Article
Pharmacology & Pharmacy
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Summary: In this study, it was found that Methylsulfonylmethane (MSM) can enhance the autophagy flux through the AMPK/mTOR/ULK1 pathway, improving hepatic steatosis and potentially serving as a treatment for obesity-related MAFLD.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Cell Biology
Cansu Karabiyik, David C. Rubinsztein
Summary: During glucose starvation, activation of AMPK, ULK1, and PIKFYVE kinases via a non-canonical signaling pathway leads to the formation of autophagosomes containing PtdIns5P, increasing autophagy flux and facilitating the clearance of autophagy substrates.
Article
Chemistry, Medicinal
Di Zhang, Yinghui Zhang, Zhilan Wang, Lei Lei
Summary: This study demonstrates the beneficial effects of thymoquinone (TQ) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) and human hepatocellular carcinoma cells. TQ promotes hepatic autophagy through the AMPK/mTOR/ULK1 signaling pathway, reducing lipid accumulation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Environmental Sciences
Yinyue Luo, Dongxin Da, Qingqing Weng, Shuran Yao, Hao Zhang, Xinxin Han, Ying Zhang
Summary: This study found that overexpression of miR-296-5p can accelerate autophagy in fluoride-induced dental fluorosis, while its underexpression has an inhibitory effect on autophagy. MiR-296-5p may improve the secretion of autophagic mediators by activating AMPK/ULK1 expression, suggesting it as a potential therapeutic target under high fluoride stimulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Geriatrics & Gerontology
Jia Song, Jidong Liu, Chen Cui, Huiqing Hu, Nan Zang, Mengmeng Yang, Jingwen Yang, Ying Zou, Jinquan Li, Lingshu Wang, Qin He, Xinghong Guo, Ruxing Zhao, Fei Yan, Fuqiang Liu, Xinguo Hou, Zheng Sun, Li Chen
Summary: Human umbilical cord mesenchymal stromal cells (hucMSCs) and hucMSC-derived exosomes (MSC-EXO) can alleviate diabetes- and obesity-induced muscle atrophy by enhancing AMPK/ULK1-mediated autophagy, suggesting their potential as a treatment for muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Multidisciplinary Sciences
Qing-Bo Lu, Yi Ding, Yao Liu, Zi-Chao Wang, Yu-Jie Wu, Kai -Ming Niu, Ke-Xue Li, Ji -Ru Zhang, Hai-Jian Sun
Summary: Metrnl plays a protective role in diabetic cardiomyopathy and may serve as a therapeutic target or regimen.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Immunology
Juan Xiao, Xiaofang Shen, Ruiming Kou, Ke Wang, Lihong Zhai, Lu Ding, Huabo Chen, Chun Mao
Summary: This study aimed to investigate the protective role of kirenol in inflammation induced by lipopolysaccharide (LPS) in acute lung injury (ALI) cell and mouse models and unravel the underlying mechanisms, with a particular focus on autophagy. The results showed that kirenol could significantly inhibit inflammatory cytokines secretion and enhance autophagy, possibly through activating the AMPK-mTOR-ULK1 pathway. RNA sequencing results suggested the involvement of kirenol in acute inflammatory response and the AMPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zi-ang Yao, Ling Xu, Li-ming Jin, Tian-sheng Wang, Bai-xiang Wang, Jiang-zhou Li, Ying Bai, Hai-ge Wu
Summary: KOS can protect microglia from over-activated inflammation by inducing autophagy and inhibiting the release of inflammatory cytokines. Additionally, KOS can regulate the autophagy pathway and inhibit the inflammatory response of over-activated microglia by reducing the expression of proteins related to the AMPK/ULK1 pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Zhao-Ling Qin, Qiu-Feng Yao, Ping Zhao, Hao Ren, Zhong-Tian Qi
Summary: This study found that ZIKV infection induces lipophagy through activation of the AMPK-ULK1 signaling pathway, leading to a decrease in lipid droplet size and triglyceride content, as well as an increase in lysosomal biosynthesis and LD-lysosome fusion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Pan, Shi-jie Li, Hua Guo, Zhao-hui Li, Xiang Fei, Shi-min Chang, Qing-cheng Yang, Dong-dong Cheng
Summary: Numerous studies have shown that anti-inflammatory agents can have antitumor effects in cancer therapy by directly increasing apoptosis and sensitivity to therapies, and decreasing invasion and metastasis. In this study, ebastine, a H1-histamine receptor antagonist, was screened and found to have antitumor effects in osteosarcoma cells. Ebastine treatment induced cell cycle arrest, inhibited metastasis, and induced apoptosis and autophagy both in vitro and in vivo. Mechanistically, ebastine activated the AMPK/ULK1 signaling pathway, triggering proapoptotic autophagy. IPMK was identified as a positive regulator of AMPK in osteosarcoma cells, and IPMK knockdown reversed the effects of ebastine on autophagy and AMPK/ULK1 signaling. This study suggests that ebastine has potential as a therapeutic candidate for osteosarcoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Hui Shen, Yan Sha, Jun Huang, An-Qi Mao, Tao Zhang, Mu-Yao Wu, Fang Sun, Ying-Yuan Yu, Zhong-Qin Cheng, Ya-Ting Gong
Summary: This study found that AMPK affects the development of psoriasis in a mouse model by regulating autophagy and mitochondrial autophagy. Upregulation of AMPK signaling pathway leads to increased autophagy and mitochondrial autophagy, which can alleviate skin lesions in the mouse model; while downregulation of AMPK signaling pathway exacerbates psoriasis-like skin lesions.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Yingchao Liang, Beili Wang, Xiaowen Pu, Xiaoxiong Wu, Liang Yang
Summary: This study found that Britannin can inhibit the proliferation, invasion, and migration of cervical cancer cells and promote the generation of ROS and autophagy. The mechanism may involve the ROS/AMPK/ULK1 signaling pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiqiang Zhang, Lei Chen, Xueheng Chen, Yiran Qin, Chao Tian, Xuening Dai, Runqi Meng, Yuanyuan Zhong, Wenyan Liang, Cheng Shen, Jinguo Zhang, Bin Zhang, Xiqing Wei
Summary: Diabetic cardiomyopathy is a cardiovascular disease caused by diabetes, with a high incidence, complex pathophysiology, and poor treatment outcomes. Autophagy, inflammation, and mitochondrial damage have been identified as key factors in the development of diabetic cardiomyopathy. Human umbilical cord mesenchymal stem cells-derived exosomes show potential in repairing and protecting cardiomyocytes. This study evaluated the therapeutic benefits of HUCMSC-EXO for diabetic cardiomyopathy and explored their mechanisms of action.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Teng Ma, Xiangpeng Wang, Wenjing Qu, Lingsen Yang, Cheng Jing, Bingrui Zhu, Yongkui Zhang, Wenpeng Xie
Summary: The study showed that osthole can inhibit the progression of KOA by activating autophagy in rat chondrocytes, potentially involving the AMPK/ULK1 signaling pathway. Osthole may be a novel and effective therapeutic agent for clinical treatment of KOA.
Article
Reproductive Biology
Jing Pang, Hua Yang, Xu Feng, Qi Wang, Yu Cai, Zifei Liu, Changjian Wang, Feng Wang, Yanli Zhang
Summary: HT-2 toxin exerts toxic effects on goat spermatogonial stem cells, leading to decreased cell viability and proliferation, disruption of self-renewal ability, and induction of cell apoptosis and oxidative stress. Additionally, HT-2 toxin exposure also induces autophagy in goat SSCs, possibly through the AMPK-mTOR-ULK1 pathway.