Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation

(2017) Lothar C. Dieterich et al.   Frontiers in Immunology

Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma

(2017) Abhishek D. Garg et al.   OncoImmunology

Anoxia and glucose supplementation preserve neutrophil viability and function

(2016) Valérie Monceaux et al.   BLOOD

Cancer immunotherapy: the beginning of the end of cancer?

(2016) Sofia Farkona et al.   BMC Medicine

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

(2016) Jin-Sung Park et al.   CANCER CELL

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

In SituTumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

(2016) Zachary S. Morris et al.   CANCER RESEARCH

Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation

(2016) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Immunologic heterogeneity of tumor-infiltrating lymphocyte composition in primary melanoma

(2016) Sarah A. Weiss et al.   HUMAN PATHOLOGY

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment

(2016) Hanna Starobinets et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

Immune checkpoint inhibitors: the new frontier in non–small cell lung cancer treatment

(2016) Hazem El-Osta et al.   OncoTargets and Therapy

Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer

(2015) Guangmei Mao et al.   ANGIOGENESIS

Targeting the tumor vasculature to enhance T cell activity

(2015) Evripidis Lanitis et al.   CURRENT OPINION IN IMMUNOLOGY

Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies

(2015) Hannelore Maes et al.   FEBS Journal

Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes

(2015) Yohko Nakagawa et al.   IMMUNOLOGY LETTERS

The Pleiotropic Effects of miRNAs on Tumor Angiogenesis

(2015) Runting Yin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer

(2015) Lan Lu et al.   JOURNAL OF CONTROLLED RELEASE

VEGF-A modulates expression of inhibitory checkpoints on CD8+T cells in tumors

(2015) Thibault Voron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model

(2015) Nicolle H. Rekers et al.   RADIOTHERAPY AND ONCOLOGY

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

(2015) Claire Vanpouille-Box et al.   VACCINE

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

(2015) Lee B. Rivera et al.   Cell Reports

Galectin-3 Shapes Antitumor Immune Responses by Suppressing CD8+ T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

(2015) T. Kouo et al.   Cancer Immunology Research

Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

(2015) C. M. L. Zegers et al.   CLINICAL CANCER RESEARCH

Pressing the right buttons: signaling in lymphangiogenesis

(2014) S. Coso et al.   BLOOD

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism

(2014) Peter Stapor et al.   JOURNAL OF CELL SCIENCE

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma

(2014) S. Kusmartsev et al.   JOURNAL OF IMMUNOLOGY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

The Value of Tumor Infiltrating Lymphocytes (TILs) for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer: A Systematic Review and Meta-Analysis

(2014) Yan Mao et al.   PLoS One

MicroRNAs and Tumor Vasculature Normalization: Impact on Anti-Tumor Immune Response

(2013) Agata Matejuk et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

(2013) Rikke B. Holmgaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of acute toxicity and mortality after two different dosing regimens of high-dose interleukin-2 for patients with metastatic melanoma

(2013) Laura M. Alwan et al.   Targeted Oncology

The New Era of the Lymphatic System: No Longer Secondary to the Blood Vascular System

(2013) I. Choi et al.   Cold Spring Harbor Perspectives in Medicine

Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

(2012) Jason G. Cyster et al.   Annual Review of Immunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Inhibiting Systemic Autophagy during Interleukin 2 Immunotherapy Promotes Long-term Tumor Regression

(2012) X. Liang et al.   CANCER RESEARCH

Targeting TNF-  to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy

(2012) A. Calcinotto et al.   JOURNAL OF IMMUNOLOGY

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

(2012) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma

(2011) T. K. Eigentler et al.   CLINICAL CANCER RESEARCH

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

(2011) Barbara Molon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 Mediates the Transmigration of Regulatory T Cells across Human Hepatic Sinusoidal Endothelium

(2011) Shishir Shetty et al.   JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Interaction of tumor cells and lymphatic vessels in cancer progression

(2011) A Alitalo et al.   ONCOGENE

TGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth

(2011) T J Standiford et al.   ONCOGENE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response

(2010) Anna I. Markowska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

The VEGF IRESes are differentially susceptible to translation inhibition by miR-16

(2009) Z. S. Karaa et al.   RNA

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

(2008) Takuya Osada et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE