miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function

(2016) Chang Yeob Han et al.   ARCHIVES OF PHARMACAL RESEARCH

Novel Pharmacotherapy Options for NASH

(2016) Vlad Ratziu   DIGESTIVE DISEASES AND SCIENCES

Role of MicroRNAs in NAFLD/NASH

(2016) Gyongyi Szabo et al.   DIGESTIVE DISEASES AND SCIENCES

Stress-activatedmiR-21/miR-21*in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption

(2016) Nicolas Calo et al.   GUT

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Erratum: Corrigendum: Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis

(2016) Pedro M. Rodrigues et al.   Scientific Reports

Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma

(2016) Marta Afonso et al.   Journal of Clinical Medicine

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway

(2015) Heng Wu et al.   GUT

Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

(2015) Xavier Loyer et al.   GUT

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The oncogenic microRNA miR-21 promotes regulated necrosis in mice

(2015) Xiaodong Ma et al.   Nature Communications

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease

(2014) Duarte M. S. Ferreira et al.   FEBS Journal

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis

(2013) Erika Segear Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HCV Infection and Miravirsen

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Delivering the promise of miRNA cancer therapeutics

(2012) Diane M. Pereira et al.   DRUG DISCOVERY TODAY

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease

(2012) Rui E. Castro et al.   JOURNAL OF HEPATOLOGY

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease

(2011) Marcos Martínez-Clemente et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Recent advances in nonalcoholic fatty liver disease

(2009) Onpan Cheung et al.   CURRENT OPINION IN GASTROENTEROLOGY

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice

(2009) Bo Wang et al.   HEPATOLOGY

Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-α expression, a novel mechanism for the pathogenesis of NAFLD

(2009) Lin Zheng et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Alleviation of High-Fat Diet-Induced Fatty Liver Damage in Group IVA Phospholipase A2-Knockout Mice

(2009) Hiromi Ii et al.   PLoS One

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression

(2008) Onpan Cheung et al.   HEPATOLOGY

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

(2008) Manlio Vinciguerra et al.   HEPATOLOGY

Animal models of NASH: Getting both pathology and metabolic context right

(2008) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

(2008) B. Kong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS