A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

(2019) Morgan L. Maeder et al.   NATURE MEDICINE

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

(2018) Ling Li et al.   BIOMATERIALS

Non-Viral Delivery To Enable Genome Editing

(2018) Yuan Rui et al.   TRENDS IN BIOTECHNOLOGY

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

(2018) Jichao Sun et al.   Nature Communications

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

(2017) Brett T Staahl et al.   NATURE BIOTECHNOLOGY

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

(2017) Fabao Liu et al.   NATURE CELL BIOLOGY

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

Assembly of CRISPR ribonucleoproteins with biotinylated oligonucleotides via an RNA aptamer for precise gene editing

(2017) Jared Carlson-Stevermer et al.   Nature Communications

Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber’s Congenital Amaurosis

(2017) Da Sun et al.   Molecular Therapy-Nucleic Acids

High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells

(2016) Benjamin Steyer et al.   Acta Biomaterialia

Cas-analyzer: an online tool for assessing genome editing results using NGS data

(2016) Jeongbin Park et al.   BIOINFORMATICS

Disulfide-functional poly(amido amine)s with tunable degradability for gene delivery

(2016) M. Rachèl Elzes et al.   JOURNAL OF CONTROLLED RELEASE

High-Content Analysis of CRISPR-Cas9 Gene-Edited Human Embryonic Stem Cells

(2016) Jared Carlson-Stevermer et al.   Stem Cell Reports

Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging

(2015) Guojun Chen et al.   BIOMATERIALS

High-content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics

(2015) Ty Harkness et al.   Biotechnology Journal

Challenges in CRISPR/CAS9 Delivery: Potential Roles of Nonviral Vectors

(2015) Ling Li et al.   HUMAN GENE THERAPY

Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells

(2015) Jia Liu et al.   Nature Protocols

High-content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics

(2015) Ty Harkness et al.   Biotechnology Journal

Long-Term Storage of Lyophilized Liposomal Formulations

(2014) Nicole M. Payton et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein

(2014) Muxun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Intracellular drug release nanosystems

(2012) Fenghua Meng et al.   Materials Today

The molecular basis of human retinal and vitreoretinal diseases

(2010) Wolfgang Berger et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network

(2009) Zhen Gu et al.   NANO LETTERS

A novel intracellular protein delivery platform based on single-protein nanocapsules

(2009) Ming Yan et al.   Nature Nanotechnology