTROENTEROLOGY

Non-conjugated chenodeoxycholate induces severe mitochondrial damage and inhibits bicarbonate transport in pancreatic duct cells

(2010) J. Maleth et al.   GUT

The acinar-ductal tango in the pathogenesis of acute pancreatitis

(2010) P. Hegyi et al.   GUT

Opposing Action of Casein Kinase 1 and Calcineurin in Nucleo-cytoplasmic Shuttling of Mammalian Translation Initiation Factor eIF6

(2010) Arunima Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental acute biliary pancreatitis induced by retrograde infusion of bile acids into the mouse pancreatic duct

(2010) George Perides et al.   Nature Protocols

Etiology and diagnosis of acute biliary pancreatitis

(2010) Erwin J. M. van Geenen et al.   Nature Reviews Gastroenterology & Hepatology

Interaction of calcineurin with substrates and targeting proteins

(2010) Huiming Li et al.   TRENDS IN CELL BIOLOGY

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein−Coupled Cell Surface Bile Acid Receptor Gpbar1

(2009) George Perides et al.   GASTROENTEROLOGY

Intracellular Trypsin Induces Pancreatic Acinar Cell Death but Not NF-κB Activation

(2009) Baoan Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig

(2008) V Venglovecz et al.   GUT

Acute pancreatitis

(2008) Jean-Louis Frossard et al.   LANCET

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarized Calcium Signaling in Exocrine Gland Cells

(2007) Ole H. Petersen et al.   Annual Review of Physiology

Cholecystokinin Activates Pancreatic Calcineurin-NFAT Signaling In Vitro and In Vivo

(2007) Grzegorz T. Gurda et al.   MOLECULAR BIOLOGY OF THE CELL