Review
Biology
Manon Penco-Campillo, Gilles Pages, Sonia Martial
Summary: The therapeutic strategy against medulloblastoma (MB) focuses on accurate diagnosis, post-surgery monitoring, treatment adaptation, and effective therapies for recurrence. Current treatments for MB are severe and result in disabilities. MB recurrence and metastasis are usually fatal, and understanding the key players in this process could help eliminate fatal outcomes. The goal is to reduce treatment intensity and limit disabling effects while offering effective treatments.
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Leonel Pekarek, Diego Torres-Carranza, Oscar Fraile-Martinez, Cielo Garcia-Montero, Tatiana Pekarek, Miguel A. Saez, Francisco Rueda-Correa, Carolina Pimentel-Martinez, Luis G. Guijarro, Raul Diaz-Pedrero, Melchor Alvarez-Mon, Miguel A. Ortega
Summary: Recent studies have shown the importance of epigenetic markers in the development of various malignant tumors, and their role in understanding metastasis and tumor progression in cancer patients. Among these markers, microRNAs are non-coding RNAs that regulate gene expression and play a crucial role in different oncogenic pathways. The overexpression or downregulation of microRNAs is associated with complex interactions with multiple genes, resulting in increased cell proliferation, tumor invasion, and interaction with various driver markers. However, there is currently a lack of diagnostic kits for the initial diagnosis and assessment of cancer recurrence, despite the usefulness of combining different microRNAs for diagnostic and prognostic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Masataka Majima, Kanako Hosono, Yoshiya Ito, Hideki Amano, Yoshinao Nagashima, Yasuhiro Matsuda, Shin-ichi Watanabe, Hironobu Nishimura
Summary: Thromboxane (TX) and prostaglandins, metabolites of arachidonic acid, have various actions through specific receptors. Angiogenesis and lymphangiogenesis, the formation of new blood vessels and lymphatic vessels, respectively, play critical roles in pathological conditions. Accumulating evidence suggests that TX induces the production of proangiogenic and prolymphangiogenic factors, promoting angiogenesis and lymphangiogenesis under disease conditions. This review discusses the emerging importance of TX as a therapeutic target in regulating angiogenesis and lymphangiogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Dermatology
J. Welzel, S. Schuh, N. De Carvalho, L. Themstrup, M. Ulrich, G. B. E. Jemec, J. Holmes, G. Pellacani
Summary: In malignant melanomas, the density of blood vessels is increased, and irregular vascular patterns are more common, especially in high stages and metastatic melanomas.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna, Vikas Jain
Summary: This article discusses the role of Nrf2 in the development of drug resistance, angiogenesis, cancer stem cell generation, and metastasis in breast cancer. Therapeutic strategies utilizing Nrf2 signaling cascades are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Shuang Li, Limin Chen
Summary: Exosomes are extracellular vesicles that play important roles in cell-to-cell communication and can be stably present in various body fluids. They have a unique double-layer saclike structure and reflect the characteristics of their host cells. Exosomes derived from hepatocellular carcinoma cells show heterogeneity in their cargo. Additionally, exosomes are capable of efficiently delivering cargoes to target cells, which significantly impact HCC progression, including tumor occurrence, development, metastasis, immune regulation, and drug resistance. Previous studies have demonstrated wide applications of exosomes in the diagnosis and treatment of HCC. This review discusses recent findings on the significant roles of exosomes in HCC, focusing on their effects and underlying mechanisms in regulating HCC progression and their potential clinical value as biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tomonori Sasahira, Miyako Kurihara-Shimomura, Hiroyuki Shimomura, Tadaaki Kirita
Summary: The gene expression and secretion levels of SERPINE2 were found to be higher in OSCC than in normal oral mucosa. Immunohistochemical analysis revealed that SERPINE2 expression was correlated with depth of invasion, nodal metastasis, microvessel density, and lymphovessel density. Both univariate and multivariate analyses indicated that SERPINE2 expression level was an independent poor prognostic factor for OSCC. In vitro studies showed that SERPINE2 promotes angiogenesis and lymphangiogenesis.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Laura Dupont, Loic Joannes, Florent Morfoisse, Silvia Blacher, Christine Monseur, Christophe F. Deroanne, Agnes Noel, Alain C. M. A. Colige
Summary: The study demonstrates that ADAMTS2 and ADAMTS14 are as efficient as ADAMTS3 in activating pro-VEGFC and play a crucial role in maintaining the homeostasis of the lymphatic vasculature in adulthood.
Review
Nutrition & Dietetics
Seung-Hyeok Park, Minsun Kim, Somi Lee, Woojin Jung, Bonglee Kim
Summary: Cervical cancer is the fourth most common cancer among women worldwide, and natural products play an important role in its treatment, with various mechanisms. Research has found that multiple natural products have inhibitory effects against cervical cancer, with some demonstrating significant multi-effects.
Article
Cell Biology
Aurore Dumond, Christopher Montemagno, Valerie Vial, Renaud Grepin, Gilles Pages
Summary: The study developed specific mouse monoclonal antibodies targeting VEGFC for the treatment of mccRCC, showing potential in inhibiting the growth of metastatic clear cell renal cell carcinoma.
Article
Oncology
Matteo Tantari, Stefano Bogliolo, Matteo Morotti, Vincent Balaya, Florent Bouttitie, Annie Buenerd, Laurent Magaud, Fabrice Lecuru, Benedetta Guani, Patrice Mathevet
Summary: In early-stage cervical cancer, lymphatic spread does not require the proliferation of new lymphatic endothelial cells, highlighting the importance of pre-existing peritumoral lymphatic vessels in the metastatic process. None of the markers of lymphangiogenesis and proliferation evaluated were predictive of pelvic lymph node metastasis or tumor recurrence.
Review
Nutrition & Dietetics
Ahyeon Kim, Jiwon Ha, Jeongeun Kim, Yongmin Cho, Jimyung Ahn, Chunhoo Cheon, Sung-Hoon Kim, Seong-Gyu Ko, Bonglee Kim
Summary: Natural products have potential effects in treating pancreatic cancer, particularly through inducing cell apoptosis. Plant extracts are the main focus in the research, while some natural products exhibit multifunctional properties.
Article
Biochemistry & Molecular Biology
Xinzhao Wang, Zhaoyun Liu, Jujie Sun, Xiang Song, Mengxue Bian, Fukai Wang, Feng Yan, Zhiyong Yu
Summary: Nox4 is a factor that promotes lymphangiogenesis, potentially by attracting breast cancer cells to enter lymphatic vessels and distant organs via the ROS/ERK/CCL21 pathway. Inhibition of Nox4 can reduce tumor lymphangiogenesis and metastasis.
Review
Oncology
Manuel Jesus Perez-Baena, Francisco Josue Cordero-Perez, Jesus Perez-Losada, Marina Holgado-Madruga
Summary: GAB1 is a pleckstrin homology domain-containing protein that plays a crucial role in cellular transformation and cancer progression, activating various signaling pathways and modulating resistance to anticancer therapies. Its deficiency leads to developmental abnormalities, while its dysregulation is associated with worse prognosis in multiple cancer types. Understanding the mechanisms of GAB1 in cancer could provide insights for future anticancer strategies.
Review
Pathology
Joshua N. Gustine, Dennis Jones
Summary: The rapid spread of COVID-19 has led to an unprecedented global public health crisis with recent studies suggesting that the hyperinflammatory syndrome induced by SARS-CoV-2 is a contributing factor to disease severity and mortality. Pathophysiological research shows that the hyperinflammatory syndrome in severe COVID-19 results from a dysregulated innate immune response. Current potential therapeutic approaches are being investigated to modulate the immune response and mitigate lung injury in severe COVID-19.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Alexander M. Saeboe, Alexey Y. Nikiforov, Reyhaneh Toufanian, Joshua C. Kays, Margaret Chern, J. Paolo Casas, Keyi Han, Andrei Piryatinski, Dennis Jones, Allison M. Dennis
Summary: This report showcases the reddest emitting indium phosphide quantum dots to date, demonstrating tunable near-infrared photoluminescence and PL multiplexing in the first optical tissue window while avoiding toxic constituents. By utilizing an inverted QD heterostructure, the synthesis overcomes the growth bottleneck and extends the emission peak of the nanoparticles into the deeper optical tissue window.
Article
Engineering, Biomedical
Dennis Jones, Zixiong Wang, Ivy X. Chen, Sue Zhang, Rohin Banerji, Pin-Ji Lei, Hengbo Zhou, Victoria Xiao, Cecilia Kwong, Jan Willem M. van Wijnbergen, Ethel R. Pereira, Benjamin J. Vakoc, Peigen Huang, Hadi T. Nia, Timothy P. Padera
Summary: Metastatic lesions in lymph nodes generate solid stress that hinders lymphocyte infiltration, but relieving solid stress can significantly increase the presence of lymphocytes in lymph node lesions.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
Guillermo Arroyo-Ataz, Dennis Jones
Summary: This article presents methods and procedures for studying smooth muscle cells in lymphatic and blood vessels using in vivo and in vitro systems.
Review
Pathology
Samir Jana, Ronald A. Muscarella, Dennis Jones
Summary: This review provides an overview of how breast cancer cells modulate LN stromal and hematopoietic cells to promote metastasis and immune evasion, emphasizing the association between breast cancer and lymph node metastasis, as well as the immune response against breast cancer.
AMERICAN JOURNAL OF PATHOLOGY
(2021)