Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism

(2013) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment

(2013) Ahmed F. Salem et al.   CELL CYCLE

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

(2012) Barbara Chiavarina et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

(2012) Karen N. Wu et al.   CELL CYCLE

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial metabolism in cancer metastasis

(2012) Federica Sotgia et al.   CELL CYCLE

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production

(2012) Ahmed F. Salem et al.   CELL CYCLE

Metabolic reprogramming and two-compartment tumor metabolism

(2012) Barbara Chiavarina et al.   CELL CYCLE

Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth

(2012) Valentina Carito et al.   CELL CYCLE

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

Ketone body utilization drives tumor growth and metastasis

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

(2012) Ahmed F. Salem et al.   CELL CYCLE

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

(2012) Claudia Capparelli et al.   CELL CYCLE

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Mitochondrial dysfunction in breast cancer cells prevents tumor growth

(2012) Rosa Sanchez-Alvarez et al.   CELL CYCLE

Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

(2012) Ubaldo E. Martinez-Outschoorn et al.   Cell Metabolism

Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells

(2012) Daniela Rovito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

(2012) Samantha A Simpkins et al.   JOURNAL OF PATHOLOGY

Mitochondrial Biogenesis Drives Tumor Cell Proliferation

(2011) Ubaldo E. Martinez-Outschoorn et al.   AMERICAN JOURNAL OF PATHOLOGY

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Artepillin C, as a PPARγ ligand, enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells

(2011) Sun-Sil Choi et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients

(2011) Niansong Qian et al.   CANCER SCIENCE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Understanding the metabolic basis of drug resistance

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells

(2011) Lidia Cerquetti et al.   EXPERIMENTAL CELL RESEARCH

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Stromal Caveolin-1 Expression in Breast Carcinoma. Correlation with Early Tumor Recurrence and Clinical Outcome

(2011) Saba Mohamed El-Gendi et al.   PATHOLOGY & ONCOLOGY RESEARCH

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

(2011) Ja Seung Koo et al.   TUMOR BIOLOGY

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Peroxisome proliferator-activated receptor-γ in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

(2010) Stamatios Theocharis et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

PPARγ activation induces autophagy in breast cancer cells

(2009) Jie Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PPARγ and Wnt/β-Catenin pathway in human breast cancer: expression pattern, molecular interaction and clinical/prognostic correlations

(2009) Ying Jiang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Peroxisome proliferator-activated receptors γ and α agonists stimulate cardiac glucose uptake via activation of AMP-activated protein kinase☆

(2009) Xiaoyan Xiao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Peroxisome proliferator-activated receptor gamma expression in urothelial carcinomas of the bladder: Association with differentiation, proliferation and clinical outcome

(2008) E. Mylona et al.   EJSO