Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Use and application of 3D-organoid technology

(2018) Benedetta Artegiani et al.   HUMAN MOLECULAR GENETICS

Adenovirus Infection of Human Enteroids Reveals Interferon Sensitivity and Preferential Infection of Goblet Cells

(2018) Mayumi K. Holly et al.   JOURNAL OF VIROLOGY

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

(2018) Hao Yin et al.   Nature Chemical Biology

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the Delivery System for CRISPR-Based Genome Editing

(2018) Zachary Glass et al.   TRENDS IN BIOTECHNOLOGY

Human organoid cultures: transformative new tools for human virus studies

(2018) Sasirekha Ramani et al.   Current Opinion in Virology

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant

(2018) Sabine M. G. van der Sanden et al.   Emerging Microbes & Infections

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

(2018) Sylvie Janssens et al.   mSystems

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

Recapitulation of hepatitis B virus–host interactions in liver organoids from human induced pluripotent stem cells

(2018) Yun-Zhong Nie et al.   EBioMedicine

Revolution in Gene Medicine Therapy and Genome Surgery

(2018) David J. Jiang et al.   Genes

Genome-wide approaches to unravelling host–virus interactions in Dengue and Zika infections

(2018) Aaron F Carlin et al.   Current Opinion in Virology

Toward a CRISPR Picture: Use of CRISPR/Cas9 to Model Diseases in Human Stem Cells In Vitro

(2017) Jamie L. Freiermuth et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A solvent- and vacuum-free route to large-area perovskite films for efficient solar modules

(2017) Han Chen et al.   NATURE

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

(2017) Janice S. Chen et al.   NATURE

One-step generation of conditional and reversible gene knockouts

(2017) Amanda Andersson-Rolf et al.   NATURE METHODS

Zika virus directly infects peripheral neurons and induces cell death

(2017) Yohan Oh et al.   NATURE NEUROSCIENCE

Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner

(2017) Coyne G. Drummond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Animal models of respiratory syncytial virus infection

(2017) Geraldine Taylor   VACCINE

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Alpha-defensin-dependent enhancement of enteric viral infection

(2017) Sarah S. Wilson et al.   PLoS Pathogens

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

(2016) Michael F. Wells et al.   Cell Stem Cell

Complex Tissue and Disease Modeling using hiPSCs

(2016) Robert Passier et al.   Cell Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

(2016) Jason Dang et al.   Cell Stem Cell

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

(2016) Hengli Tang et al.   Cell Stem Cell

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids

(2016) Amanda Andersson-Rolf et al.   DEVELOPMENTAL BIOLOGY

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

(2016) Evelyn Fessler et al.   EMBO Molecular Medicine

Zika virus and microcephaly: why is this situation a PHEIC?

(2016) David L Heymann et al.   LANCET

Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study

(2016) Guilherme Calvet et al.   LANCET INFECTIOUS DISEASES

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

(2016) Ryan J Park et al.   NATURE GENETICS

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zika Virus Associated with Microcephaly

(2016) Jernej Mlakar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

(2016) Feiran Zhang et al.   NUCLEIC ACIDS RESEARCH

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Comparative Analysis Between Flaviviruses Reveals Specific Neural Stem Cell Tropism for Zika Virus in the Mouse Developing Neocortex

(2016) Jean-Baptiste Brault et al.   EBioMedicine

Modeling rotavirus infection and antiviral therapy using primary intestinal organoids

(2015) Yuebang Yin et al.   ANTIVIRAL RESEARCH

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells

(2015) Xia Gao et al.   JOURNAL OF CELL BIOLOGY

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Efficient genetic engineering of human intestinal organoids using electroporation

(2015) Masayuki Fujii et al.   Nature Protocols

Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems

(2015) Marta Trevisan et al.   Viruses-Basel

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

(2015) Hongming Ma et al.   Cell Reports

CCR5 Disruption in Induced Pluripotent Stem Cells Using CRISPR/Cas9 Provides Selective Resistance of Immune Cells to CCR5-tropic HIV-1 Virus

(2015) HyunJun Kang et al.   Molecular Therapy-Nucleic Acids

Virus-Host Interactions: From Unbiased Genetic Screens to Function

(2015) Holly Ramage et al.   Annual Review of Virology

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Influenza Viruses En Route from Birds to Man

(2014) Hans Dieter Klenk   Cell Host & Microbe

The burden of norovirus gastroenteritis: an important foodborne and healthcare-related infection

(2014) G. Belliot et al.   CLINICAL MICROBIOLOGY AND INFECTION

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

(2014) Lin Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice are not men

(2014) H. Shaw Warren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

(2014) Dae-Sung Kim et al.   Frontiers in Cellular Neuroscience

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Epidemiology of human noroviruses and updates on vaccine development

(2013) Sasirekha Ramani et al.   CURRENT OPINION IN GASTROENTEROLOGY

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities

(2013) Kelvin KW To et al.   LANCET INFECTIOUS DISEASES

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

A developmental and genetic classification for malformations of cortical development: update 2012

(2012) A. James Barkovich et al.   BRAIN

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Human Induced Pluripotent Stem Cell-Derived Models to Investigate Human Cytomegalovirus Infection in Neural Cells

(2012) Leonardo D'Aiuto et al.   PLoS One

Modeling hepatitis C virus infection using human induced pluripotent stem cells

(2012) R. E. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during Differentiation

(2012) Xianfang Wu et al.   PLoS Pathogens

Genome-wide association studies and susceptibility to infectious diseases

(2011) M. J. Newport et al.   Briefings in Functional Genomics

Development and Evolution of the Human Neocortex

(2011) Jan H. Lui et al.   CELL

Population biological principles of drug-resistance evolution in infectious diseases

(2011) Pia Abel zur Wiesch et al.   LANCET INFECTIOUS DISEASES

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

Induced pluripotency: history, mechanisms, and applications

(2010) M. Stadtfeld et al.   GENES & DEVELOPMENT

Genome-Wide Identification of Susceptibility Alleles for Viral Infections through a Population Genetics Approach

(2010) Matteo Fumagalli et al.   PLoS Genetics

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Genome-wide association studies are coming for human infectious diseases

(2009) Sonia Davila et al.   Genome Medicine

Comparative Proteomic Phenotyping of Cell Lines and Primary Cells to Assess Preservation of Cell Type-specific Functions

(2008) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE