mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

PKD1 is downregulated in non-small cell lung cancer and mediates the feedback inhibition of mTORC1-S6K1 axis in response to phorbol ester

(2015) Yang Ni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

(2014) Natalia Schiefermeier et al.   JOURNAL OF CELL BIOLOGY

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

(2014) Norihiro Nakamura et al.   NATURE

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

(2014) A. R. Mantegazza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR regulates phagosome and entotic vacuole fission

(2013) Matej Krajcovic et al.   MOLECULAR BIOLOGY OF THE CELL

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of a Sensitive Phospho-p70 S6 Kinase ELISA to Quantify mTOR Proliferation Signal Inhibition

(2013) Bertram Hartmann et al.   THERAPEUTIC DRUG MONITORING

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

TLR4-Mediated AKT Activation Is MyD88/TRIF Dependent and Critical for Induction of Oxidative Phosphorylation and Mitochondrial Transcription Factor A in Murine Macrophages

(2012) C. P. Bauerfeld et al.   JOURNAL OF IMMUNOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages

(2012) Amra Mrakovic et al.   TRAFFIC

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology

(2011) L. Swiech et al.   JOURNAL OF NEUROSCIENCE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

(2010) Serhiy Pankiv et al.   JOURNAL OF CELL BIOLOGY

Role of the mTOR Pathway in LPS-Activated Monocytes: Influence of Hypertonic Saline

(2010) Valérie Schaeffer et al.   JOURNAL OF SURGICAL RESEARCH

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells

(2008) M. Ohtani et al.   BLOOD

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL