Rational Design of Nanoparticles with Deep Tumor Penetration for Effective Treatment of Tumor Metastasis

Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells

(2018) Yaqi Lv et al.   ACS Nano

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

(2018) Wen Song et al.   ACS Nano

Reassembly of 89 Zr-Labeled Cancer Cell Membranes into Multicompartment Membrane-Derived Liposomes for PET-Trackable Tumor-Targeted Theranostics

(2018) Bo Yu et al.   ADVANCED MATERIALS

Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy

(2018) Arunkumar Pitchaimani et al.   BIOMATERIALS

Engineering the Surface of Therapeutic “Living” Cells

(2018) Jooyeon Park et al.   CHEMICAL REVIEWS

Deep Tumor Penetrating Bioparticulates Inspired Burst Intracellular Drug Release for Precision Chemo-Phototherapy

(2018) Ruoning Wang et al.   Small

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition

(2017) Wei Li et al.   International Journal of Nanomedicine

Enhanced tumor therapy via drug co-delivery and in situ vascular-promoting strategy

(2017) Mingxing Yin et al.   JOURNAL OF CONTROLLED RELEASE

Normalizing Tumor Vessels To Increase the Enzyme-Induced Retention and Targeting of Gold Nanoparticle for Breast Cancer Imaging and Treatment

(2017) Wei Xiao et al.   MOLECULAR PHARMACEUTICS

Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control

(2017) Zipeng Zhen et al.   NANO LETTERS

Tumor-Penetrating Nanosystem Strongly Suppresses Breast Tumor Growth

(2017) Shweta Sharma et al.   NANO LETTERS

Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors

(2017) Tingting Wang et al.   NANO LETTERS

Inflammatory Monocytes Loading Protease-Sensitive Nanoparticles Enable Lung Metastasis Targeting and Intelligent Drug Release for Anti-Metastasis Therapy

(2017) Xinyu He et al.   NANO LETTERS

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Understanding cancer from the stem cells up

(2017) Christopher A Eide et al.   NATURE MEDICINE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Origins of lymphatic and distant metastases in human colorectal cancer

(2017) Kamila Naxerova et al.   SCIENCE

Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

(2017) Miles A. Miller et al.   Science Translational Medicine

Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2–mediated angiogenesis

(2017) Fan Pan et al.   TUMOR BIOLOGY

Enhancing Nanoparticle Accumulation and Retention in Desmoplastic Tumors via Vascular Disruption for Internal Radiation Therapy

(2017) Andrew B. Satterlee et al.   Theranostics

Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

(2017) Suping Li et al.   Nature Biomedical Engineering

Surveillance nanotechnology for multi-organ cancer metastases

(2017) Harini Kantamneni et al.   Nature Biomedical Engineering

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy

(2017) Yuekui Zhao et al.   Scientific Reports

Intracellularly Acid-Switchable Multifunctional Micelles for Combinational Photo/Chemotherapy of the Drug-Resistant Tumor

(2016) Tingting Wang et al.   ACS Nano

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors

(2016) Lei Miao et al.   ACS Nano

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

(2016) Haiqiang Cao et al.   ACS Nano

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

(2016) Tingting Lin et al.   ACS Nano

Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

(2016) Ze Chen et al.   ACS Nano

Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly( d , l -lactic acid)

(2016) Guoying Wang et al.   Acta Biomaterialia

Fibronectin-targeted drug delivery in cancer

(2016) Heena Kumra et al.   ADVANCED DRUG DELIVERY REVIEWS

Heterogeneity of tumor endothelial cells and drug delivery

(2016) Kyoko Hida et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro cancer cell–ECM interactions inform in vivo cancer treatment

(2016) Andrew W. Holle et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Drug delivery with living cells

(2016) Lies A.L. Fliervoet et al.   ADVANCED DRUG DELIVERY REVIEWS

The extracellular matrix in breast cancer

(2016) Jacob Insua-Rodríguez et al.   ADVANCED DRUG DELIVERY REVIEWS

Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration

(2016) Lijuan Zeng et al.   ADVANCED FUNCTIONAL MATERIALS

Versatile Prodrug Nanoparticles for Acid-Triggered Precise Imaging and Organelle-Specific Combination Cancer Therapy

(2016) Bing Feng et al.   ADVANCED FUNCTIONAL MATERIALS

Cancer Cell Membrane-Coated Gold Nanocages with Hyperthermia-Triggered Drug Release and Homotypic Target Inhibit Growth and Metastasis of Breast Cancer

(2016) Huiping Sun et al.   ADVANCED FUNCTIONAL MATERIALS

Bioinspired Nanoparticles with NIR-Controlled Drug Release for Synergetic Chemophotothermal Therapy of Metastatic Breast Cancer

(2016) Jinghan Su et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

(2016) Shan Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Long Circulation Red-Blood-Cell-Mimetic Nanoparticles with Peptide-Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer

(2016) Jinghan Su et al.   ADVANCED FUNCTIONAL MATERIALS

Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

(2016) Huiping Sun et al.   ADVANCED MATERIALS

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

(2016) Nasha Qiu et al.   ADVANCED MATERIALS

Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy

(2016) Jing Wang et al.   ADVANCED MATERIALS

Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy

(2016) Xiaoding Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor priming using metronomic chemotherapy with neovasculature-targeted, nanoparticulate paclitaxel

(2016) Xin Luan et al.   BIOMATERIALS

Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer

(2016) Bo Zhang et al.   BIOMATERIALS

Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition

(2016) Zu-Qi Zuo et al.   BIOMATERIALS

Nanomedicine-mediated cancer stem cell therapy

(2016) Song Shen et al.   BIOMATERIALS

Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy

(2016) Xiaoqing Ren et al.   BIOMATERIALS

Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy

(2016) Chao Liang et al.   CHEMICAL SOCIETY REVIEWS

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Sonoporation enhances liposome accumulation and penetration in tumors with low EPR

(2016) Benjamin Theek et al.   JOURNAL OF CONTROLLED RELEASE

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Preferential Cancer Cell Self-Recognition and Tumor Self-Targeting by Coating Nanoparticles with Homotypic Cancer Cell Membranes

(2016) Jing-Yi Zhu et al.   NANO LETTERS

Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines

(2016) Hong-Xia Wang et al.   Nano Today

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

(2016) Yu Matsumoto et al.   Nature Nanotechnology

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

(2016) Yufang Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neutrophils promote metastasis

(2016) T. Tuting et al.   SCIENCE

Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy

(2016) Jingxing Si et al.   Small

A cooperative polymeric platform for tumor-targeted drug delivery

(2016) Wantong Song et al.   Chemical Science

Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma

(2016) Juli R. Bagó et al.   Nature Communications

Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization

(2016) Yi-Ju Ho et al.   Theranostics

Active Tumor Permeation and Uptake of Surface Charge-Switchable Theranostic Nanoparticles for Imaging-Guided Photothermal/Chemo Combinatorial Therapy

(2016) Chia-Chian Hung et al.   Theranostics

Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics

(2016) Lili Zou et al.   Theranostics

Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma

(2015) Yuanyuan Guo et al.   ACS Nano

Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers

(2015) Horacio Cabral et al.   ACS Nano

MRI Virtual Biopsy and Treatment of Brain Metastatic Tumors with Targeted Nanobioconjugates: Nanoclinic in the Brain

(2015) Rameshwar Patil et al.   ACS Nano

Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles

(2015) Ruirui Qiao et al.   ACS Nano

Delivery of RNA Nanoparticles into Colorectal Cancer Metastases Following Systemic Administration

(2015) Piotr Rychahou et al.   ACS Nano

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

(2015) Jinqiang Wang et al.   ACS Nano

Spatiotemporal Targeting of a Dual-Ligand Nanoparticle to Cancer Metastasis

(2015) Elizabeth Doolittle et al.   ACS Nano

Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread

(2015) Christian Büll et al.   ACS Nano

A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics

(2015) Liyang Cui et al.   ACS Nano

Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy

(2015) Seokyung Kang et al.   ACS Nano

Virus-Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor-Specific Infection and Systemic Drug Delivery

(2015) Zhijun Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

(2015) Xinyu He et al.   ADVANCED FUNCTIONAL MATERIALS

pH- and NIR Light-Responsive Micelles with Hyperthermia-Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

(2015) Haijun Yu et al.   ADVANCED FUNCTIONAL MATERIALS

Peptide Assembly Integration of Fibroblast-Targeting and Cell-Penetration Features for Enhanced Antitumor Drug Delivery

(2015) Tianjiao Ji et al.   ADVANCED MATERIALS

A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy

(2015) Ya Liu et al.   ADVANCED MATERIALS

Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer

(2015) Pengfei Xu et al.   BIOMATERIALS

Photochemical tissue penetration via photosensitizer for effective drug penetration in a non-vascular tumor

(2015) Daehong Min et al.   BIOMATERIALS

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

(2015) Wen-Chia Huang et al.   BIOMATERIALS

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

(2015) Shaobo Ruan et al.   BIOMATERIALS

Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models

(2015) Mingqiang Li et al.   BIOMATERIALS

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2015) Berna C. Özdemir et al.   CANCER CELL

Development of individualized anti-metastasis strategies by engineering nanomedicines

(2015) Qianjun He et al.   CHEMICAL SOCIETY REVIEWS

Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice

(2015) Tian-Yuan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Improving drug delivery to solid tumors: Priming the tumor microenvironment

(2015) Iftikhar Ali Khawar et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer

(2015) Jijun Fu et al.   JOURNAL OF CONTROLLED RELEASE

Tumor Acidity-Sensitive Polymeric Vector for Active Targeted siRNA Delivery

(2015) Chun-Yang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

(2015) Sijumon Kunjachan et al.   NANO LETTERS

Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration

(2015) Junsung Lee et al.   NANO LETTERS

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Influence of vascular normalization on interstitial flow and delivery of liposomes in tumors

(2015) Deniz Ozturk et al.   PHYSICS IN MEDICINE AND BIOLOGY

Designer cells finely tuned for therapy

(2015) J. Di Domizio et al.   SCIENCE

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Hurdles in therapy with regulatory T cells

(2015) Piotr Trzonkowski et al.   Science Translational Medicine

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

Superior Intratumoral Penetration of Paclitaxel Nanodots Strengthens Tumor Restriction and Metastasis Prevention

(2015) Dezhi Ni et al.   Small

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

(2015) Miles A. Miller et al.   Nature Communications

pH-Responsive Wormlike Micelles with Sequential Metastasis Targeting Inhibit Lung Metastasis of Breast Cancer

(2015) Xinyu He et al.   Advanced Healthcare Materials

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

(2014) Kvar C. L. Black et al.   ACS Nano

Co-delivery of Cisplatin and Rapamycin for Enhanced Anticancer Therapy through Synergistic Effects and Microenvironment Modulation

(2014) Shutao Guo et al.   ACS Nano

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

(2014) Edward A. Sykes et al.   ACS Nano

Neural Stem Cell-Mediated Intratumoral Delivery of Gold Nanorods Improves Photothermal Therapy

(2014) Rachael Mooney et al.   ACS Nano

Stem Cells Loaded with Nanoparticles as a Drug Carrier for In Vivo Breast Cancer Therapy

(2014) Binrui Cao et al.   ADVANCED MATERIALS

An Imagable and Photothermal “Abraxane-Like” Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors

(2014) Qian Chen et al.   ADVANCED MATERIALS

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery

(2014) Qian Chen et al.   BIOMATERIALS

Delivery of platinum(IV) drug to subcutaneous tumor and lung metastasis using bradykinin-potentiating peptide-decorated chitosan nanoparticles

(2014) Xin Wang et al.   BIOMATERIALS

Lipid–calcium phosphate nanoparticles for delivery to the lymphatic system and SPECT/CT imaging of lymph node metastases

(2014) Yu-Cheng Tseng et al.   BIOMATERIALS

Near Infrared Laser-Induced Targeted Cancer Therapy Using Thermoresponsive Polymer Encapsulated Gold Nanorods

(2014) Zhenjiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions

(2014) Xinpeng Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Investigating the optimal size of anticancer nanomedicine

(2014) L. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

(2014) Ze Liu et al.   Nature Communications

Effect of Folate-Targeted Nanoparticle Size on Their Rates of Penetration into Solid Tumors

(2013) Erina Vlashi et al.   ACS Nano

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors

(2013) Lei Qin et al.   JOURNAL OF CONTROLLED RELEASE

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

(2013) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

(2013) Naama E. Toledano Furman et al.   NANO LETTERS

Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo

(2013) Tuo Wei et al.   NANO LETTERS

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

A biomimetic nanosponge that absorbs pore-forming toxins

(2013) Che-Ming J. Hu et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Photoswitchable nanoparticles for in vivo cancer chemotherapy

(2013) R. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis

(2013) H. Cabral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining two strategies to improve perfusion and drug delivery in solid tumors

(2013) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

(2013) P. Kolhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Metastasis Using an Integrin-Targeting Chain-Shaped Nanoparticle

(2012) Pubudu M. Peiris et al.   ACS Nano

Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting

(2012) Lin Zhu et al.   ACS Nano

Markedly Enhanced Permeability and Retention Effects Induced by Photo-immunotherapy of Tumors

(2012) Kohei Sano et al.   ACS Nano

Targeting of Primary Breast Cancers and Metastases in a Transgenic Mouse Model Using Rationally Designed Multifunctional SPIONs

(2012) Forrest M. Kievit et al.   ACS Nano

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

(2012) Li Tang et al.   ACS Nano

Targeting Efficiency and Biodistribution of Zoledronate Conjugated Docetaxel Loaded Pegylated PBCA Nanoparticles for Bone Metastasis

(2012) Kiran R. Chaudhari et al.   ADVANCED FUNCTIONAL MATERIALS

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

(2012) You-Yong Yuan et al.   ADVANCED MATERIALS

Peptides as Targeting Elements and Tissue Penetration Devices for Nanoparticles

(2012) Erkki Ruoslahti   ADVANCED MATERIALS

Use of macrophages to deliver therapeutic and imaging contrast agents to tumors

(2012) Jinhyang Choi et al.   BIOMATERIALS

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery

(2012) Erlei Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticle Loaded Poly(lactide-co-glycolide) Microparticles

(2012) Chenjie Xu et al.   NANO LETTERS

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

TGF-  blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

(2012) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4

(2012) Y. Ren et al.   Science Translational Medicine

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

(2012) Y.-d. Yao et al.   Science Translational Medicine

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

(2012) J. Hrkach et al.   Science Translational Medicine

Physicochemical Characteristics of Nanoparticles Affect Circulation, Biodistribution, Cellular Internalization, and Trafficking

(2012) Xiaopin Duan et al.   Small

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Lipoprotein-Inspired Nanoparticles for Cancer Theranostics

(2011) Kenneth K. Ng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Silica Nanorattle–Doxorubicin-Anchored Mesenchymal Stem Cells for Tumor-Tropic Therapy

(2011) Linlin Li et al.   ACS Nano

Mesenchymal stem cells engineered for cancer therapy

(2011) Khalid Shah   ADVANCED DRUG DELIVERY REVIEWS

Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis

(2011) Michael E. Werner et al.   BIOMATERIALS

Albumin-based nanoparticles as potential controlled release drug delivery systems

(2011) Ahmed O. Elzoghby et al.   JOURNAL OF CONTROLLED RELEASE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivering nanomedicine to solid tumors

(2010) Rakesh K. Jain et al.   Nature Reviews Clinical Oncology

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Charge-Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery

(2009) Zhuxian Zhou et al.   ADVANCED FUNCTIONAL MATERIALS

Targeting Bone Metastases with a Bispecific Anticancer and Antiangiogenic Polymer-Alendronate-Taxane Conjugate

(2009) Keren Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY