Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

Executive Summary: Heart Disease and Stroke Statistics—2014 Update

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Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis

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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

(2012) Xianghai Liao et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Disruption of the Autophagy-Lysosome Pathway Is Involved in Neuropathology of the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis

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Regulation of Lipid Droplet Cholesterol Efflux From Macrophage Foam Cells

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Selective autophagy mediated by autophagic adapter proteins

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Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Modified Low Density Lipoproteins Decrease the Activity and Expression of Lysosomal Acid Lipase in Human Endothelial and Smooth Muscle Cells

(2011) Constantina Heltianu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

(2011) Philipp S. Wild et al.   Circulation-Cardiovascular Genetics

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

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Progress and challenges in translating the biology of atherosclerosis

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A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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TFEB Links Autophagy to Lysosomal Biogenesis

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A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A Gene Network Regulating Lysosomal Biogenesis and Function

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Autophagy in the Pathogenesis of Disease

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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