In microfluidico: Recreating in vivo hemodynamics using miniaturized devices

Fluid Mechanics of Blood Clot Formation

(2015) Aaron L. Fogelson et al.   Annual Review of Fluid Mechanics

Fibrin, γ′-Fibrinogen, and Transclot Pressure Gradient Control Hemostatic Clot Growth During Human Blood Flow Over a Collagen/Tissue Factor WoundSignificance

(2015) Ryan W. Muthard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow

(2015) S. Zhu et al.   BLOOD

A vascular injury model using focal heat-induced activation of endothelial cells

(2015) J. L. Sylman et al.   Integrative Biology

Pathological von Willebrand factor fibers resist tissue plasminogen activator and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation

(2015) B. A. Herbig et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The effect of corn trypsin inhibitor and inhibiting antibodies for FXIa and FXIIa on coagulation of plasma and whole blood: comment

(2015) S. Butenas et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet bioreactor-on-a-chip

(2014) J. N. Thon et al.   BLOOD

Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition

(2014) R. Li et al.   HAEMOPHILIA

The effect of corn trypsin inhibitor and inhibiting antibodies for FXIa and FXIIa on coagulation of plasma and whole blood

(2014) K. M. Hansson et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

(2014) Yongzhi Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs

(2014) Xuanwen Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contact activation of blood coagulation on a defined kaolin/collagen surface in a microfluidic assay

(2014) Shu Zhu et al.   THROMBOSIS RESEARCH

Microfluidics and Coagulation Biology

(2013) Thomas V. Colace et al.   Annual Review of Biomedical Engineering

Blood plasma separation in elevated dimension T-shaped microchannel

(2013) Siddhartha Tripathi et al.   BIOMEDICAL MICRODEVICES

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

Microfluidic Assay of Platelet Deposition on Collagen by Perfusion of Whole Blood from Healthy Individuals Taking Aspirin

(2013) R. Li et al.   CLINICAL CHEMISTRY

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates

(2013) C. Puy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Systems biology of coagulation

(2013) S. L. Diamond   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic assay of hemophilic blood clotting: distinct deficits in platelet and fibrin deposition at low factor levels

(2013) T. V. COLACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient

(2013) Ryan W. Muthard et al.   LAB ON A CHIP

Detection of platelet sensitivity to inhibitors of COX-1, P2Y1, and P2Y12 using a whole blood microfluidic flow assay

(2013) Ruizhi Li et al.   THROMBOSIS RESEARCH

High Content Evaluation of Shear Dependent Platelet Function in a Microfluidic Flow Assay

(2012) Ryan R. Hansen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Thrombus Growth and Embolism on Tissue Factor-Bearing Collagen Surfaces Under Flow

(2012) Thomas V. Colace et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood Clots Are Rapidly Assembled Hemodynamic Sensors

(2012) Ryan W. Muthard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multiscale prediction of patient-specific platelet function under flow

(2012) M. H. Flamm et al.   BLOOD

Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse

(2012) J. D. WELSH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding

(2012) A. J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relipidated Tissue Factor Linked to Collagen Surfaces Potentiates Platelet Adhesion and Fibrin Formation in a Microfluidic Model of Vessel Injury

(2011) Thomas V. Colace et al.   BIOCONJUGATE CHEMISTRY

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of Morphology of Platelet Aggregates Formed on Collagen Under Laminar Blood Flow

(2010) T. Colace et al.   ANNALS OF BIOMEDICAL ENGINEERING

Thrombin Flux and Wall Shear Rate Regulate Fibrin Fiber Deposition State during Polymerization under Flow

(2010) K.B. Neeves et al.   BIOPHYSICAL JOURNAL

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

von Willebrand factor self-association on platelet GpIb  under hydrodynamic shear: effect on shear-induced platelet activation

(2010) K. M. Dayananda et al.   BLOOD

P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions

(2010) S. F. Maloney et al.   Integrative Biology

Acquired von Willebrand Syndrome After Continuous-Flow Mechanical Device Support Contributes to a High Prevalence of Bleeding During Long-Term Support and at the Time of Transplantation

(2010) Nir Uriel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli

(2010) Manash S Chatterjee et al.   NATURE BIOTECHNOLOGY

Design Considerations for a Microfluidic Device to Quantify the Platelet Adhesion to Collagen at Physiological Shear Rates

(2009) Durga P. Sarvepalli et al.   ANNALS OF BIOMEDICAL ENGINEERING

Tuning the Elastic Modulus of Hydrated Collagen Fibrils

(2009) Colin A. Grant et al.   BIOPHYSICAL JOURNAL

Factor XI contributes to thrombin generation in the absence of factor XII

(2009) D. V. Kravtsov et al.   BLOOD

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Harry L. Goldsmith, Ph.D.

(2008) Scott L. Diamond et al.   ANNALS OF BIOMEDICAL ENGINEERING

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

(2008) U. M. Okorie et al.   BLOOD

Non-surgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease☆

(2008) Ulrich Geisen et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates

(2008) K. B. NEEVES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood

(2008) Keith B. Neeves et al.   LAB ON A CHIP

Thrombin generation, fibrin clot formation and hemostasis

(2008) Alisa S. Wolberg et al.   TRANSFUSION AND APHERESIS SCIENCE