High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair

(2016) Matthew E. Hartman et al.   ADVANCED DRUG DELIVERY REVIEWS

Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues

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Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function

(2016) Ron Feiner et al.   NATURE MATERIALS

OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology

(2016) Aleksandra Klimas et al.   Nature Communications

High throughput screening technologies for ion channels

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High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes

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Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro – Correlation between contraction force and electrophysiology

(2015) Marcelo C. Ribeiro et al.   BIOMATERIALS

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

2014 FDA drug approvals

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Could erlotinib treatment lead to acute cardiovascular events in patients with lung adenocarcinoma after chemotherapy failure?

(2015) Tulay Kus et al.   OncoTargets and Therapy

Printable elastic conductors with a high conductivity for electronic textile applications

(2015) Naoji Matsuhisa et al.   Nature Communications

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

(2015) Peter Loskill et al.   PLoS One

Engineering Adolescence

(2014) Xiulan Yang et al.   CIRCULATION RESEARCH

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells

(2014) Xiulan Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Advances in tissue engineering through stem cell-based co-culture

(2014) Nikolaos K. Paschos et al.   Journal of Tissue Engineering and Regenerative Medicine

Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2014) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Cardiac optogenetics

(2013) Emilia Entcheva   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes

(2013) Donghui Zhang et al.   BIOMATERIALS

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

(2013) N. Thavandiran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Electrophysiological Data From Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes to Functional Preclinical Safety Assays

(2013) Kate Harris et al.   TOXICOLOGICAL SCIENCES

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

Dynamic transcription factor activity profiling in 2D and 3D cell cultures

(2012) Abigail D. Bellis et al.   BIOTECHNOLOGY AND BIOENGINEERING

Clinical cardiac safety profile of nilotinib

(2012) T. D. Kim et al.   HAEMATOLOGICA

Risk of Heart Failure in Breast Cancer Patients After Anthracycline and Trastuzumab Treatment: A Retrospective Cohort Study

(2012) E. J. A. Bowles et al.   JNCI-Journal of the National Cancer Institute

Trastuzumab-Induced Cardiotoxicity: Heart Failure at the Crossroads

(2012) Partho P. Sengupta et al.   MAYO CLINIC PROCEEDINGS

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

(2012) Bozhi Tian et al.   NATURE MATERIALS

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function

(2011) Brian Liau et al.   BIOMATERIALS

The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle

(2011) Sara Hinds et al.   BIOMATERIALS

Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

(2011) Anupama Natarajan et al.   BIOMATERIALS

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

(2011) Nathaniel L. Tulloch et al.   CIRCULATION RESEARCH

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review

(2011) Carl-Fredrik Mandenius et al.   JOURNAL OF APPLIED TOXICOLOGY

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

(2011) Sebastian Schaaf et al.   PLoS One

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Developments in three-dimensional cell culture technology aimed at improving the accuracy ofin vitroanalyses

(2010) Daniel J. Maltman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

Recurrent myocardial infarction associated with gefitinib therapy

(2010) Donald R. Lynch et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Highly conductive, printable and stretchable composite films of carbon nanotubes and silver

(2010) Kyoung-Yong Chun et al.   Nature Nanotechnology

Cardiotoxicity induced by tyrosine kinase inhibitors

(2009) George S. Orphanos et al.   ACTA ONCOLOGICA

Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

(2009) Jonathan P. Piccini et al.   AMERICAN HEART JOURNAL

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

(2009) Stefan R. Braam et al.   Stem Cell Research

High-Content Drug Screening with Engineered Musculoskeletal Tissues

(2009) Herman Vandenburgh   TISSUE ENGINEERING PART B-REVIEWS

Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate

(2008) M. L. Telli et al.   ANNALS OF ONCOLOGY

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION

Blockade of the erbB2 Receptor Induces Cardiomyocyte Death through Mitochondrial and Reactive Oxygen Species-dependent Pathways

(2008) Leo I. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Toxicity of Sunitinib and Sorafenib in Patients With Metastatic Renal Cell Carcinoma

(2008) Manuela Schmidinger et al.   JOURNAL OF CLINICAL ONCOLOGY

An evaluation of the cardiotoxicity of imatinib mesylate

(2008) Antonio Luiz Ribeiro et al.   LEUKEMIA RESEARCH

Mechanisms of Myocyte Cytotoxicity Induced by the Multiple Receptor Tyrosine Kinase Inhibitor Sunitinib

(2008) B. B. Hasinoff et al.   MOLECULAR PHARMACOLOGY

Drug-screening platform based on the contractility of tissue-engineered muscle

(2008) Herman Vandenburgh et al.   MUSCLE & NERVE

Distinct roles of GSK-3  and GSK-3  phosphorylation in the heart under pressure overload

(2008) T. Matsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Electrophysiological Drug Testing Using Human Embryonic Stem Cell Derived Cardiomyocytes

(2008) Oren Caspi et al.   STEM CELLS AND DEVELOPMENT

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

(2008) Yvonne Will et al.   TOXICOLOGICAL SCIENCES