Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response

HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors release of viral particles

(2017) Regina Medvedev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M

(2017) Marianne D. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagy elongation complex (ATG5-12/16L1) positively regulates HCV replication and is required for wild-type membranous web formation

(2017) Ahmed M. Fahmy et al.   Scientific Reports

Selective autophagy gets more selective: Uncoupling of autophagy flux and xenophagy flux inMycobacterium tuberculosis-infected macrophages

(2016) Pallavi Chandra et al.   Autophagy

Suppression of Host Innate Immune Response by Hepatitis C Virus via Induction of Autophagic Degradation of TRAF6

(2016) Stephanie T. Chan et al.   JOURNAL OF VIROLOGY

NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus Polymerase

(2016) Serena Vegna et al.   JOURNAL OF VIROLOGY

Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A

(2016) Nari Kim et al.   Nature Communications

Hepatitis C virus and autophagy

(2015) Linya Wang et al.   BIOLOGICAL CHEMISTRY

MDA5 plays a critical role in interferon response during hepatitis C virus infection

(2015) Xuezhi Cao et al.   JOURNAL OF HEPATOLOGY

Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway

(2015) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

Selective autophagy: Xenophagy

(2015) Kyle A. Bauckman et al.   METHODS

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

TNF-α Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism

(2015) Jiyoung Lee et al.   PLoS Pathogens

HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

(2015) Linya Wang et al.   PLoS Pathogens

Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture

(2015) Ramazan Kurt et al.   PLoS One

Emerging roles of interferon-stimulated genes in the innate immune response to hepatitis C virus infection

(2014) Mun-Teng Wong et al.   Cellular & Molecular Immunology

Autophagy in Antimicrobial Immunity

(2014) Ligia C. Gomes et al.   MOLECULAR CELL

ER stress, autophagy, and RNA viruses

(2014) Jia-Rong Jheng et al.   Frontiers in Microbiology

HCV Infection Selectively Impairs Type I but Not Type III IFN Signaling

(2013) Partha K. Chandra et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

(2013) Ralf Bartenschlager et al.   NATURE REVIEWS MICROBIOLOGY

HCV and Oxidative Stress in the Liver

(2013) Alexander Ivanov et al.   Viruses-Basel

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

(2012) Donna Sir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The p7 protein of the hepatitis C virus induces cell death differently from the influenza A virus viroporin M2

(2012) Jude Juventus Aweya et al.   VIRUS RESEARCH

dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection

(2012) Stéphanie Dabo et al.   Viruses-Basel

Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection

(2011) Pierre-Emmanuel Rautou et al.   AMERICAN JOURNAL OF PATHOLOGY

Differential, Type I Interferon-Mediated Autophagic Trafficking of Hepatitis C Virus Proteins in Mouse Liver

(2011) Mayura M. Desai et al.   GASTROENTEROLOGY

Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates

(2011) Kui Li et al.   HEPATOLOGY

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy

(2011) W.-C. Su et al.   JOURNAL OF VIROLOGY

Dysfunction of Autophagy Participates in Vacuole Formation and Cell Death in Cells Replicating Hepatitis C Virus

(2011) S. Taguwa et al.   JOURNAL OF VIROLOGY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

(2010) Shubham Shrivastava et al.   HEPATOLOGY

Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro

(2010) Po-Yuan Ke et al.   JOURNAL OF CLINICAL INVESTIGATION

Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

(2010) P. Ferraris et al.   JOURNAL OF GENERAL VIROLOGY

Regulation of PKR by HCV IRES RNA: Importance of Domain II and NS5A

(2010) Rebecca Toroney et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection

(2010) Carl Guévin et al.   VIROLOGY

Translational insensitivity to potent activation of PKR by HCV IRES RNA

(2009) Takashi Shimoike et al.   ANTIVIRAL RESEARCH

Knockdown of autophagy-related gene decreases the production of infectious Hepatitis C virus particles

(2009) Isei Tanida et al.   Autophagy

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response

(2008) Donna Sir et al.   HEPATOLOGY

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE