Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy

(2017) Lei Shi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

(2016) Danuta S. Kalinowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc(II)–Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity

(2016) Alexandra E. Stacy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance

(2016) Alexandra E. Stacy et al.   JOURNAL OF MEDICINAL CHEMISTRY

The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells

(2016) GUANGLEI YANG et al.   Molecular Medicine Reports

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

(2016) Nicole A Seebacher et al.   Cell Death & Disease

Glucose modulation induces reactive oxygen species and increases P-glycoprotein-mediated multidrug resistance to chemotherapeutics

(2015) N A Seebacher et al.   BRITISH JOURNAL OF PHARMACOLOGY

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)

(2015) Patric J. Jansson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

(2015) Nicole A. Seebacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Microenvironment and Endoplasmic Reticulum Stress Response

(2015) Claudia Giampietri et al.   MEDIATORS OF INFLAMMATION

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones

(2015) Patric J. Jansson et al.   PHARMACOLOGICAL RESEARCH

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells

(2014) ARATA NISHIMOTO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

(2014) Jürgen Brojatsch et al.   PLoS One

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

(2012) Chan Yeom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo

(2012) David B. Lovejoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

(2011) Naseem Akhtar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance

(2011) Jason R. Hickok et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Thiosemicarbazone Iron Chelators Induce Up-Regulation and Phosphorylation of the Metastasis Suppressor N-myc Down-Stream Regulated Gene 1: A New Strategy for the Treatment of Pancreatic Cancer

(2011) Z. Kovacevic et al.   MOLECULAR PHARMACOLOGY

The tumor microenvironment

(2011) Cynthia E. Weber et al.   SURGICAL ONCOLOGY-OXFORD

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Clioquinol targets zinc to lysosomes in human cancer cells

(2008) Haijun Yu et al.   BIOCHEMICAL JOURNAL

Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line

(2008) L. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Zinc and 4-Hydroxy-2-Nonenal Mediate Lysosomal Membrane Permeabilization Induced by H2O2 in Cultured Hippocampal Neurons

(2008) J. J. Hwang et al.   JOURNAL OF NEUROSCIENCE

Lysosomal membrane permeabilization in cell death

(2008) P Boya et al.   ONCOGENE

ABC multidrug transporters: structure, function and role in chemoresistance

(2007) Frances J Sharom   PHARMACOGENOMICS