Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration

Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy

(2020) Jingyi Zhu et al.   ACS Nano

Fluorinated Chitosan To Enhance Transmucosal Delivery of Sonosensitizer-Conjugated Catalase for Sonodynamic Bladder Cancer Treatment Post-intravesical Instillation

(2020) Guangzhi Li et al.   ACS Nano

Near-Infrared Laser-Triggered In Situ Dimorphic Transformation of BF2-Azadipyrromethene Nanoaggregates for Enhanced Solid Tumor Penetration

(2020) Yuanfang Chen et al.   ACS Nano

A Size‐Changeable Collagenase‐Modified Nanoscavenger for Increasing Penetration and Retention of Nanomedicine in Deep Tumor Tissue

(2020) Funeng Xu et al.   ADVANCED MATERIALS

Bioinspired Artificial Tobacco Mosaic Virus with Combined Oncolytic Properties to Completely Destroy Multidrug‐Resistant Cancer

(2020) Huayu Wu et al.   ADVANCED MATERIALS

Metformin-Induced Stromal Depletion to Enhance the Penetration of Gemcitabine-Loaded Magnetic Nanoparticles for Pancreatic Cancer Targeted Therapy

(2020) Haijie Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Surface Modification of Polymeric Biomaterials for Biomedical Applications

(2020) Wei Sun et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Enzyme-Triggered Transcytosis of Dendrimer–Drug Conjugate for Deep Penetration into Pancreatic Tumors

(2020) Guowei Wang et al.   ACS Nano

Zwitterionic Polysulfamide Drug Nanogels with Microwave Augmented Tumor Accumulation and On-Demand Drug Release for Enhanced Cancer Therapy

(2020) Shaojun Peng et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor‐exocytosed exosome/AIEgen hybrid nano‐vesicles facilitate efficient tumor penetration and photodynamic therapy

(2020) Daoming Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bacteria as Nanoparticles Carrier for Enhancing Penetration in a Tumoral Matrix Model

(2020) Víctor M. Moreno et al.   Advanced Materials Interfaces

Parallels of Resistance between Angiogenesis and Lymphangiogenesis Inhibition in Cancer Therapy

(2020) Dennis Jones   Cells

Nitric oxide-induced stromal depletion for improved nanoparticle penetration in pancreatic cancer treatment

(2020) Xiaohui Chen et al.   BIOMATERIALS

Mussel‐Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment

(2020) Wenyan Wang et al.   MACROMOLECULAR BIOSCIENCE

Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect

(2019) Hangyi Wu et al.   Acta Pharmaceutica Sinica B

pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy

(2019) Nansha Gao et al.   Frontiers in Pharmacology

Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion

(2019) Xiao Dong et al.   NANO LETTERS

Drug delivery systems targeting tumor-associated fibroblasts for cancer immunotherapy

(2019) Mengrui Liu et al.   CANCER LETTERS

Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells

(2019) Yuxuan Miao et al.   CELL

Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration

(2019) Mengxue Zhou et al.   NANO LETTERS

The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency

(2019) Qingle Liang et al.   Nature Biomedical Engineering

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

(2019) Jungwook Paek et al.   ACS Nano

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

(2019) Wei Cheng et al.   ACS Nano

Deep Tumor Penetration of Drug-Loaded Nanoparticles by Click Reaction-Assisted Immune Cell Targeting Strategy

(2019) Soo Hong Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

(2019) Guojun Chen et al.   Nature Nanotechnology

Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

(2019) Zheng Wang et al.   Advanced Science

Charge-convertible polymers for improved tumor targeting and enhanced therapy

(2019) Yi Li et al.   BIOMATERIALS

NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy

(2019) Weiwei Cao et al.   CHEMICAL ENGINEERING JOURNAL

NIR light-induced tumor phototherapy using ICG delivery system based on platelet-membrane-camouflaged hollow bismuth selenide nanoparticles

(2019) Kaili Ding et al.   CHINESE CHEMICAL LETTERS

Transcytosis of Nanomedicine for Tumor Penetration

(2019) Yan Liu et al.   NANO LETTERS

Cancer-Cell-Membrane-Coated Nanoparticles with a Yolk–Shell Structure Augment Cancer Chemotherapy

(2019) Di Nie et al.   NANO LETTERS

Tailored multifunctional micellar brushes via crystallization-driven growth from a surface

(2019) Jiandong Cai et al.   SCIENCE

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

(2019) Hong-Wei An et al.   Nature Communications

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Use of Oppositely Polarized External Magnets To Improve the Accumulation and Penetration of Magnetic Nanocarriers into Solid Tumors

(2019) Jessica F. Liu et al.   ACS Nano

Radiosensitive core/satellite ternary heteronanostructure for multimodal imaging-guided synergistic cancer radiotherapy

(2019) Hongxing Liu et al.   BIOMATERIALS

Passion fruit-like exosome-PMA/Au-BSA@Ce6 nanovehicles for real-time fluorescence imaging and enhanced targeted photodynamic therapy with deep penetration and superior retention behavior in tumor

(2019) Shaojun Pan et al.   BIOMATERIALS

Emerging 2D material-based nanocarrier for cancer therapy beyond graphene

(2019) Yingwei Wang et al.   COORDINATION CHEMISTRY REVIEWS

Engineered nanomedicines with enhanced tumor penetration

(2019) Jianxun Ding et al.   Nano Today

Remote Control of Mechanical Forces via Mitochondrial‐Targeted Magnetic Nanospinners for Efficient Cancer Treatment

(2019) Mengwei Chen et al.   Small

Engineered Cell‐Derived Microparticles Bi 2 Se 3 /DOX@MPs for Imaging Guided Synergistic Photothermal/Low‐Dose Chemotherapy of Cancer

(2019) Dongdong Wang et al.   Advanced Science

Coadministration of iRGD with Multistage Responsive Nanoparticles Enhanced Tumor Targeting and Penetration Abilities for Breast Cancer Therapy

(2018) Chuan Hu et al.   ACS Applied Materials & Interfaces

Size/Charge Changeable Acidity-Responsive Micelleplex for Photodynamic-Improved PD-L1 Immunotherapy with Enhanced Tumor Penetration

(2018) Liangliang Dai et al.   ADVANCED FUNCTIONAL MATERIALS

Virion-Like Membrane-Breaking Nanoparticles with Tumor-Activated Cell-and-Tissue Dual-Penetration Conquer Impermeable Cancer

(2018) Xiao Zhang et al.   ADVANCED MATERIALS

Hybrid pH-sensitive nanogels surface-functionalized with collagenase for enhanced tumor penetration

(2018) Xin Wang et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

(2018) Bu-Wei Huang et al.   JOURNAL OF CONTROLLED RELEASE

Junction opener protein increases nanoparticle accumulation in solid tumors

(2018) Christine E. Wang et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular matrix in lung development, homeostasis and disease

(2018) Yong Zhou et al.   MATRIX BIOLOGY

Deep Tumor Penetrating Bioparticulates Inspired Burst Intracellular Drug Release for Precision Chemo-Phototherapy

(2018) Ruoning Wang et al.   Small

Dynamically PEGylated and Borate-Coordination-Polymer-Coated Polydopamine Nanoparticles for Synergetic Tumor-Targeted, Chemo-Photothermal Combination Therapy

(2018) Shucheng Liu et al.   Small

Strategies to improve tumor penetration of nanomedicines through nanoparticle design

(2018) Ya-Ru Zhang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Enzyme-sensitive cytotoxic peptide–dendrimer conjugates enhance cell apoptosis and deep tumor penetration

(2018) Fu-Hua Liu et al.   Biomaterials Science

Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy

(2018) Xi He et al.   Advanced Science

Peptide Mediated In Vivo Tumor Targeting of Nanoparticles through Optimization in Single and Multilayer In Vitro Cell Models

(2018) Celina Yang et al.   Cancers

Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

(2018) Zhiwen Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

One-Step Assembly of a Biomimetic Biopolymer Coating for Particle Surface Engineering

(2018) Ruirui Liu et al.   ADVANCED MATERIALS

A size switchable nanoplatform for targeting the tumor microenvironment and deep tumor penetration

(2018) Xingli Cun et al.   Nanoscale

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Dual Role of Magnetic Nanoparticles as Intracellular Hotspots and Extracellular Matrix Disruptors Triggered by Magnetic Hyperthermia in 3D Cell Culture Models

(2018) Lilianne Beola et al.   ACS Applied Materials & Interfaces

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement

(2018) Ruyi Zhou et al.   BIOMATERIALS

Effects of surface modifications on the physicochemical properties of iron oxide nanoparticles and their performance as anticancer drug carriers

(2018) Lingling Guo et al.   CHINESE CHEMICAL LETTERS

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration

(2018) Shoupeng Cao et al.   ACS Macro Letters

Functional Nanoparticles for Tumor Penetration of Therapeutics

(2018) Yu-Lin Su et al.   Pharmaceutics

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy

(2017) Xinyu He et al.   NANO LETTERS

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

(2017) Hirotaka Ejima et al.   Nano Today

NaYbF4nanoparticles as near infrared light excited inorganic photosensitizers for deep penetration in photodynamic therapy

(2017) J. Y. Zhang et al.   Nanoscale

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Nanoparticle-based hyperthermia, a local treatment modulating the tumor extracellular matrix

(2017) Jelena Kolosnjaj-Tabi et al.   PHARMACOLOGICAL RESEARCH

Protein nanocages that penetrate airway mucus and tumor tissue

(2017) Xinglu Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

(2017) Miles A. Miller et al.   Science Translational Medicine

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

(2017) Joseph L. Regan et al.   Cell Reports

Hydrogen Sulfide Triggered Charge-Reversal Micelles for Cancer-Targeted Drug Delivery and Imaging

(2016) Haitao Zhang et al.   ACS Applied Materials & Interfaces

Thermally Induced Charge Reversal of Layer-by-Layer Assembled Single-Component Polymer Films

(2016) Joseph J. Richardson et al.   ACS Applied Materials & Interfaces

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

(2016) Tingting Lin et al.   ACS Nano

The Penetrated Delivery of Drug and Energy to Tumors by Lipo-Graphene Nanosponges for Photolytic Therapy

(2016) Yu-Lin Su et al.   ACS Nano

In vitro cancer cell–ECM interactions inform in vivo cancer treatment

(2016) Andrew W. Holle et al.   ADVANCED DRUG DELIVERY REVIEWS

The extracellular matrix in breast cancer

(2016) Jacob Insua-Rodríguez et al.   ADVANCED DRUG DELIVERY REVIEWS

Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization

(2016) Sheng Wang et al.   ADVANCED MATERIALS

Development of a multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment

(2016) Xu Song et al.   BIOMATERIALS

Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition

(2016) Zu-Qi Zuo et al.   BIOMATERIALS

Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols

(2016) Karolin Froehlich et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

(2016) Ouajdi Felfoul et al.   Nature Nanotechnology

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Elasticity of Nanoparticles Influences Their Blood Circulation, Phagocytosis, Endocytosis, and Targeting

(2015) Aaron C. Anselmo et al.   ACS Nano

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

(2015) Jinqiang Wang et al.   ACS Nano

pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

(2015) Haijun Yu et al.   ADVANCED FUNCTIONAL MATERIALS

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

(2015) Xin Liu et al.   ADVANCED MATERIALS

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

(2015) Wen-Chia Huang et al.   BIOMATERIALS

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

(2015) Sijumon Kunjachan et al.   NANO LETTERS

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy

(2015) A Borah et al.   Oncogenesis

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

Engineering Multifunctional Capsules through the Assembly of Metal-Phenolic Networks

(2014) Junling Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

Nanotechnology in Radiation Oncology

(2014) Andrew Z. Wang et al.   JOURNAL OF CLINICAL ONCOLOGY

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

A multilayered cell culture model for transport study in solid tumors: Evaluation of tissue penetration of polyethyleneimine based cationic micelles

(2014) Seiji Miura et al.   Nano Today

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Photoswitchable nanoparticles for in vivo cancer chemotherapy

(2013) R. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface modification of inorganic nanoparticles for development of organic–inorganic nanocomposites—A review

(2013) Sarita Kango et al.   PROGRESS IN POLYMER SCIENCE

Polyethyleneimine/DNA polyplexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene delivery

(2012) Yiyan He et al.   BIOMATERIALS

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Cell-penetrating peptides: classes, origin, and current landscape

(2012) Francesca Milletti   DRUG DISCOVERY TODAY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

(2012) Rong Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microenvironment and Radiation Therapy

(2012) Michio Yoshimura et al.   Biomed Research International

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

(2010) Ivo J. Huijbers et al.   PLoS One

Selective targeting of radiation-resistant tumor-initiating cells

(2010) Mei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble Polymer Carriers for the Treatment of Cancer: The Importance of Molecular Architecture

(2009) Megan E. Fox et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Noninvasive Monitoring of the Fate of111In-Labeled Block Copolymer Micelles by High Resolution and High Sensitivity MicroSPECT/CT Imaging

(2009) Bryan Hoang et al.   MOLECULAR PHARMACEUTICS