The effects of metformin on autophagy

Metformin Suppresses LPS-Induced Inflammatory Responses in Macrophage and Ameliorates Allergic Contact Dermatitis in Mice via Autophagy

(2020) Mengjie Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study

(2020) Shipra Bhansali et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis

(2020) Ganhua You et al.   Drug Design Development and Therapy

Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration

(2020) Dong-Ming Zhou et al.   Aging-US

Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages

(2020) Beibei Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Metformin attenuates sevoflurane-induced neurocognitive impairment through AMPK-ULK1-dependent autophagy in aged mice

(2020) Zhu Jinpiao et al.   BRAIN RESEARCH BULLETIN

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials

(2020) Mohammad Jalali et al.   PHARMACOLOGICAL RESEARCH

Metformin as Host-Directed Therapy for TB Treatment: Scoping Review

(2020) Nikita Naicker et al.   Frontiers in Microbiology

Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells

(2020) Khawlah Athamneh et al.   Biomolecules

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway

(2019) Chao Niu et al.   Autophagy

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Metformin prevents cell tumorigenesis through autophagy-related cell death

(2019) Mauro De Santi et al.   Scientific Reports

Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes

(2019) Christopher A Wolff et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1

(2019) Sung-Hyun Hwang et al.   CANCER SCIENCE

Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo

(2019) Yong-li Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin Enhances Autophagy and Provides Cardioprotection in δ-Sarcoglycan Deficiency-Induced Dilated Cardiomyopathy

(2019) Hiromitsu Kanamori et al.   Circulation-Heart Failure

Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice

(2019) Chenglai Xia et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase

(2019) Yun Liu et al.   JOURNAL OF VASCULAR RESEARCH

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways

(2019) Yishi Wang et al.   LIFE SCIENCES

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway

(2019) Qingxue Li et al.   Food Science & Nutrition

Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation

(2019) Xiao-Wei Zhang et al.   Autophagy

Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway

(2019) Myungjin Jo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy as a molecular target for cancer treatment

(2019) Nur Mehpare Kocaturk et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Treatment with metformin and sorafenib alleviates endometrial hyperplasia in polycystic ovary syndrome by promoting apoptosis via synergically regulating autophagy

(2019) Qian-qing Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin inhibits angiogenesis of endothelial progenitor cells via miR-221-mediated p27 expression and autophagy

(2019) Hai-Zhen Ni et al.   Future Medicinal Chemistry

Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

(2019) Zhu Wang et al.   Cell and Bioscience

Autophagy in Kidney Disease

(2019) Mary E. Choi   Annual Review of Physiology

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells

(2019) Ljubica Vucicevic et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metformin‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition

(2019) Hengyi Chen et al.   Clinical Respiratory Journal

Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy

(2019) Bin Zhao et al.   Oxidative Medicine and Cellular Longevity

Curtailing PCOS

(2019) Selma Feldman Witchel et al.   PEDIATRIC RESEARCH

Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis

(2019) Jiang Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway

(2019) Ruijie Sun et al.   Cancer Medicine

Does Metformin Modulate Endoplasmic Reticulum Stress and Autophagy in Type 2 Diabetic Peripheral Blood Mononuclear Cells?

(2018) Noelia Diaz-Morales et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and function of autophagy in intestinal disease

(2018) Kara G. Lassen et al.   Autophagy

Metformin reduces TRIB3 expression and restores autophagy flux: an alternative antitumor action

(2018) Ke Li et al.   Autophagy

A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest

(2018) Shohreh Majd et al.   BMC CELL BIOLOGY

Targeting autophagy in cancer

(2018) Angelique V. Onorati et al.   CANCER

miR-570 Inhibits Proliferation, Angiogenesis, and Immune Escape of Hepatocellular Carcinoma

(2018) Yongxin Lin et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Metformin use and incidence cancer risk: evidence for a selective protective effect against liver cancer

(2018) Harvey J. Murff et al.   CANCER CAUSES & CONTROL

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

(2018) Rong Ke et al.   CELL BIOLOGY INTERNATIONAL

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

(2018) Mark Schuiveling et al.   CURRENT DRUG TARGETS

Metformin in cancer

(2018) Ritwika Mallik et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Inhibiting ROS-TFE3-dependent autophagy enhances the therapeutic response to metformin in breast cancer

(2018) Miduo Tan et al.   FREE RADICAL RESEARCH

microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity

(2018) Jarosław Króliczewski et al.   GENE

The miR-3127-5p/p-STAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer

(2018) Dongfang Tang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation

(2018) Cui Zhai et al.   LIFE SCIENCES

Metformin promotes autophagy in Echinococcus granulosus larval stage

(2018) Julia A. Loos et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway

(2018) Yue Guo et al.   NEUROCHEMICAL RESEARCH

Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression

(2018) Ke Li et al.   ONCOGENE

JAK/STAT – Emerging Players in Metabolism

(2018) David W. Dodington et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose

(2018) Can Wu et al.   International Journal of Endocrinology

Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis

(2018) Xiaoli Yang et al.   Cell Death & Disease

Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma

(2018) Xing Bao et al.   Cell Death & Disease

Metformin Improves Neurologic Outcome Via AMP‐Activated Protein Kinase–Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation

(2018) Juan Zhu et al.   Journal of the American Heart Association

Autophagy in Adipose Tissue Physiology and Pathophysiology

(2018) Maroua Ferhat et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin as geroprotector: experimental and clinical evidence

(2018) Veronika Piskovatska et al.   BIOGERONTOLOGY

Hedgehog Signaling Pathway and Autophagy in Cancer

(2018) Xian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin: An Old Drug with New Applications

(2018) Joseph Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis

(2018) Wen-Qi Ma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

AMPK: Potential Therapeutic Target for Ischemic Stroke

(2018) Shuai Jiang et al.   Theranostics

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

(2018) Jin-Liang Chen et al.   EXPERIMENTAL NEUROLOGY

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

(2018) Isaac Tamargo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Roles of Autophagy in Cancer

(2018) Chul Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ER homeostasis and autophagy

(2017) Matthew Smith et al.   Essays in Biochemistry

Dysregulation of autophagy as a common mechanism in lysosomal storage diseases

(2017) Elena Seranova et al.   Essays in Biochemistry

Autophagy in health and disease: focus on the cardiovascular system

(2017) Jeanne Mialet-Perez et al.   Essays in Biochemistry

Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway

(2017) Wen-Dong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1

(2017) Yingli He et al.   JOURNAL OF CELL BIOLOGY

Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin attenuates albumin-induced alterations in renal tubular cells in vitro

(2017) Soumaya Allouch et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin and thyroid disease

(2017) Xianghui Meng et al.   JOURNAL OF ENDOCRINOLOGY

Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives

(2017) Alexander Vaiserman et al.   Journal of Translational Medicine

Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome

(2017) Mirjana Sumarac-Dumanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation

(2017) Logan Slade et al.   MOLECULAR CANCER RESEARCH

Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD-induced obese mice

(2017) Min Li et al.   Molecular Medicine Reports

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death

(2017) Qiuting Yan et al.   MOLECULAR PHARMACOLOGY

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data

(2017) L. Nesti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma

(2017) Jian Wu et al.   ONCOLOGY REPORTS

Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat

(2017) Geetika Garg et al.   REJUVENATION RESEARCH

Inhibition of bioenergetic metabolism by the combination of metformin and 2-deoxyglucose highly decreases viability of feline mammary carcinoma cells

(2017) María Florencia Arbe et al.   RESEARCH IN VETERINARY SCIENCE

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response

(2017) et al.   Viruses-Basel

Metformin: a review of its potential indications

(2017) Yi-Wei Wang et al.   Drug Design Development and Therapy

Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling

(2017) Chi-Fu Chiang et al.   Oncotarget

Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway

(2017) Hsin-Hwa Tsai et al.   Oncotarget

PGC1αActivators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control

(2017) So-Young Lee et al.   Journal of Diabetes Research

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients

(2017) Zhiguang Xiao et al.   NEOPLASIA

Autophagy is activated in the ovarian tissue of polycystic ovary syndrome

(2017) Da Li et al.   REPRODUCTION

Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

(2017) Ming-Yang Chang et al.   Scientific Reports

Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma

(2016) Zhihong Zhuo et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury

(2016) Chen Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aging and Autophagy in the Heart

(2016) Akihiro Shirakabe et al.   CIRCULATION RESEARCH

Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin

(2016) Emilie Bahne et al.   DIABETES OBESITY & METABOLISM

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway

(2016) Sunbin Ling et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

(2016) Sung Min Son et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production

(2016) Ling He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NHX-5, an Endosomal Na+/H+Exchanger, Is Associated with Metformin Action

(2016) Jeongho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

(2016) Ping-yuan Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs

(2016) Min-Jung Park et al.   Translational Research

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo

(2016) Deheng Chen et al.   Cell Death & Disease

Metformin induces degradation of mTOR protein in breast cancer cells

(2016) Mohamed Alalem et al.   Cancer Medicine

The antileukemia effect of metformin in the Philadelphia chromosome-positive leukemia cell line and patient primary leukemia cell

(2015) Rui Shi et al.   ANTI-CANCER DRUGS

Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms

(2015) Wen-Dong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tribbles pseudokinases: novel targets for chemical biology and drug discovery?

(2015) D. M. Foulkes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Endoplasmic Reticulum Stress Response and Mutant Protein Degradation in CHO Cells Accumulating Antithrombin (C95R) in Russell Bodies

(2015) Koji Kimura et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy

(2015) Satoru Kobayashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma

(2015) J.-J. Zhao et al.   CANCER RESEARCH

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucose-deprivation increases thyroid cancer cells sensitivity to metformin

(2015) Athanasios Bikas et al.   ENDOCRINE-RELATED CANCER

The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?

(2015) Charles J Malemud   Future Medicinal Chemistry

Physiological Functions and Regulation of the Na+/H+ Exchanger [NHE1] in Renal Tubule Epithelial Cells

(2015) Patricia G Vallés et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

(2015) S Jagannathan et al.   LEUKEMIA

Metformin synergistically sensitizes FLT3-ITD-positive acute myeloid leukemia to sorafenib by promoting mTOR-mediated apoptosis and autophagy

(2015) Fangfang Wang et al.   LEUKEMIA RESEARCH

Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia

(2015) Alireza Sarkaki et al.   METABOLIC BRAIN DISEASE

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

(2015) Yi-Sheng Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis

(2015) Hee-sun Moon et al.   MOLECULAR CARCINOGENESIS

MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma

(2015) Wei Guo et al.   TUMOR BIOLOGY

CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4

(2015) Diana Aguilar-Morante et al.   Oncotarget

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

(2015) Mohamed A.Y. Abdel Malek et al.   Oncotarget

Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells

(2015) Deok-Bae Park   Diabetes & Metabolism Journal

Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth

(2015) Hua Yang et al.   PLoS One

Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

(2015) Julie Sesen et al.   PLoS One

Selective inhibition of IFNG-induced autophagy byMir155- andMir31-responsive WNT5A and SHH signaling

(2014) Sahana Holla et al.   Autophagy

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The MAPK pathway across different malignancies: A new perspective

(2014) Mauricio Burotto et al.   CANCER

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy

(2014) Yingling Jiang et al.   International Journal of Biological Sciences

Effects of metformin on retinoblastoma growth in vitro and in vivo

(2014) KATARZYNA BRODOWSKA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) β

(2014) Liang Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

New Function of Type I IFN: Induction of Autophagy

(2014) Hana Schmeisser et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Autophagy in the endocrine glands

(2014) Andrea Weckman et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling

(2014) Altaf Mohammed et al.   Translational Oncology

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway

(2014) Yifeng Sun et al.   Scientific Reports

Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

(2013) Hui Sun et al.   Anti-Cancer Agents in Medicinal Chemistry

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The Long and Short of MicroRNA

(2013) Luke A. Yates et al.   CELL

Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells

(2013) Ying Wang et al.   HEPATOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment

(2013) D Lettieri Barbato et al.   Cell Death & Disease

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

(2012) He Huang et al.   Autophagy

AKT/GSK3β-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model

(2012) Zhi-Feng Qi et al.   CNS Neuroscience & Therapeutics

Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

(2012) C. He et al.   DIABETES

Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells

(2012) Farhat V.N. Din et al.   GASTROENTEROLOGY

Metformin impairs the growth of liver kinase B1-intact cervical cancer cells

(2012) Xuxian Xiao et al.   GYNECOLOGIC ONCOLOGY

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

FOXOphagy path to inducing stress resistance and cell survival

(2012) Marco Sandri   NATURE CELL BIOLOGY

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal–lysosomal dysfunction

(2011) Petter Strømme et al.   BRAIN

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

(2011) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications

(2011) C Grimaldi et al.   LEUKEMIA

Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

(2011) J.-H. Cheong et al.   MOLECULAR CANCER THERAPEUTICS

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin in polycystic ovary syndrome

(2010) Evanthia Diamanti-Kandarakis et al.   Annals of the New York Academy of Sciences

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Chemical Synthesis and Structure of the Prokineticin Bv8

(2010) Rodrigo A. V. Morales et al.   CHEMBIOCHEM

Metformin Activates AMP Kinase through Inhibition of AMP Deaminase

(2010) Jiangyong Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes

(2009) Claire Regazzetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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