Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

(2016) Abhishek Jain et al.   BIOMEDICAL MICRODEVICES

Reverse Engineering Human Pathophysiology with Organs-on-Chips

(2016) Donald E. Ingber   CELL

Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity

(2016) Janette Bester et al.   Scientific Reports

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

Blocking α5β1 Integrin Attenuates sCD40L-Mediated Platelet Activation

(2015) Damir Simic et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study

(2015) Anthony Shock et al.   ARTHRITIS RESEARCH & THERAPY

Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases

(2014) J. H. Xie et al.   JOURNAL OF IMMUNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

(2013) D. B. Cines et al.   BLOOD

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Targeting the Platelet Integrin GPIIb/IIIa

(2011) Christoph E. Hagemeyer et al.   CURRENT PHARMACEUTICAL DESIGN

In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology

(2011) Michelle Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-CD40L Immune Complexes Potently Activate Platelets In Vitro and Cause Thrombosis in FCGR2A Transgenic Mice

(2010) L. Robles-Carrillo et al.   JOURNAL OF IMMUNOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Platelet CD154 Potentiates Interferon-  Secretion by Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus

(2010) P. Duffau et al.   Science Translational Medicine

CD40 and autoimmunity: The dark side of a great activator

(2009) Anna L. Peters et al.   SEMINARS IN IMMUNOLOGY

Arterial versus venous endothelial cells

(2008) Nathaniel G. dela Paz et al.   CELL AND TISSUE RESEARCH