Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis

Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity In Vivo

(2015) Ramandeep Rattan et al.   NEOPLASIA

Metformin—mode of action and clinical implications for diabetes and cancer

(2014) Ida Pernicova et al.   Nature Reviews Endocrinology

Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling

(2014) Y Feng et al.   Cell Death & Disease

Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma

(2013) Qishan Tang et al.   CANCER LETTERS

ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo

(2013) Jing Xin et al.   CANCER LETTERS

Metformin targets c-MYC oncogene to prevent prostate cancer

(2013) Tunde Akinyeke et al.   CARCINOGENESIS

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy

(2012) Dong Hoon Suh et al.   Annals of the New York Academy of Sciences

Metformin intake is associated with better survival in ovarian cancer

(2012) Sanjeev Kumar et al.   CANCER

Metformin targets ovarian cancer stem cells in vitro and in vivo

(2012) Jessica J. Shank et al.   GYNECOLOGIC ONCOLOGY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

(2012) Arian Emami Riedmaier et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures

(2012) Daniel K Chan et al.   Journal of Ovarian Research

Relevance of the OCT1 transporter to the antineoplastic effect of biguanides

(2011) Eric D. Segal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and cancer therapy

(2011) Paola Maycotte et al.   CANCER BIOLOGY & THERAPY

Autophagy inhibition promotes paclitaxel-induced apoptosis in cancer cells

(2011) Guangmin Xi et al.   CANCER LETTERS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins

(2011) Amber Yasmeen et al.   GYNECOLOGIC ONCOLOGY

Use of metformin and the risk of ovarian cancer: A case–control analysis

(2011) Michael Bodmer et al.   GYNECOLOGIC ONCOLOGY

LY294002 and Metformin Cooperatively Enhance the Inhibition of Growth and the Induction of Apoptosis of Ovarian Cancer Cells

(2011) Cuilan Li et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells

(2011) Y. Zhuang et al.   MOLECULAR CANCER RESEARCH

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity

(2011) Iris L. Romero et al.   OBSTETRICS AND GYNECOLOGY

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner

(2009) R. Rattan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells

(2009) Donglei Liu et al.   MEDICAL ONCOLOGY

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

(2009) Min Ni et al.   PLoS One

Endoplasmic reticulum stress and autophagy as targets for cancer therapy

(2008) Axel H. Schönthal   CANCER LETTERS

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

(2008) Walter H. Gotlieb et al.   GYNECOLOGIC ONCOLOGY