Targeting Lysosomes in Cancer as Promising Strategy to Overcome Chemoresistance—A Mini Review

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition

(2019) Junfeng Wu et al.   OncoTargets and Therapy

HRAS‐driven cancer cells are vulnerable to TRPML1 inhibition

(2019) Jewon Jung et al.   EMBO REPORTS

The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways

(2019) Mengnan Xu et al.   CELL CALCIUM

Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy

(2019) Qiang Cai et al.   Molecular Cancer

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

(2019) Logan Slade et al.   BIOCHEMICAL JOURNAL

TRPing the homeostatic alarm — Melanoma cells are selectively vulnerable to TRPML1 deletion

(2019) Jewon Jung et al.   CELL CALCIUM

MicroRNA-1 overexpression increases chemosensitivity of non-small cell lung cancer cells by inhibiting autophagy related 3-mediated autophagy

(2018) Li Hua et al.   CELL BIOLOGY INTERNATIONAL

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

(2018) Lina Al-Akra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

(2018) Bradleigh Whitton et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

(2018) Andreas Noack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity

(2018) Benny Zhitomirsky et al.   Cell Death & Disease

Endolysosomal Ca2+ Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!

(2018) Pawan Faris et al.   Cancers

Therapeutic Potential and Utility of Elacridar with Respect to P-glycoprotein Inhibition: An Insight from the Published In Vitro, Preclinical and Clinical Studies

(2017) Ranjeet Prasad Dash et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis

(2017) Benny Zhitomirsky et al.   Oncotarget

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

(2017) Irene Pafumi et al.   Scientific Reports

Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells

(2016) Baoqing Guo et al.   BMC CANCER

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

Current Challenges in Cancer Treatment

(2016) Jon Zugazagoitia et al.   CLINICAL THERAPEUTICS

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

(2016) Nicole A Seebacher et al.   Cell Death & Disease

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy

(2016) Karin Bartel et al.   Oncotarget

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer

(2015) L. S. Schneider et al.   CANCER RESEARCH

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

MicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy

(2015) RUIDA XU et al.   ONCOLOGY REPORTS

miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2

(2015) Y An et al.   Cell Death & Disease

Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

(2015) Benny Zhitomirsky et al.   Oncotarget

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling

(2014) A. Favia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

V-ATPase inhibition overcomes trastuzumab resistance in breast cancer

(2013) Karin von Schwarzenberg et al.   Molecular Oncology

Lysosomal Membrane Proteins and Their Central Role in Physiology

(2013) Michael Schwake et al.   TRAFFIC

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis

(2012) Grace A. Colletti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes

(2011) D. B. Lovejoy et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Intracellular trafficking of P-glycoprotein

(2011) Dong Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells

(2010) Clotilde Ferrándiz-Huertas et al.   INTERNATIONAL JOURNAL OF CANCER

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells

(2009) Haiyan You et al.   CANCER LETTERS

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal involvement in cell death and cancer

(2008) Thomas Kirkegaard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6

(2008) Sophia Semerdjieva et al.   JOURNAL OF CELL BIOLOGY

Membrane identity and GTPase cascades regulated by toggle and cut-out switches

(2008) Perla Del Conte-Zerial et al.   Molecular Systems Biology