Journal
SMALL
Volume 16, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201905424
Keywords
apoptosis; cancer; magnetic nanocubes; magnetomechanical destruction; mitochondrial
Categories
Funding
- NSFC [81571803, 31870997]
- NIH [R35CA197725]
- Shanghai Municipal Education Commission Innovative Program [2017-01-07-00-07-E00038]
- Science and Technology Commission of Shanghai Municipality [17431906600]
- Shanghai Science and International Cooperation Program [16410724300]
- Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone for Stem Cell Strategic Biobank and Stem Cell Clinical Technology Transformation Platform
- Fundamental Research Funds for the Central Universities
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In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion.
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