标题
The effects of metformin on autophagy
作者
关键词
Metformin, Autophagy, AMPK, mTOR, Diseases
出版物
BIOMEDICINE & PHARMACOTHERAPY
Volume 137, Issue -, Pages 111286
出版商
Elsevier BV
发表日期
2021-01-30
DOI
10.1016/j.biopha.2021.111286
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Metformin Suppresses LPS-Induced Inflammatory Responses in Macrophage and Ameliorates Allergic Contact Dermatitis in Mice via Autophagy
- (2020) Mengjie Wang et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study
- (2020) Shipra Bhansali et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metformin Activates the AMPK-mTOR Pathway by Modulating lncRNA TUG1 to Induce Autophagy and Inhibit Atherosclerosis
- (2020) Ganhua You et al. Drug Design Development and Therapy
- Metformin inhibits high glucose-induced smooth muscle cell proliferation and migration
- (2020) Dong-Ming Zhou et al. Aging-US
- Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages
- (2020) Beibei Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Metformin attenuates sevoflurane-induced neurocognitive impairment through AMPK-ULK1-dependent autophagy in aged mice
- (2020) Zhu Jinpiao et al. BRAIN RESEARCH BULLETIN
- Benefits of Metformin in Attenuating the Hallmarks of Aging
- (2020) Ameya S. Kulkarni et al. Cell Metabolism
- The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials
- (2020) Mohammad Jalali et al. PHARMACOLOGICAL RESEARCH
- Metformin as Host-Directed Therapy for TB Treatment: Scoping Review
- (2020) Nikita Naicker et al. Frontiers in Microbiology
- Origanum majorana Essential Oil Triggers p38 MAPK-Mediated Protective Autophagy, Apoptosis, and Caspase-Dependent Cleavage of P70S6K in Colorectal Cancer Cells
- (2020) Khawlah Athamneh et al. Biomolecules
- Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway
- (2019) Chao Niu et al. Autophagy
- Biological Functions of Autophagy Genes: A Disease Perspective
- (2019) Beth Levine et al. CELL
- Metformin prevents cell tumorigenesis through autophagy-related cell death
- (2019) Mauro De Santi et al. Scientific Reports
- Differential Effects of Rapamycin and Metformin in Combination with Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
- (2019) Christopher A Wolff et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1
- (2019) Sung-Hyun Hwang et al. CANCER SCIENCE
- Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo
- (2019) Yong-li Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metformin Enhances Autophagy and Provides Cardioprotection in δ-Sarcoglycan Deficiency-Induced Dilated Cardiomyopathy
- (2019) Hiromitsu Kanamori et al. Circulation-Heart Failure
- Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice
- (2019) Chenglai Xia et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase
- (2019) Yun Liu et al. JOURNAL OF VASCULAR RESEARCH
- Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways
- (2019) Yishi Wang et al. LIFE SCIENCES
- Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
- (2019) Qingxue Li et al. Food Science & Nutrition
- Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation
- (2019) Xiao-Wei Zhang et al. Autophagy
- Inhibition of MEK5 suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway
- (2019) Myungjin Jo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Autophagy as a molecular target for cancer treatment
- (2019) Nur Mehpare Kocaturk et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Treatment with metformin and sorafenib alleviates endometrial hyperplasia in polycystic ovary syndrome by promoting apoptosis via synergically regulating autophagy
- (2019) Qian-qing Wang et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Metformin inhibits angiogenesis of endothelial progenitor cells via miR-221-mediated p27 expression and autophagy
- (2019) Hai-Zhen Ni et al. Future Medicinal Chemistry
- Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice
- (2019) Zhu Wang et al. Cell and Bioscience
- Autophagy in Kidney Disease
- (2019) Mary E. Choi Annual Review of Physiology
- Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
- (2019) Björn Neumann et al. Cell Stem Cell
- Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells
- (2019) Ljubica Vucicevic et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Metformin‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition
- (2019) Hengyi Chen et al. Clinical Respiratory Journal
- Metformin Suppresses Self-Renewal Ability and Tumorigenicity of Osteosarcoma Stem Cells via Reactive Oxygen Species-Mediated Apoptosis and Autophagy
- (2019) Bin Zhao et al. Oxidative Medicine and Cellular Longevity
- Curtailing PCOS
- (2019) Selma Feldman Witchel et al. PEDIATRIC RESEARCH
- Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis
- (2019) Jiang Xu et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway
- (2019) Ruijie Sun et al. Cancer Medicine
- Does Metformin Modulate Endoplasmic Reticulum Stress and Autophagy in Type 2 Diabetic Peripheral Blood Mononuclear Cells?
- (2018) Noelia Diaz-Morales et al. ANTIOXIDANTS & REDOX SIGNALING
- Mechanisms and function of autophagy in intestinal disease
- (2018) Kara G. Lassen et al. Autophagy
- Metformin reduces TRIB3 expression and restores autophagy flux: an alternative antitumor action
- (2018) Ke Li et al. Autophagy
- A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest
- (2018) Shohreh Majd et al. BMC CELL BIOLOGY
- Targeting autophagy in cancer
- (2018) Angelique V. Onorati et al. CANCER
- miR-570 Inhibits Proliferation, Angiogenesis, and Immune Escape of Hepatocellular Carcinoma
- (2018) Yongxin Lin et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- Metformin use and incidence cancer risk: evidence for a selective protective effect against liver cancer
- (2018) Harvey J. Murff et al. CANCER CAUSES & CONTROL
- Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
- (2018) Rong Ke et al. CELL BIOLOGY INTERNATIONAL
- Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?
- (2018) Mark Schuiveling et al. CURRENT DRUG TARGETS
- Metformin in cancer
- (2018) Ritwika Mallik et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Inhibiting ROS-TFE3-dependent autophagy enhances the therapeutic response to metformin in breast cancer
- (2018) Miduo Tan et al. FREE RADICAL RESEARCH
- microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity
- (2018) Jarosław Króliczewski et al. GENE
- The miR-3127-5p/p-STAT3 axis up-regulates PD-L1 inducing chemoresistance in non-small-cell lung cancer
- (2018) Dongfang Tang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways
- (2018) Yan Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation
- (2018) Cui Zhai et al. LIFE SCIENCES
- Metformin promotes autophagy in Echinococcus granulosus larval stage
- (2018) Julia A. Loos et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway
- (2018) Yue Guo et al. NEUROCHEMICAL RESEARCH
- Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression
- (2018) Ke Li et al. ONCOGENE
- JAK/STAT – Emerging Players in Metabolism
- (2018) David W. Dodington et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metformin Regulating miR-34a Pathway to Inhibit Egr1 in Rat Mesangial Cells Cultured with High Glucose
- (2018) Can Wu et al. International Journal of Endocrinology
- Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis
- (2018) Xiaoli Yang et al. Cell Death & Disease
- Inhibition of LCMR1 and ATG12 by demethylation-activated miR-570-3p is involved in the anti-metastasis effects of metformin on human osteosarcoma
- (2018) Xing Bao et al. Cell Death & Disease
- Metformin Improves Neurologic Outcome Via AMP‐Activated Protein Kinase–Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation
- (2018) Juan Zhu et al. Journal of the American Heart Association
- Autophagy in Adipose Tissue Physiology and Pathophysiology
- (2018) Maroua Ferhat et al. ANTIOXIDANTS & REDOX SIGNALING
- Metformin as geroprotector: experimental and clinical evidence
- (2018) Veronika Piskovatska et al. BIOGERONTOLOGY
- Hedgehog Signaling Pathway and Autophagy in Cancer
- (2018) Xian Zeng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metformin: An Old Drug with New Applications
- (2018) Joseph Zhou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
- (2018) Wen-Qi Ma et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- AMPK: Potential Therapeutic Target for Ischemic Stroke
- (2018) Shuai Jiang et al. Theranostics
- Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance
- (2018) Jin-Liang Chen et al. EXPERIMENTAL NEUROLOGY
- AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy
- (2018) Isaac Tamargo-Gómez et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Roles of Autophagy in Cancer
- (2018) Chul Yun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ER homeostasis and autophagy
- (2017) Matthew Smith et al. Essays in Biochemistry
- Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
- (2017) Elena Seranova et al. Essays in Biochemistry
- Autophagy in health and disease: focus on the cardiovascular system
- (2017) Jeanne Mialet-Perez et al. Essays in Biochemistry
- Metformin inhibits endothelial progenitor cell migration by decreasing matrix metalloproteinases, MMP-2 and MMP-9, via the AMPK/mTOR/autophagy pathway
- (2017) Wen-Dong Li et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1
- (2017) Yingli He et al. JOURNAL OF CELL BIOLOGY
- Crosstalk of ER stress-mediated autophagy and ER-phagy: Involvement of UPR and the core autophagy machinery
- (2017) Shuling Song et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Metformin attenuates albumin-induced alterations in renal tubular cells in vitro
- (2017) Soumaya Allouch et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Metformin and thyroid disease
- (2017) Xianghui Meng et al. JOURNAL OF ENDOCRINOLOGY
- Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives
- (2017) Alexander Vaiserman et al. Journal of Translational Medicine
- Downregulation of autophagy gene expression in endometria from women with polycystic ovary syndrome
- (2017) Mirjana Sumarac-Dumanovic et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation
- (2017) Logan Slade et al. MOLECULAR CANCER RESEARCH
- Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD-induced obese mice
- (2017) Min Li et al. Molecular Medicine Reports
- Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death
- (2017) Qiuting Yan et al. MOLECULAR PHARMACOLOGY
- Autophagy in the liver: functions in health and disease
- (2017) Takashi Ueno et al. Nature Reviews Gastroenterology & Hepatology
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data
- (2017) L. Nesti et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- MACC1 induces autophagy to regulate proliferation, apoptosis, migration and invasion of squamous cell carcinoma
- (2017) Jian Wu et al. ONCOLOGY REPORTS
- Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat
- (2017) Geetika Garg et al. REJUVENATION RESEARCH
- Inhibition of bioenergetic metabolism by the combination of metformin and 2-deoxyglucose highly decreases viability of feline mammary carcinoma cells
- (2017) María Florencia Arbe et al. RESEARCH IN VETERINARY SCIENCE
- Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease
- (2017) Patrick A. Eyers et al. TRENDS IN CELL BIOLOGY
- Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response
- (2017) et al. Viruses-Basel
- Metformin: a review of its potential indications
- (2017) Yi-Wei Wang et al. Drug Design Development and Therapy
- Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling
- (2017) Chi-Fu Chiang et al. Oncotarget
- Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway
- (2017) Hsin-Hwa Tsai et al. Oncotarget
- PGC1αActivators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control
- (2017) So-Young Lee et al. Journal of Diabetes Research
- Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients
- (2017) Zhiguang Xiao et al. NEOPLASIA
- Autophagy is activated in the ovarian tissue of polycystic ovary syndrome
- (2017) Da Li et al. REPRODUCTION
- Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency
- (2017) Ming-Yang Chang et al. Scientific Reports
- Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma
- (2016) Zhihong Zhuo et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury
- (2016) Chen Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Aging and Autophagy in the Heart
- (2016) Akihiro Shirakabe et al. CIRCULATION RESEARCH
- Involvement of glucagon-like peptide-1 in the glucose-lowering effect of metformin
- (2016) Emilie Bahne et al. DIABETES OBESITY & METABOLISM
- Metformin and the gastrointestinal tract
- (2016) Laura J. McCreight et al. DIABETOLOGIA
- Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway
- (2016) Sunbin Ling et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation
- (2016) Sung Min Son et al. JOURNAL OF ALZHEIMERS DISEASE
- Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production
- (2016) Ling He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NHX-5, an Endosomal Na+/H+Exchanger, Is Associated with Metformin Action
- (2016) Jeongho Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TFEB at a glance
- (2016) Gennaro Napolitano et al. JOURNAL OF CELL SCIENCE
- Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome
- (2016) Ping-yuan Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs
- (2016) Min-Jung Park et al. Translational Research
- Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
- (2016) Deheng Chen et al. Cell Death & Disease
- Metformin induces degradation of mTOR protein in breast cancer cells
- (2016) Mohamed Alalem et al. Cancer Medicine
- The antileukemia effect of metformin in the Philadelphia chromosome-positive leukemia cell line and patient primary leukemia cell
- (2015) Rui Shi et al. ANTI-CANCER DRUGS
- Metformin regulates differentiation of bone marrow-derived endothelial progenitor cells via multiple mechanisms
- (2015) Wen-Dong Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
- (2015) D. M. Foulkes et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Endoplasmic Reticulum Stress Response and Mutant Protein Degradation in CHO Cells Accumulating Antithrombin (C95R) in Russell Bodies
- (2015) Koji Kimura et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Choose Delicately and Reuse Adequately: The Newly Revealed Process of Autophagy
- (2015) Satoru Kobayashi BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma
- (2015) J.-J. Zhao et al. CANCER RESEARCH
- The endoplasmic reticulum: structure, function and response to cellular signaling
- (2015) Dianne S. Schwarz et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Glucose-deprivation increases thyroid cancer cells sensitivity to metformin
- (2015) Athanasios Bikas et al. ENDOCRINE-RELATED CANCER
- The PI3K/Akt/PTEN/mTOR pathway: a fruitful target for inducing cell death in rheumatoid arthritis?
- (2015) Charles J Malemud Future Medicinal Chemistry
- Physiological Functions and Regulation of the Na+/H+ Exchanger [NHE1] in Renal Tubule Epithelial Cells
- (2015) Patricia G Vallés et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib
- (2015) S Jagannathan et al. LEUKEMIA
- Metformin synergistically sensitizes FLT3-ITD-positive acute myeloid leukemia to sorafenib by promoting mTOR-mediated apoptosis and autophagy
- (2015) Fangfang Wang et al. LEUKEMIA RESEARCH
- Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia
- (2015) Alireza Sarkaki et al. METABOLIC BRAIN DISEASE
- Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation
- (2015) Yi-Sheng Hou et al. MOLECULAR AND CELLULAR BIOLOGY
- Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2α) pathway protect ovarian cancer cells from metformin-induced apoptosis
- (2015) Hee-sun Moon et al. MOLECULAR CARCINOGENESIS
- MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma
- (2015) Wei Guo et al. TUMOR BIOLOGY
- CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4
- (2015) Diana Aguilar-Morante et al. Oncotarget
- Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma
- (2015) Mohamed A.Y. Abdel Malek et al. Oncotarget
- Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells
- (2015) Deok-Bae Park Diabetes & Metabolism Journal
- Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth
- (2015) Hua Yang et al. PLoS One
- Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response
- (2015) Julie Sesen et al. PLoS One
- Selective inhibition of IFNG-induced autophagy byMir155- andMir31-responsive WNT5A and SHH signaling
- (2014) Sahana Holla et al. Autophagy
- Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
- (2014) Young Mi Song et al. Autophagy
- Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy
- (2014) Teng Jiang et al. BRITISH JOURNAL OF PHARMACOLOGY
- The MAPK pathway across different malignancies: A new perspective
- (2014) Mauricio Burotto et al. CANCER
- Metformin: From Mechanisms of Action to Therapies
- (2014) Marc Foretz et al. Cell Metabolism
- Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy
- (2014) Yingling Jiang et al. International Journal of Biological Sciences
- Effects of metformin on retinoblastoma growth in vitro and in vivo
- (2014) KATARZYNA BRODOWSKA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) β
- (2014) Liang Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis
- (2014) Sayaka Inokuchi-Shimizu et al. JOURNAL OF CLINICAL INVESTIGATION
- New Function of Type I IFN: Induction of Autophagy
- (2014) Hana Schmeisser et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Autophagy in the endocrine glands
- (2014) Andrea Weckman et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury
- (2014) Jianzhong Li et al. KIDNEY INTERNATIONAL
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- (2014) J. A. Martina et al. Science Signaling
- Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling
- (2014) Altaf Mohammed et al. Translational Oncology
- Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
- (2014) Y Feng et al. Cell Death & Disease
- Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway
- (2014) Yifeng Sun et al. Scientific Reports
- Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents
- (2013) Hui Sun et al. Anti-Cancer Agents in Medicinal Chemistry
- An Overview of Autophagy: Morphology, Mechanism, and Regulation
- (2013) Katherine R. Parzych et al. ANTIOXIDANTS & REDOX SIGNALING
- The Long and Short of MicroRNA
- (2013) Luke A. Yates et al. CELL
- Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
- (2013) Ying Wang et al. HEPATOLOGY
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- (2013) Pengda Liu et al. NATURE CELL BIOLOGY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment
- (2013) D Lettieri Barbato et al. Cell Death & Disease
- Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy
- (2012) He Huang et al. Autophagy
- AKT/GSK3β-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model
- (2012) Zhi-Feng Qi et al. CNS Neuroscience & Therapeutics
- Dissociation of Bcl-2-Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
- (2012) C. He et al. DIABETES
- Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells
- (2012) Farhat V.N. Din et al. GASTROENTEROLOGY
- Metformin impairs the growth of liver kinase B1-intact cervical cancer cells
- (2012) Xuxian Xiao et al. GYNECOLOGIC ONCOLOGY
- Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity
- (2012) Shensi Shen et al. MOLECULAR CELL
- FOXOphagy path to inducing stress resistance and cell survival
- (2012) Marco Sandri NATURE CELL BIOLOGY
- Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
- (2012) W-Y Shi et al. Cell Death & Disease
- X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal–lysosomal dysfunction
- (2011) Petter Strømme et al. BRAIN
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Autophagy: Renovation of Cells and Tissues
- (2011) Noboru Mizushima et al. CELL
- Cellular and molecular mechanisms of metformin: an overview
- (2011) Benoit Viollet et al. CLINICAL SCIENCE
- Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems
- (2011) Jeffrey L Brodsky et al. CURRENT OPINION IN CELL BIOLOGY
- Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
- (2011) Z. Xie et al. DIABETES
- AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
- (2011) C Grimaldi et al. LEUKEMIA
- Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models
- (2011) J.-H. Cheong et al. MOLECULAR CANCER THERAPEUTICS
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
- (2011) T Tomic et al. Cell Death & Disease
- AMPK and SIRT1: a long-standing partnership?
- (2010) Neil B. Ruderman et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Metformin in polycystic ovary syndrome
- (2010) Evanthia Diamanti-Kandarakis et al. Annals of the New York Academy of Sciences
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Chemical Synthesis and Structure of the Prokineticin Bv8
- (2010) Rodrigo A. V. Morales et al. CHEMBIOCHEM
- Metformin Activates AMP Kinase through Inhibition of AMP Deaminase
- (2010) Jiangyong Ouyang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
- (2010) P. Horak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin Induces REDD1 Expression through Hypoxia-inducible Factor 1 Activation in Adipocytes
- (2009) Claire Regazzetti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival
- (2008) Seoung Hoon Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNAs 221 and 222 Bypass Quiescence and Compromise Cell Survival
- (2008) R. Medina et al. CANCER RESEARCH
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started