Defective Sphingolipids Metabolism and Tumor Associated Macrophages as the Possible Links Between Gaucher Disease and Blood Cancer Development

A rare form of Gaucher disease resulting from saposin C deficiency

(2018) Lulu Kang et al.   BLOOD CELLS MOLECULES AND DISEASES

Gaucheromas: When macrophages promote tumor formation and dissemination

(2018) Margarita Ivanova et al.   BLOOD CELLS MOLECULES AND DISEASES

Nanoliposome C6-Ceramide Increases the Anti-tumor Immune Response and Slows Growth of Liver Tumors in Mice

(2018) Guangfu Li et al.   GASTROENTEROLOGY

Serum chitotriosidase: a circulating biomarker in polycythemia vera

(2018) Ivan Krecak et al.   Hematology

Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease

(2018) Gyula Batta et al.   Scientific Reports

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

(2018) Ewelina Piktel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease

(2017) Tomasz Wollny et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments

(2017) Jérôme Stirnemann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia

(2017) Marzena Wątek et al.   Lipids in Health and Disease

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma

(2016) Shiny Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chitotriosidase: A New Inflammatory Marker in Diabetic Complications

(2016) Michelino Di Rosa et al.   PATHOBIOLOGY

Utility of blood procalcitonin concentration in the management of cancer patients with infections

(2016) Katarzyna Niemirowicz et al.   OncoTargets and Therapy

Glycosphingolipids and cell death: one aim, many ways

(2015) Carmen Garcia-Ruiz et al.   APOPTOSIS

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease

(2015) Adel Ersek et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Chitotriosidase in the Pathogenesis of Inflammation, Interstitial Lung Diseases and COPD

(2015) Soo Jung Cho et al.   Allergy Asthma & Immunology Research

Enhanced proteotoxic stress: one of the contributors for hyperthermic potentiation of the proteasome inhibitor bortezomib using magnetic nanoparticles

(2015) Merlis P. Alvarez-Berrios et al.   Biomaterials Science

The basic structure and dynamics of cell membranes: An update of the Singer–Nicolson model

(2014) Félix M. Goñi   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Chitinase 3 like 1 is associated with tumor angiogenesis in cervical cancer

(2014) Nipaporn Ngernyuang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy

(2014) Elena V Pavlova et al.   JOURNAL OF PATHOLOGY

Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis

(2014) Xiao-Wei Wang et al.   TUMOR BIOLOGY

Role of Endosomes and Lysosomes in Human Disease

(2014) F. R. Maxfield   Cold Spring Harbor Perspectives in Biology

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Lipid composition of membrane rafts, isolated with and without detergent, from the spleen of a mouse model of Gaucher disease

(2013) Kathryn J. Hattersley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B cell lymphoma and myeloma in murine Gaucher's disease

(2013) EV Pavlova et al.   JOURNAL OF PATHOLOGY

Glucosylceramide modulates endolysosomal pH in Gaucher disease

(2013) Dan J. Sillence   MOLECULAR GENETICS AND METABOLISM

Targeting Sphingosine-1-Phosphate Receptors in Cancer

(2012) Rebecca J. Watters et al.   Anti-Cancer Agents in Medicinal Chemistry

S1PR1 is an effective target to block STAT3 signaling in activated B cell-like diffuse large B-cell lymphoma

(2012) Y. Liu et al.   BLOOD

First Evidence of Sphingosine 1-Phosphate Lyase Protein Expression and Activity Downregulation in Human Neoplasm: Implication for Resistance to Therapeutics in Prostate Cancer

(2012) L. Brizuela et al.   MOLECULAR CANCER THERAPEUTICS

The role of saposin C in Gaucher disease

(2012) Rafael J. Tamargo et al.   MOLECULAR GENETICS AND METABOLISM

Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response

(2011) N. Dekker et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Exploring the link between glucocerebrosidase mutations and parkinsonism

(2011) Wendy Westbroek et al.   TRENDS IN MOLECULAR MEDICINE

Plasma gelsolin modulates cellular response to sphingosine 1-phosphate

(2010) Robert Bucki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tumor-associated macrophages infiltrate plasmacytomas and can serve as cell carriers for oncolytic measles virotherapy of disseminated myeloma

(2009) Kah-Whye Peng et al.   AMERICAN JOURNAL OF HEMATOLOGY

Glucocerebroside: an evolutionary advantage for patients with Gaucher disease and a new immunomodulatory agent

(2009) Yaron Ilan et al.   IMMUNOLOGY AND CELL BIOLOGY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use

(2008) Robert Bucki et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Lipid composition of microdomains is altered in a cell model of Gaucher disease

(2008) Leanne K. Hein et al.   JOURNAL OF LIPID RESEARCH

Glucosylceramide accumulation is not confined to the lysosome in fibroblasts from patients with Gaucher disease

(2008) Maria Fuller et al.   MOLECULAR GENETICS AND METABOLISM

Plasma glucosylceramide and ceramide in type 1 Gaucher disease patients: Correlations with disease severity and response to therapeutic intervention

(2007) J GROENER   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS