Vascular smooth muscle cells in atherosclerosis

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

(2019) Magnus Bäck et al.   Nature Reviews Cardiology

Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse Atherosclerosis

(2019) Ying Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Promoters to Study Vascular Smooth Muscle

(2019) Raja Chakraborty et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13)Highlights

(2018) Haixiang Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells

(2018) Kazunori Nakagawa et al.   ATHEROSCLEROSIS

Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis

(2018) Yusuke Osonoi et al.   Autophagy

New models to study vascular mural cell embryonic origin: implications in vascular diseases

(2018) Sanjay Sinha et al.   CARDIOVASCULAR RESEARCH

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Non-coding RNAs in vascular disease – from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

(2018) Jan Fiedler et al.   CARDIOVASCULAR RESEARCH

Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis

(2018) Aarti Shah et al.   CIRCULATION

Myeloid cell contributions to cardiovascular health and disease

(2018) Matthias Nahrendorf   NATURE MEDICINE

Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice

(2018) Delphine Gomez et al.   NATURE MEDICINE

Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification

(2018) Olivier Espitia et al.   PLoS One

An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm

(2018) Christian L. Lino Cardenas et al.   Nature Communications

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells

(2018) Ashish Misra et al.   Nature Communications

Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension

(2018) Abdul Q. Sheikh et al.   Cell Reports

Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci

(2018) Boxiang Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

(2018) Lei Zhang et al.   Annual Review of Genetics

Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing

(2018) Valentina Lo Sardo et al.   CELL

A Novel Angiotensin II–Induced Long Noncoding RNA Giver Regulates Oxidative Stress, Inflammation, and Proliferation in Vascular Smooth Muscle Cells

(2018) Sadhan Das et al.   CIRCULATION RESEARCH

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

(2018) Lina Dobnikar et al.   Nature Communications

Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

(2018) Dharini Iyer et al.   PLoS Genetics

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

(2017) Sarah R. Langley et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system

(2017) H. Kaur et al.   Nature Communications

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability

(2017) Iraide Alloza et al.   Scientific Reports

The Yin–Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular RemodelingHighlights

(2016) Jianhui Zhuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β ProductionHighlights

(2016) Nicolle Ceneri et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lineage tracing of cells involved in atherosclerosis

(2016) Julián Albarrán-Juárez et al.   ATHEROSCLEROSIS

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease

(2016) Rafael Kramann et al.   Cell Stem Cell

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell ProliferationCLINICAL PERSPECTIVE

(2016) Margaret D. Ballantyne et al.   CIRCULATION

Reconciling Smooth Muscle Cell Oligoclonality and Proliferative Capacity in Experimental Atherosclerosis

(2016) Delphine Gomez et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

(2016) Joshua D. Hutcheson et al.   NATURE MATERIALS

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

(2016) Olga A Cherepanova et al.   NATURE MEDICINE

Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease

(2016) Gerard Pasterkamp et al.   Nature Reviews Cardiology

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

(2016) Clint L. Miller et al.   Nature Communications

Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability

(2016) Solene M. Evrard et al.   Nature Communications

Oxidized Low-Density Lipoprotein Increases Bone Sialoprotein Expression in Vascular Smooth Muscle Cells Via Runt-Related Transcription Factor 2

(2015) Effat Farrokhi et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Cholesterol Loading Reprograms the MicroRNA-143/145–Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like PhenotypeSignificance

(2015) Yuliya Vengrenyuk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis

(2015) Mandy OJ Grootaert et al.   Autophagy

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis

(2015) N. Rotllan et al.   CIRCULATION RESEARCH

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions

(2015) A.-X. Zhou et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

(2015) Sherine Ensan et al.   NATURE IMMUNOLOGY

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

(2015) Laura S Shankman et al.   NATURE MEDICINE

Pathophysiology of native coronary, vein graft and in-stent atherosclerosis

(2015) Kazuyuki Yahagi et al.   Nature Reviews Cardiology

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension

(2015) Abdul Q. Sheikh et al.   Science Translational Medicine

Alternation of histone and DNA methylation in human atherosclerotic carotid plaques

(2015) Rudolf Napieralski et al.   THROMBOSIS AND HAEMOSTASIS

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

(2015) Sylvia T. Nurnberg et al.   PLoS Genetics

Akt1 Regulates Vascular Smooth Muscle Cell Apoptosis Through FoxO3a and Apaf1 and Protects Against Arterial Remodeling and Atherosclerosis

(2014) Joanna Tucka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Increased atherosclerosis in mice with increased vascular biglycan content

(2014) Joel C. Thompson et al.   ATHEROSCLEROSIS

Calcifying vascular smooth muscle cells and osteoblasts: independent cell types exhibiting extracellular matrix and biomineralization-related mimicries

(2014) Rodrigo DAM Alves et al.   BMC GENOMICS

Contribution of Intimal Smooth Muscle Cells to Cholesterol Accumulation and Macrophage-Like Cells in Human Atherosclerosis

(2014) Sima Allahverdian et al.   CIRCULATION

Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis

(2014) Susanne Feil et al.   CIRCULATION RESEARCH

Targeted Reduction of Vascular Msx1 and Msx2 Mitigates Arteriosclerotic Calcification and Aortic Stiffness in LDLR-Deficient Mice Fed Diabetogenic Diets

(2014) S.-L. Cheng et al.   DIABETES

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Embryological-Origin–Dependent Differences in Homeobox Expression in Adult Aorta

(2013) Laia Trigueros-Motos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

(2013) Renjing Liu et al.   CIRCULATION

Smad2 and Myocardin-Related Transcription Factor B Cooperatively Regulate Vascular Smooth Muscle Differentiation From Neural Crest Cells

(2013) Wei-Bing Xie et al.   CIRCULATION RESEARCH

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Prelamin A Accelerates Vascular Calcification Via Activation of the DNA Damage Response and Senescence-Associated Secretory Phenotype in Vascular Smooth Muscle Cells

(2013) Yiwen Liu et al.   CIRCULATION RESEARCH

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Detection of histone modifications at specific gene loci in single cells in histological sections

(2013) Delphine Gomez et al.   NATURE METHODS

Smooth Muscle–Selective Inhibition of Nuclear Factor‐κB Attenuates Smooth Muscle Phenotypic Switching and Neointima Formation Following Vascular Injury

(2013) Tadashi Yoshida et al.   Journal of the American Heart Association

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study

(2012) Veena Naik et al.   CARDIOVASCULAR RESEARCH

Vascular Smooth Muscle Cell Sirtuin 1 Protects Against DNA Damage and Inhibits Atherosclerosis

(2012) Isabelle Gorenne et al.   CIRCULATION

Shear stress and advanced atherosclerosis in human coronary arteries

(2012) Frank Gijsen et al.   JOURNAL OF BIOMECHANICS

Adventitial Pericyte Progenitor/Mesenchymal Stem Cells Participate in the Restenotic Response to Arterial Injury

(2012) Ulrich Tigges et al.   JOURNAL OF VASCULAR RESEARCH

Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility

(2012) Christine Cheung et al.   NATURE BIOTECHNOLOGY

Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling

(2012) N. D. Pruett et al.   Biology Open

IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype

(2011) Jan H. von der Thüsen et al.   AMERICAN JOURNAL OF PATHOLOGY

SDF-1α Induction in Mature Smooth Muscle Cells by Inactivation of PTEN Is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation

(2011) Raphael A. Nemenoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone Marrow–Derived Smooth Muscle–Like Cells Are Infrequent in Advanced Primary Atherosclerotic Plaques but Promote Atherosclerosis

(2011) Haixiang Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular Smooth Muscle Progenitor Cells

(2011) Mark W. Majesky et al.   CIRCULATION RESEARCH

Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin

(2011) Margot Leroux-Berger et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Paracrine Osteogenic Signals via Bone Morphogenetic Protein-2 Accelerate the Atherosclerotic Intimal Calcification In Vivo

(2010) Yusuke Nakagawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

S100A12 in Vascular Smooth Muscle Accelerates Vascular Calcification in Apolipoprotein E–Null Mice by Activating an Osteogenic Gene Regulatory Program

(2010) Marion A. Hofmann Bowman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen

(2010) Jean-Philippe Coppé et al.   PLoS One

Absence of Akt1 Reduces Vascular Smooth Muscle Cell Migration and Survival and Induces Features of Plaque Vulnerability and Cardiac Dysfunction During Atherosclerosis

(2009) Carlos Fernández-Hernando et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

(2009) Suzhao Li et al.   CIRCULATION RESEARCH

Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3

(2009) A. Phillip Owens et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation

(2009) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

(2009) Kimberly R. Cordes et al.   NATURE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anatomic Demarcation of Cells: Genes to Patterns

(2009) H. Y. Chang   SCIENCE

Myocardin

(2008) Michael S. Parmacek   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

(2008) Hafid Ait-Oufella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Soluble N-Cadherin Overexpression Reduces Features of Atherosclerotic Plaque Instability

(2008) Cressida A. Lyon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans

(2008) Y. Nakashima et al.   CARDIOVASCULAR RESEARCH

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Developmental origin of smooth muscle cells in the descending aorta in mice

(2008) P. Wasteson et al.   DEVELOPMENT

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

(2008) J. N. Passman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY