Metformin‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition

Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer

(2019) Li Li et al.   CANCER LETTERS

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer

(2018) Lifeng Li et al.   CANCER RESEARCH

Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway

(2018) Yu Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms

(2018) João Agostinho Machado-Neto et al.   Cell Death & Disease

Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy

(2018) Ruth Shiloh et al.   Nature Communications

Driven by Mutations: The Predictive Value of Mutation Subtype in EGFR -Mutated Non–Small Cell Lung Cancer

(2017) Emily Castellanos et al.   Journal of Thoracic Oncology

Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer

(2017) Ke Chen et al.   Molecular Cancer

Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer

(2017) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells

(2017) Zheng-Hai Tang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Vorinostat and metformin sensitize EGFR-TKI resistant NSCLC cells via BIM-dependent apoptosis induction

(2017) Hengyi Chen et al.   Oncotarget

Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells

(2017) Yu-Ting Kang et al.   Oncotarget

Combined Inhibitions of Glycolysis and AKT/autophagy Can Overcome Resistance to EGFR-targeted Therapy of Lung Cancer

(2017) Mingtong Ye et al.   Journal of Cancer

mAb MDR1-modified chitosan nanoparticles overcome acquired EGFR-TKI resistance through two potential therapeutic targets modulation of MDR1 and autophagy

(2017) Yan Zheng et al.   JOURNAL OF NANOBIOTECHNOLOGY

The safety and efficacy of osimertinib for the treatment ofEGFRT790M mutation positive non-small-cell lung cancer

(2016) Xin Gao et al.   Expert Review of Anticancer Therapy

Autophagy inhibition facilitates erlotinib cytotoxicity in lung cancer cells through modulation of endoplasmic reticulum stress

(2016) ZHONGLIANG WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Survival of Patients with Stage IV Lung Cancer with Diabetes Treated with Metformin

(2015) Jenny J. Lin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

First-line erlotinib versus gemcitabine/cisplatin in patients with advancedEGFRmutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study

(2015) Y.-L. Wu et al.   ANNALS OF ONCOLOGY

Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer

(2015) Karen L. Reckamp et al.   CANCER

Synergistic effects of metformin in combination with EGFR-TKI in the treatment of patients with advanced non-small cell lung cancer and type 2 diabetes

(2015) Hengyi Chen et al.   CANCER LETTERS

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines

(2015) SHUNTARO MUKAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells

(2015) Mei-Chuan Tang et al.   PLoS One

Metformin and erlotinib synergize to inhibit basal breast cancer

(2015) Ying-Ka Ingar Lau et al.   Oncotarget

Metformin Sensitizes EGFR-TKI-Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

(2014) L. Li et al.   CLINICAL CANCER RESEARCH

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of AMP-activated protein kinase in cross-talk between apoptosis and autophagy in human colon cancer

(2014) X Song et al.   Cell Death & Disease

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

New Targetable Oncogenes in Non–Small-Cell Lung Cancer

(2013) Geoffrey R. Oxnard et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin enhances gefitinib-induced cytotoxicity in human squamous lung cancer cells

(2013) Jen-Chung Ko et al.   LUNG CANCER

Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

(2009) Tetsuya Mitsudomi et al.   LANCET ONCOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY