Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

(2017) Katharina Essig et al.   IMMUNITY

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

(2017) Lifan Xu et al.   IMMUNITY

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

A Sweet Solution: Glycolysis-Dependent Treg Cell Migration

(2017) Ronen Alon   IMMUNITY

Architecture of the human interactome defines protein communities and disease networks

(2017) Edward L. Huttlin et al.   NATURE

Ionic immune suppression within the tumour microenvironment limits T cell effector function

(2016) Robert Eil et al.   NATURE

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

(2016) Kristen N Pollizzi et al.   NATURE IMMUNOLOGY

Phosphatase PP2A is requisite for the function of regulatory T cells

(2016) Sokratis A Apostolidis et al.   NATURE IMMUNOLOGY

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi

(2015) Qiang Zou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

(2014) Christian A. Bauer et al.   JOURNAL OF CLINICAL INVESTIGATION

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

(2014) Qiang Zou et al.   NATURE IMMUNOLOGY

Metabolic Regulation of Regulatory T Cell Development and Function

(2014) David John Coe et al.   Frontiers in Immunology

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)

(2012) Anna R. Malik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

(2012) Jae-Hoon Chang et al.   NATURE IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Control of mTORC1 signaling by the Opitz syndrome protein MID1

(2011) E. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology