Functions of autophagy in normal and diseased liver

Studying autophagy’s relationship to cell death

(2014) Andrew Thorburn   Autophagy

To be or not to be, the level of autophagy is the question: Dual roles of autophagy in the survival response to starvation

(2014) Chanhee Kang et al.   Autophagy

A critical role of superoxide anion in selenite-induced mitophagic cell death

(2014) Eun Hee Kim et al.   Autophagy

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells

(2014) Hua Zhu et al.   Autophagy

Mitochondrial permeability transition in rat hepatocytes after anoxia/reoxygenation: role of Ca2+-dependent mitochondrial formation of reactive oxygen species

(2012) Jae-Sung Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Critical role of autophagy in ischemia/reperfusion injury to aged livers

(2012) Jin-Hee Wang et al.   Autophagy

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

(2012) Jianhua Ling et al.   CANCER CELL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Regulation of Parkin E3 ubiquitin ligase activity

(2012) Helen Walden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

(2012) Ying Chang et al.   GASTROENTEROLOGY

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

(2012) Luis Fontana et al.   HEPATOLOGY

The Autophagy-related Gene 14 (Atg14) Is Regulated by Forkhead Box O Transcription Factors and Circadian Rhythms and Plays a Critical Role in Hepatic Autophagy and Lipid Metabolism

(2012) Xiwen Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Activation of the PI3K-AKT Pathway by Hepatitis C Virus to Enhance Viral Entry

(2012) Zhe Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin and Mitofusins Reciprocally Regulate Mitophagy and Mitochondrial Spheroid Formation

(2012) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron Microscopic Analysis of a Spherical Mitochondrial Structure

(2012) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

(2012) Donna Sir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: An Emerging Immunological Paradigm

(2012) V. Deretic   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Activates the mTOR/S6K1 Signaling Pathway in Inhibiting IRS-1 Function for Insulin Resistance

(2012) S. K. Bose et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity

(2012) Koutaro Ishibashi et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

(2012) S. Menon et al.   Science Signaling

Inverse Association Between Serum Free Thyroxine Levels and Hepatic Steatosis: Results from the Study of Health in Pomerania

(2012) Till Ittermann et al.   THYROID

Circadian autophagy rhythm: a link between clock and metabolism?

(2012) Di Ma et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection

(2011) Pierre-Emmanuel Rautou et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Autophagy as a rescue mechanism in Efavirenz-induced mitochondrial dysfunction: A lesson from hepatic cells

(2011) Nadezda Apostolova et al.   Autophagy

Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis

(2011) Ying-Hong Shi et al.   Autophagy

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment

(2011) Paul G. Thomes et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress induced by hepatitis B virus X protein enhances cyclo-oxygenase 2 expression via activating transcription factor 4

(2011) Hyun Kook Cho et al.   BIOCHEMICAL JOURNAL

Metabolic contribution of hepatic autophagic proteolysis: Old wine in new bottles

(2011) Takashi Ueno et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells

(2011) Tao Cui et al.   BRAIN RESEARCH

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

(2011) Lisa Kinch et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

SNARE Proteins Are Required for Macroautophagy

(2011) Usha Nair et al.   CELL

RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome Assembly

(2011) Brian O. Bodemann et al.   CELL

Autophagosome Precursor Maturation Requires Homotypic Fusion

(2011) Kevin Moreau et al.   CELL

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure

(2011) Yiping Huang et al.   CELL CYCLE

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Eating the strangers within: host control of intracellular bacteria via xenophagy

(2011) Leigh A. Knodler et al.   CELLULAR MICROBIOLOGY

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008

(2011) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

Mechanisms of fibrosis: the role of the pericyte

(2011) Claudia Schrimpf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

(2011) Di Ma et al.   EMBO JOURNAL

microRNA-101 is a potent inhibitor of autophagy

(2011) Lisa B Frankel et al.   EMBO JOURNAL

The emerging role of autophagy in alcoholic liver disease

(2011) Wen-Xing Ding et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Differential, Type I Interferon-Mediated Autophagic Trafficking of Hepatitis C Virus Proteins in Mouse Liver

(2011) Mayura M. Desai et al.   GASTROENTEROLOGY

Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice

(2011) Jin–Hee Wang et al.   GASTROENTEROLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Autophagy Protects Cells From HCV-Induced Defects in Lipid Metabolism

(2011) Tiziana Vescovo et al.   GASTROENTEROLOGY

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

(2011) J. Kluwe et al.   GUT

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy

(2011) Nadezda Apostolova et al.   HEPATOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma

(2011) Satoshi Shimizu et al.   INTERNATIONAL JOURNAL OF CANCER

Crucial role for autophagy in degranulation of mast cells

(2011) Hiroko Ushio et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Flavivirus NS4A-induced Autophagy Protects Cells against Death and Enhances Virus Replication

(2011) Jeffrey E. McLean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Activation of unfolded protein response and autophagy during HCV infection modulates innate immune response

(2011) Emilie Estrabaud et al.   JOURNAL OF HEPATOLOGY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Autophagy Required for Hepatitis B Virus Replication in Transgenic Mice

(2011) Y. Tian et al.   JOURNAL OF VIROLOGY

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

(2011) J. Li et al.   JOURNAL OF VIROLOGY

Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy

(2011) W.-C. Su et al.   JOURNAL OF VIROLOGY

Dysfunction of Autophagy Participates in Vacuole Formation and Cell Death in Cells Replicating Hepatitis C Virus

(2011) S. Taguwa et al.   JOURNAL OF VIROLOGY

Manipulation or capitulation: virus interactions with autophagy

(2011) Tristan X. Jordan et al.   MICROBES AND INFECTION

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Circadian Metabolic Regulation through Crosstalk between Casein Kinase 1δ and Transcriptional Coactivator PGC-1α

(2011) Siming Li et al.   MOLECULAR ENDOCRINOLOGY

Endoplasmic reticulum stress induces autophagy through activation of p38 MAPK in fibroblasts from Pompe disease patients carrying c.546G>T mutation

(2011) Yohta Shimada et al.   MOLECULAR GENETICS AND METABOLISM

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Persistent Expression of Hepatitis C Virus Non-Structural Proteins Leads to Increased Autophagy and Mitochondrial Injury in Human Hepatoma Cells

(2011) Victor C. Chu et al.   PLoS One

Transgenic Expression of Entire Hepatitis B Virus in Mice Induces Hepatocarcinogenesis Independent of Chronic Liver Injury

(2011) Bing Na et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Dengue Virus and Autophagy

(2011) Nicholas S. Heaton et al.   Viruses-Basel

Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes

(2011) D Degli Esposti et al.   Cell Death & Disease

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation

(2010) Insil Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Systems Biology of Mammalian Circadian Clocks

(2010) Hideki Ukai et al.   Annual Review of Physiology

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy Selectively Degrades Individual Damaged Mitochondria After Photoirradiation

(2010) Insil Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells

(2010) Raquel S. Carreira et al.   Autophagy

Autophagy by hepatitis B virus and for hepatitis B virus

(2010) Donna Sir et al.   Autophagy

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

(2010) Yongjun Wang et al.   HEPATOLOGY

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

(2010) Felix Stickel et al.   HEPATOLOGY

Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

(2010) Shubham Shrivastava et al.   HEPATOLOGY

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

A Role for Toll-like Receptor 3 Variants in Host Susceptibility to Enteroviral Myocarditis and Dilated Cardiomyopathy

(2010) Carlos Gorbea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Regulation of innate immune responses by autophagy-related proteins

(2010) Tatsuya Saitoh et al.   JOURNAL OF CELL BIOLOGY

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

(2010) Po-Yuan Ke et al.   JOURNAL OF CLINICAL INVESTIGATION

Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

(2010) P. Ferraris et al.   JOURNAL OF GENERAL VIROLOGY

In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C

(2010) Tarik Asselah et al.   JOURNAL OF PATHOLOGY

Autophagy in viral replication and pathogenesis

(2010) Donna Sir et al.   MOLECULES AND CELLS

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication

(2010) D. Sir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection

(2010) Carl Guévin et al.   VIROLOGY

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes

(2009) Sara Rodriguez-Enriquez et al.   Autophagy

Knockdown of autophagy-related gene decreases the production of infectious Hepatitis C virus particles

(2009) Isei Tanida et al.   Autophagy

The MAP1-LC3 conjugation system is involved in lipid droplet formation

(2009) Masahiro Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Morphogenesis of hepatitis B virus and its subviral envelope particles

(2009) Romuald Patient et al.   CELLULAR MICROBIOLOGY

Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression

(2009) Gary L. Davis et al.   GASTROENTEROLOGY

Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury

(2009) Jon Cardinal et al.   HEPATOLOGY

Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion

(2009) Nadine Huber et al.   HEPATOLOGY

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy

(2009) Tomokazu Mizui et al.   JOURNAL OF GASTROENTEROLOGY

Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes

(2009) M. Panyasrivanit et al.   JOURNAL OF GENERAL VIROLOGY

A role for autophagolysosomes in dengue virus 3 production in HepG2 cells

(2009) A. Khakpoor et al.   JOURNAL OF GENERAL VIROLOGY

Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning

(2009) Thomas Minor et al.   LIVER TRANSPLANTATION

Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy

(2009) W.-X. Ding et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy in tumour suppression and promotion

(2009) Andreas Brech et al.   Molecular Oncology

Another way to get rid of fat

(2009) Rudolf Zechner et al.   NATURE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Variant in PNPLA3 is associated with alcoholic liver disease

(2009) Chao Tian et al.   NATURE GENETICS

Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection

(2009) Luc English et al.   NATURE IMMUNOLOGY

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Measurement of internal body time by blood metabolomics

(2009) Y. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

(2008) Angeles Duran et al.   CANCER CELL

Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in α-1-antitrypsin deficiency

(2008) D H Perlmutter   CELL DEATH AND DIFFERENTIATION

Cell biology of lipid droplets

(2008) Christoph Thiele et al.   CURRENT OPINION IN CELL BIOLOGY

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

(2008) Jae-Sung Kim et al.   HEPATOLOGY

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

(2008) Hong Tang et al.   HEPATOLOGY

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

(2008) Jacquelyn J. Maher et al.   HEPATOLOGY

Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation

(2008) Masaru Harada et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

(2008) Chong-Shan Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Autophagic machinery activated by dengue virus enhances virus replication

(2008) Ying-Ray Lee et al.   VIROLOGY

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY