Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs

Mitigated NSAID-induced apoptotic and autophagic cell death with Smad7 overexpression

(2017) Ho-Jae Lee et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy

(2016) David A. Gewirtz   CANCER RESEARCH

Stress management by autophagy: Implications for chemoresistance

(2016) Zhao Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Lysosomes relax in the cellular suburbs

(2016) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages

(2016) Chan Young Ock et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Impact and mechanism of non-steroidal anti-inflammatory drugs combined with chemotherapeutic drugs on human lung cancer-nude mouse transplanted tumors

(2016) WEIYI SUN et al.   Oncology Letters

Aspirin as a neoadjuvant agent during preoperative chemoradiation for rectal cancer

(2015) Angelo Restivo et al.   BRITISH JOURNAL OF CANCER

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy

(2015) Carlos Hernández et al.   JOURNAL OF GASTROENTEROLOGY

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Cellular and metabolic functions for autophagy in cancer cells

(2015) Candia M. Kenific et al.   TRENDS IN CELL BIOLOGY

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer

(2014) CHRISTINA LÖNNROTH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cost-Effectiveness of Aspirin Adjuvant Therapy in Early Stage Colorectal Cancer in Older Patients

(2014) Swee Sung Soon et al.   PLoS One

BID mediates selective killing of APC-deficient cells in intestinal tumor suppression by nonsteroidal antiinflammatory drugs

(2014) Brian Leibowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome: the cell's ‘suicidal bag’ as a promising cancer target

(2014) Melina-Theoni Gyparaki et al.   TRENDS IN MOLECULAR MEDICINE

Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: Current state-of-the science

(2013) Ibrahim Halil Sahin et al.   CANCER LETTERS

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Suppression of Lysosome Function Induces Autophagy via a Feedback Down-regulation of MTOR Complex 1 (MTORC1) Activity

(2013) Min Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indomethacin Sensitizes TRAIL-Resistant Melanoma Cells to TRAIL-Induced Apoptosis through ROS-Mediated Upregulation of Death Receptor 5 and Downregulation of Survivin

(2013) Anfernee Kai-Wing Tse et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sulindac sulfide induces autophagic death in gastric epithelial cells via Survivin down-regulation: A mechanism of NSAIDs-induced gastric injury

(2011) Shiun-Kwei Chiou et al.   BIOCHEMICAL PHARMACOLOGY

Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells

(2010) Shengbing Huang et al.   Autophagy

Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1, 25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling

(2010) Farnaz Jamshidi et al.   CELL CYCLE

Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells

(2009) William Ka Kei Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhancement of Doxorubicin Cytotoxicity on Human Esophageal Squamous Cell Carcinoma Cells by Indomethacin and 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC236) via Inhibiting P-Glycoprotein Activity

(2009) L. Yu et al.   MOLECULAR PHARMACOLOGY