Functional Nanoparticles for Tumor Penetration of Therapeutics

Self-Assembled Peptide–Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery

(2018) Jin Yan et al.   ACS Nano

Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

(2018) Chuan Hu et al.   BIOMATERIALS

Photosensitive Nanoparticles Combining Vascular-Independent Intratumor Distribution and On-Demand Oxygen-Depot Delivery for Enhanced Cancer Photodynamic Therapy

(2018) Caiyan Zhao et al.   Small

Deep Tumor Penetrating Bioparticulates Inspired Burst Intracellular Drug Release for Precision Chemo-Phototherapy

(2018) Ruoning Wang et al.   Small

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Simultaneously overcome tumor vascular endothelium and extracellular matrix barriers via a non-destructive size-controlled nanomedicine

(2017) Binghua Wang et al.   JOURNAL OF CONTROLLED RELEASE

Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery

(2017) Jae Hyeop Lee et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound

(2017) Sangmin Lee et al.   JOURNAL OF CONTROLLED RELEASE

Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

(2017) Juyoung Park et al.   JOURNAL OF CONTROLLED RELEASE

Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Rethinking cancer nanotheranostics

(2017) Hongmin Chen et al.   Nature Reviews Materials

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

Blood–Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy

(2016) Tingting Lin et al.   ACS Nano

The Penetrated Delivery of Drug and Energy to Tumors by Lipo-Graphene Nanosponges for Photolytic Therapy

(2016) Yu-Lin Su et al.   ACS Nano

Tumor-Microenvironment-Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer

(2016) Shan Tang et al.   ADVANCED FUNCTIONAL MATERIALS

Dual-Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy

(2016) Chien-Ting Lin et al.   ADVANCED FUNCTIONAL MATERIALS

Intelligent Albumin-MnO2Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

(2016) Qian Chen et al.   ADVANCED MATERIALS

Hypoxia Responsive, Tumor Penetrating Lipid Nanoparticles for Delivery of Chemotherapeutics to Pancreatic Cancer Cell Spheroids

(2016) Prajakta Kulkarni et al.   BIOCONJUGATE CHEMISTRY

Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery

(2016) Hyun Su Min et al.   BIOMATERIALS

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

(2016) Yu Matsumoto et al.   Nature Nanotechnology

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic nanoparticle-promoted droplet vaporization for in vivo stimuli-responsive cancer theranostics

(2016) Yang Zhou et al.   NPG Asia Materials

Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization

(2016) Yi-Ju Ho et al.   Theranostics

High Tumor Penetration of Paclitaxel Loaded pH Sensitive Cleavable Liposomes by Depletion of Tumor Collagen I in Breast Cancer

(2015) Li Zhang et al.   ACS Applied Materials & Interfaces

Tumor-Penetrating Nanotherapeutics Loading a Near-Infrared Probe Inhibit Growth and Metastasis of Breast Cancer

(2015) Xinyu He et al.   ADVANCED FUNCTIONAL MATERIALS

IF7-Conjugated Nanoparticles Target Annexin 1 of Tumor Vasculature against P-gp Mediated Multidrug Resistance

(2015) De-Hong Yu et al.   BIOCONJUGATE CHEMISTRY

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

(2015) Wen-Chia Huang et al.   BIOMATERIALS

Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release

(2015) Shaobo Ruan et al.   BIOMATERIALS

Toward Accumulation of Magnetic Nanoparticles into Tissues of Small Porosity

(2015) Rasam Soheilian et al.   LANGMUIR

Enhancing Glioblastoma-Specific Penetration by Functionalization of Nanoparticles with an Iron-Mimic Peptide Targeting Transferrin/Transferrin Receptor Complex

(2015) Ting Kang et al.   MOLECULAR PHARMACEUTICS

Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy

(2015) Sijumon Kunjachan et al.   NANO LETTERS

Targeted Mesoporous Iron Oxide Nanoparticles-Encapsulated Perfluorohexane and a Hydrophobic Drug for Deep Tumor Penetration and Therapy

(2015) Yu-Lin Su et al.   Theranostics

Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix

(2014) Alessandro Parodi et al.   ACS Nano

Tumor-Homing, Size-Tunable Clustered Nanoparticles for Anticancer Therapeutics

(2014) Jinhwan Kim et al.   ACS Nano

Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration

(2014) Caoyun Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

(2014) Wujin Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligo(ethylene glycol)-Based Thermosensitive Dendrimers and Their Tumor Accumulation and Penetration

(2014) Wei Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RGD and Interleukin-13 Peptide Functionalized Nanoparticles for Enhanced Glioblastoma Cells and Neovasculature Dual Targeting Delivery and Elevated Tumor Penetration

(2014) Huile Gao et al.   MOLECULAR PHARMACEUTICS

Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

(2014) Hisataka Kobayashi et al.   Theranostics

Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

(2013) Yutaka Miura et al.   ACS Nano

Co-administration of Dual-Targeting Nanoparticles with Penetration Enhancement Peptide for Antiglioblastoma Therapy

(2013) Deyu Miao et al.   MOLECULAR PHARMACEUTICS

Size-Dependent Tumor Penetration and in Vivo Efficacy of Monodisperse Drug–Silica Nanoconjugates

(2013) Li Tang et al.   MOLECULAR PHARMACEUTICS

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Photoswitchable nanoparticles for in vivo cancer chemotherapy

(2013) R. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery

(2012) Rong Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide

(2011) S. Hatakeyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release

(2010) Seong Deok Kong et al.   NANO LETTERS