Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

Towards chamber specific heart-on-a-chip for drug testing applications

(2020) Yimu Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium‐on‐a‐Chip Application

(2020) Shreya Mehrotra et al.   ADVANCED FUNCTIONAL MATERIALS

Heart-on-a-chip Model with Integrated Extra- and Intra-cellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia

(2020) Haitao Liu et al.   NANO LETTERS

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing

(2020) Benedetta Artegiani et al.   NATURE CELL BIOLOGY

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

(2020) Elaheh Karbassi et al.   Nature Reviews Cardiology

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

(2020) Sonia Shah et al.   Nature Communications

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Blinded, multi-centre evaluation of drug-induced changes in contractility using human induced pluripotent stem cell-derived cardiomyocytes

(2020) Umber Saleem et al.   TOXICOLOGICAL SCIENCES

3D microgroove electrical impedance sensing to examine 3D cell cultures for antineoplastic drug assessment

(2020) Yuxiang Pan et al.   Microsystems & Nanoengineering

Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip

(2020) Jaimeson Veldhuizen et al.   BIOMATERIALS

Fabrication of a Perfusable 3D In Vitro Artery-Mimicking Multichannel System for Artery Disease Models

(2020) Minkyung Cho et al.   ACS Biomaterials-Science & Engineering

Cardiac Fibrotic Remodeling on a Chip with Dynamic Mechanical Stimulation

(2019) Ming Kong et al.   Advanced Healthcare Materials

Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology

(2019) Jihoon Kim et al.   Viruses-Basel

Hydrogel Microchambers Integrated with Organic Electrodes for Efficient Electrical Stimulation of Human iPSC‐Derived Cardiomyocytes

(2019) Shotaro Yoshida et al.   MACROMOLECULAR BIOSCIENCE

User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip

(2019) Oliver Schneider et al.   TISSUE ENGINEERING PART A

Microfluidic Fabrication of Biomimetic Helical Hydrogel Microfibers for Blood‐Vessel‐on‐a‐Chip Applications

(2019) Luanluan Jia et al.   Advanced Healthcare Materials

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

(2019) Haitao Liu et al.   ADVANCED MATERIALS

Vascular smooth muscle cells in atherosclerosis

(2019) Gemma L. Basatemur et al.   Nature Reviews Cardiology

Genomic and Transcriptomic Association Studies Identify 16 Novel Susceptibility Loci for Venous Thromboembolism

(2019) Sara Lindstrom et al.   BLOOD

Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association

(2019) Gary Gintant et al.   CIRCULATION RESEARCH

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

(2019) Kevin Achberger et al.   eLife

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Development of a Next-Generation Biosensing Platform for Simultaneous Detection of Mechano- and Electrophysiology of the Drug-Induced Cardiomyocytes

(2019) Nomin-Erdene Oyunbaatar et al.   ACS Sensors

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

(2019) Derek Klarin et al.   NATURE GENETICS

Generation of blood vessel organoids from human pluripotent stem cells

(2019) Reiner A. Wimmer et al.   Nature Protocols

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Automated Analysis of Platelet Aggregation on Cultured Endothelium in a Microfluidic Chip Perfused with Human Whole Blood

(2019) Albers et al.   Micromachines

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

(2019) Olya Mastikhina et al.   BIOMATERIALS

Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study

(2019) Sanne L.N. Brouns et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

(2019) Kuo-Chan Weng et al.   TISSUE ENGINEERING PART C-METHODS

Multifunctional 3D electrode platform for real-time in situ monitoring and stimulation of cardiac tissues

(2018) Ning Zhang et al.   BIOSENSORS & BIOELECTRONICS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

(2018) Riccardo Barrile et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

(2018) Yongzhi Qiu et al.   Nature Biomedical Engineering

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting

(2018) David G. Strauss et al.   Therapeutic Innovation & Regulatory Science

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Cardiovascular disease models: A game changing paradigm in drug discovery and screening

(2018) Houman Savoji et al.   BIOMATERIALS

Detection of long non–coding RNA homology, a comparative study on alignment and alignment–free metrics

(2018) Teresa M. R. Noviello et al.   BMC BIOINFORMATICS

Heart on a chip: Micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering

(2018) Maria Kitsara et al.   MICROELECTRONIC ENGINEERING

Toward a CRISPR Picture: Use of CRISPR/Cas9 to Model Diseases in Human Stem Cells In Vitro

(2017) Jamie L. Freiermuth et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A microfluidic platform for the high-throughput study of pathological cardiac hypertrophy

(2017) Hesam Parsa et al.   LAB ON A CHIP

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

(2017) Fang Qian et al.   LAB ON A CHIP

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

(2017) Ben M. Maoz et al.   LAB ON A CHIP

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

(2017) Pedro F. Costa et al.   LAB ON A CHIP

Simultaneous monitoring of single cell and of micro-organ activity by PEDOT:PSS covered multi-electrode arrays

(2017) Dimitrios A. Koutsouras et al.   Materials Science & Engineering C-Materials for Biological Applications

Association analyses based on false discovery rate implicate new loci for coronary artery disease

(2017) Christopher P Nelson et al.   NATURE GENETICS

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro

(2017) Ken-ichiro Kamei et al.   RSC Advances

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

(2017) Leigh Atchison et al.   Scientific Reports

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

(2017) Genevieve Conant et al.   Stem Cell Reviews and Reports

Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification

(2017) Eugene K. Lee et al.   Stem Cell Reports

The electrophysiological development of cardiomyocytes

(2016) Jie Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

(2016) Abhishek Jain et al.   BIOMEDICAL MICRODEVICES

In microfluidico: Recreating in vivo hemodynamics using miniaturized devices

(2016) Shu Zhu et al.   BIORHEOLOGY

Heart-on-a-chip based on stem cell biology

(2016) Elzbieta Jastrzebska et al.   BIOSENSORS & BIOELECTRONICS

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

(2016) Michael F. Wells et al.   Cell Stem Cell

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

Drugs That May Cause or Exacerbate Heart Failure

(2016) Robert L. Page et al.   CIRCULATION

Cardiovascular disease in Europe: epidemiological update 2016

(2016) Nick Townsend et al.   EUROPEAN HEART JOURNAL

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function

(2016) Abhishek Jain et al.   Nature Communications

Laminar ventricular myocardium on a microelectrode array-based chip

(2016) Ville J. Kujala et al.   Journal of Materials Chemistry B

Cytostretch, an Organ-on-Chip Platform

(2016) Nikolas Gaio et al.   Micromachines

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

A multilayered microfluidic blood vessel-like structure

(2015) Anwarul Hasan et al.   BIOMEDICAL MICRODEVICES

User-friendly 3D bioassays with cell-containing hydrogel modules: narrowing the gap between microfluidic bioassays and clinical end-users' needs

(2015) Do-Hyun Lee et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

“Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions”

(2015) Robert G. Mannino et al.   Scientific Reports

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

(2014) Sanjay Sinha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells

(2014) David G. Belair et al.   Stem Cell Reviews and Reports

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Pathological Ventricular Remodeling

(2013) Jana S. Burchfield et al.   CIRCULATION

Microfluidic heart on a chip for higher throughput pharmacological studies

(2013) Ashutosh Agarwal et al.   LAB ON A CHIP

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays

(2013) Yu-Hsiang Hsu et al.   LAB ON A CHIP

A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions

(2013) Michelle B. Chen et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels

(2012) Yoojin Shin et al.   Nature Protocols

Monitoringin vitrothrombus formation with novel microfluidic devices

(2012) Erik Westein et al.   PLATELETS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Endothelium—role in regulation of coagulation and inflammation

(2011) Victor W. M. van Hinsbergh   Seminars in Immunopathology

Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

(2010) Izhak Kehat et al.   CIRCULATION

Induced pluripotency: history, mechanisms, and applications

(2010) M. Stadtfeld et al.   GENES & DEVELOPMENT

A microfluidic platform for probing small artery structure and function

(2010) Axel Günther et al.   LAB ON A CHIP

Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

(2009) Jianhua Zhang et al.   CIRCULATION RESEARCH

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

(2009) Adriana Albini et al.   JNCI-Journal of the National Cancer Institute

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

(2009) Francisco Javier Tovar-Lopez et al.   LAB ON A CHIP

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT