Article
Agriculture, Multidisciplinary
Shuhua Tian, Yunfan Wang, Xiangfei Li, Jie Liu, Jing Wang, Yingjian Lu
Summary: Sulforaphane (SFN) can alleviate obesity complications through various mechanisms, including reducing NAFLD, inflammation, oxidative stress, adipose tissue hypertrophy, and insulin resistance, as well as regulating glucose and lipid metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mengxiao Wang, Bingbing Li, Fujian Qin, Junmei Ye, Liang Jin
Summary: This study reveals the significant role of Ext1 in the progression of non-alcoholic fatty liver disease (NAFLD) by modulating ER homeostasis and insulin resistance in hepatocytes. The findings suggest a new potential therapeutic target for NAFLD through targeting Ext1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Heeseung Oh, Wonjun Cho, A. M. Abd El-Aty, Cemil Bayram, Ji Hoon Jeong, Tae Woo Jung
Summary: This study found that RD3 alleviates insulin resistance in skeletal muscle and hepatic steatosis through the AMPK/autophagy signaling pathway, providing a new therapeutic approach for treating metabolic disorders.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Mavromati, Francois R. Jornayvaz
Summary: Hypothyroidism can lead to dyslipidemia and NAFLD, with potential effectiveness of selective THR-beta agonists in treatment. Interest in therapeutic options targeting these receptors is growing as evidence of their association accumulates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Akira Yoshii, Haruka Kimura, Keiichi Ito, Yusuke Kashiwagi, Toshikazu D. Tanaka, Michihiro Yoshimura
Summary: The study demonstrates that a novel URAT1-selective inhibitor, dotinurad, has a significant therapeutic effect in HFD-induced obese mice, reducing hepatic steatosis and promoting BAT rebrowning.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Sandro Altamura, Katja Muedder, Andrea Schlotterer, Thomas Fleming, Elena Heidenreich, Ruiyue Qiu, Hans-Peter Hammes, Peter Nawroth, Martina U. Muckenthaler
Summary: The study reveals that hepatic iron accumulation may exacerbate symptoms related to metabolic syndrome and type 2 diabetes. It suggests that iron depletion strategies in combination with anti-diabetic drugs could potentially improve insulin resistance and diabetic late complications.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Furong He, Mei Wang, Hairong Zhao, De Xie, Jiaming Lv, Weidong Liu, Wei Yu, Qiang Wang, Binyang Chen, Chenxi Xu, Tetsuya Yamamoto, Hidenori Koyama, Jidong Cheng
Summary: Uric acid is closely related to hepatic insulin resistance, and autophagy plays a protective role in obesity-related hepatic insulin resistance. This study reveals that high uric acid levels induce hepatic insulin resistance and enhance autophagy degradation. Activating autophagy can alleviate high uric acid-induced insulin resistance, while inhibiting autophagy can worsen insulin resistance. The AMPK alpha-mTOR pathway may be involved in high uric acid-induced autophagy. The findings suggest a potential therapeutic target for hepatic insulin resistance derived from high uric acid.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yanqiu Zhang, Shengtao Ye, Weijia Lu, Jiawen Zhong, Yingrong Leng, Ting Yang, Jun Luo, Wenjun Xu, Hao Zhang, Lingyi Kong
Summary: DDX5 is downregulated in NASH and plays a role in lipid metabolism and inflammation by regulating mTORC1 activation. The phytochemical compound hyperforcinol K interacts with DDX5 and reduces lipid accumulation and inflammation, providing potential targets and a promising lead compound for NASH treatment.
Article
Endocrinology & Metabolism
Xiaolin Ye, Yang Liu, Jiajin Hu, Yanyan Gao, Yanan Ma, Deliang Wen
Summary: This study investigated the effects of chlorogenic acid (CGA) found in coffee on obesity and metabolic endotoxemia. CGA was found to prevent weight gain, improve intestinal barrier function, and prevent metabolic disorders and endotoxemia through altering the gut microbiota composition. The study concludes that CGA-induced changes in the gut microbiota play a key role in inhibiting metabolic endotoxemia in high-fat diet-fed mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Sitara Niranjan, Brett E. E. Phillips, Nick Giannoukakis
Summary: Diabetes mellitus is a metabolic disease characterized by hyperglycemia. It is becoming a common condition associated with liver disease in the US. The mechanism by which diabetes drives liver disease is a hot topic of discussion and research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marieh Salavatizadeh, Samira Soltanieh, Amirhossein Ataei Kachouei, Zahra Abdollahi Fallahi, Hamed Kord-Varkaneh, Hossein Poustchi, Asieh Mansour, Mohammad E. Khamseh, Fariba Alaei-Shahmiri, Heitor O. Santos, Azita Hekmatdoost
Summary: Dietary glycemic index (GI) is associated with the odds of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). Higher GI diets are associated with increased risk of NAFLD in individuals with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Svetlana Spremovic Radenovic, Miljan Pupovac, Mladen Andjic, Jovan Bila, Svetlana Sreckovic, Aleksandra Gudovic, Biljana Dragas, Nebojsa Radunovic
Summary: This review presents the current knowledge in epidemiology, pathophysiology, diagnostics, and treatment of nonalcoholic fatty liver disease (NAFLD) in polycystic ovary syndrome (PCOS) women. It highlights the associations of insulin resistance, hyperandrogenemia, obesity, adipose tissue dysfunction, and inflammation with the development of NAFLD in PCOS women. Additionally, the possible roles of the gut microbiome, mitochondrial dysfunction, and endocannabinoid system in NAFLD maintenance in PCOS women are discussed.
Review
Nutrition & Dietetics
Nella Polidori, Eleonora Agata Grasso, Francesco Chiarelli, Cosimo Giannini
Summary: The impaired plasmatic levels of BCAAs in obese children and adolescents are associated with obesity-related metabolic disorders, potentially through the activation of the mTORC1 complex causing insulin resistance, and the accumulation of toxic metabolites leading to mitochondrial dysfunction and damage to pancreatic cells. These compounds may help in the early identification of complications related to pediatric obesity, but further studies are needed.
Article
Medicine, Research & Experimental
Sahib Zada, Trang Minh Pham, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Omar Elashkar, Jung-Hwan Kim, Dong Hee Kim, Deok Ryong Kim
Summary: The study demonstrates that chlorogenic acid (CGA) protects human chondrocytes against H2O2-induced apoptosis by decreasing apoptosis markers, increasing anti-apoptotic markers, and activating antioxidant response proteins through autophagy induction.
Article
Multidisciplinary Sciences
Ying Mei, Hui Hu, Liangjun Deng, Xiaoou Sun, Wen Tan
Summary: This study found that STVNa can improve NAFLD by activating autophagy, reducing inflammation and lipid accumulation, and inhibiting hepatic oxidative stress and fibrosis. Therefore, STVNa may be an alternative therapeutic agent for NAFLD.
SCIENTIFIC REPORTS
(2022)