Review
Nutrition & Dietetics
Maitane Gonzalez-Arceo, Saioa Gomez-Zorita, Leixuri Aguirre, Maria P. Portillo
Summary: An overview of scientific evidence on the beneficial effects of microalgae and macroalgae extracts on non-alcoholic fatty liver disease (NAFLD) shows improvement in the condition. Further research is needed to understand the mechanisms of action and confirm the effects observed in rodents in human studies.
Review
Nutrition & Dietetics
Qiongbo Wu, Zihao Chen, Yi Ding, Yunting Tang, Yawei Cheng
Summary: This article summarizes the mechanism and application of Traditional Chinese Medicine in the regulation of non-alcoholic fatty liver disease through the ferroptosis pathway.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Zhijia Zhou, Jinghao Zhang, Liping You, Tao Wang, Kaixia Wang, Lingtai Wang, Xiaoni Kong, Yueqiu Gao, Xuehua Sun
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global health problem, and traditional Chinese medicine (TCM) has shown potential in its treatment. This article summarizes the research and evidence on the effectiveness of herbal therapy for NAFLD or NASH, and attempts to establish the links between TCM theory and modern pharmacological mechanisms. It provides ideas and perspectives for further exploration of the pathogenesis of NAFLD and herbal therapy, promoting the scientific connotation of TCM theories and the modernization of TCM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mingmei Shao, Yifei Lu, Hongjiao Xiang, Junmin Wang, Guang Ji, Tao Wu
Summary: NAFLD, a common chronic liver disease, often coexists with insulin resistance-related diseases, posing serious health threats. Developing more efficient diagnostic methods for early detection of NAFLD is crucial. Traditional Chinese medicine can improve symptoms and protect target organs, while metabolomics provides valuable biomarkers for NAFLD diagnosis and potential mechanisms of Chinese medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Honglin Zhou, Cheng Ma, Cheng Wang, Lihong Gong, Yafang Zhang, Yunxia Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common chronic liver diseases in the world due to the improvement of living standards and changes in eating habits. Traditional Chinese medicines (TCM) have attracted attention for their multi-target and multi-channel mechanisms in treating NAFLD, showing potential through regulating various pathways for ameliorating the disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Ke Zhu, Yongsong Guo, Chenghao Zhao, Shixin Kang, Jialiang Li, Jiexin Wang, Zhaohui Tang, Bing Lin, Weihong Li
Summary: The phlegm-dampness constitution is independently associated with NAFLD, suggesting it may be a risk factor. Further longitudinal studies are needed to confirm this relationship. Other biased TCM constitutions were not significantly associated with NAFLD.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Yi Chen, Xueyang Chen, Qiang Chen, Chaohui Yu
Summary: The prevalence of NAFLD is higher in PA patients compared to non-PA patients, with hypokalemic PA patients having a worse metabolic status. Although NAFLD is more common in PA patients, the patterns of obesity, dyslipidemia, and insulin resistance are similar. This study provides new insights for further investigations into metabolic imbalance in patients with aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Aldo Grefhorst, Ivo P. van de Peppel, Lars E. Larsen, Johan W. Jonker, Adriaan G. Holleboom
Summary: NAFLD is one of the most common liver disorders worldwide, with a complex etiology involving genetic susceptibility and unhealthy lifestyle factors. Disruption of hepatic lipid homeostasis, including the emerging role of lipophagy, is a key feature in the development and progression of NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Boya Zhang, Ying Zhou, Junyu Guo
Summary: Due to the wide use of volatile methylsiloxanes (VMSs) in various industries and consumer products, both cyclic VMSs (cVMS) and linear VMSs (lVMS) have been detected in human plasma. Positive associations of plasma cVMSs concentrations with liver enzymes and Nonalcoholic fatty liver disease (NAFLD) were observed among all participants. Furthermore, positive associations of total lVMSs with liver enzymes and NAFLD were also detected when analyzing participants living in industrial areas.
ENVIRONMENTAL POLLUTION
(2023)
Editorial Material
Gastroenterology & Hepatology
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Summary: The review highlights the crucial role of gut microbes in maintaining liver homeostasis and the impact of dysbiosis on the development of fatty liver disease. The changes in gut microbial composition in alcoholic and nonalcoholic fatty liver diseases and how they contribute to the pathophysiology of the disease are discussed. New approaches related to gut microbes for the diagnosis and treatment of fatty liver disease are also summarized.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Ying Yang, Yue Wu, Jie Zou, Yu-Hao Wang, Meng-Xia Xu, Wei Huang, Dao-Jiang Yu, Li Zhang, Yuan-Yuan Zhang, Xiao-Dong Sun
Summary: Naringenin (NAR) alleviates non-alcoholic fatty liver disease (NAFLD) by increasing energy expenditure and regulating autophagy through direct and indirect activation of AMPK signaling pathway. The direct binding of NAR and AMPK gamma 1 requires further validation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fei Zhou, Mingning Ding, Yiqing Gu, Guifang Fan, Chuanyang Liu, Yijie Li, Rong Sun, Jianzhi Wu, Jianchao Li, Xiaoyong Xue, Hongjuan Li, Xiaojiaoyang Li
Summary: Aurantio-obtusin (AO) has been shown to alleviate hepatic steatosis in mice and lipid accumulation in hepatocytes by promoting autophagy flux and activating AMPK/TFEB signaling pathway. This study provides new opportunities for the pharmacological treatment of nonalcoholic fatty liver disease (NAFLD) and associated complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chien-Chih Chen, Li-Wen Hsu, Kuang-Den Chen, King-Wah Chiu, Chao-Long Chen, Kuang-Tzu Huang
Summary: The liver plays a central role in energy metabolism and dysregulated Ca2+ signaling is closely associated with non-alcoholic fatty liver disease (NAFLD). Therefore, targeting Ca2+ signaling for treatment of NAFLD is of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Dongqing Wu, Huaqing Zhu, Hua Wang
Summary: The liver, as the largest vital solid organ in the body, consists of multiple types of cells that communicate critically to maintain liver function homeostasis. Extracellular vesicles (EVs) play a significant role in cell-to-cell communication and are involved in the development of liver diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Yuan Ma, Kewei Sun, Jianzhong Cao, Xiaowu Qin, Jiaoling Shi, Huiying Li, Jun Zhang, Tao Zhang
Summary: The study aims to evaluate the effectiveness and safety of acupuncture combined with Chinese herbal medicine for NAFLD, providing more evidence to determine whether this intervention is effective and safe.