The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment
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Title
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment
Authors
Keywords
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Journal
Cancer Cell International
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-20
DOI
10.1186/s12935-020-01719-5
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Note: Only part of the references are listed.- The protective effects of microRNA-26a in steroid-induced osteonecrosis of the femoral head by repressing EZH2
- (2020) Gang Li et al. CELL CYCLE
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- (2020) Yao-An Shen et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles
- (2020) Heba T. Abdel-Mohsen et al. MOLECULES
- Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway
- (2020) Yingjun Zhu et al. Frontiers in Pharmacology
- Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies
- (2020) Shaghayegh Haghjooy Javanmard et al. Cancer Cell International
- Hypoxia in tumor microenvironment regulates exosome biogenesis: Molecular mechanisms and translational opportunities
- (2020) Ashish Kumar et al. CANCER LETTERS
- Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells.
- (2020) Nazila Fathi Maroufi et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- HIF-1α protects against oxidative stress by directly targeting mitochondria
- (2019) Hong-Sheng Li et al. Redox Biology
- Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells
- (2019) Bai Cui et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer cell–induced neutrophil extracellular traps promote both hypercoagulability and cancer progression
- (2019) Hye Soo Jung et al. PLoS One
- Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects
- (2019) Anoop K. Yadav et al. Stem Cell Reviews and Reports
- Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells
- (2019) Abril Saint-Martin et al. Cancers
- Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression
- (2019) Junli Deng et al. BMC CANCER
- Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors
- (2019) Amit Hagar et al. BMC CANCER
- New trends in glioma cancer therapy: Targeting Na+ /H + exchangers
- (2019) Omid Reza Tamtaji et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Tumor‐derived exosomes (TDEs): How to avoid the sting in the tail
- (2019) MeiHua Wan et al. MEDICINAL RESEARCH REVIEWS
- Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence
- (2019) Inchul J. Cho et al. Stem Cell Reports
- New Insight into Therapies Targeting Angiogenesis in Hepatocellular Carcinoma
- (2019) Mossenta et al. Cancers
- Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion
- (2019) Wai Hoong Chang et al. BRITISH JOURNAL OF CANCER
- Latest Advances in Targeting the Tumor Microenvironment for Tumor Suppression
- (2019) Chloé Laplagne et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies
- (2019) Salvador Harguindey et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hypoxic Regulation of Neutrophils in Cancer
- (2019) Daniel Triner et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival
- (2019) Mary C. Patton et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance
- (2019) Masoud Najafi et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells
- (2019) Farnaz Hajizadeh et al. LIFE SCIENCES
- Role of hypoxia in cancer therapy by regulating the tumor microenvironment
- (2019) Xinming Jing et al. Molecular Cancer
- Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications
- (2019) Tiziana Tataranni et al. Oxidative Medicine and Cellular Longevity
- LOXL 2 Promotes The Epithelial–Mesenchymal Transition And Malignant Progression Of Cervical Cancer
- (2019) Jing Tian et al. OncoTargets and Therapy
- Interleukin-15 Signaling in HIF-1α Regulation in Natural Killer Cells, Insights Through Mathematical Models
- (2019) Anna Coulibaly et al. Frontiers in Immunology
- T Regulatory Cells and Priming the Suppressive Tumor Microenvironment
- (2019) Christina M. Paluskievicz et al. Frontiers in Immunology
- Are ENT1/ENT1, NOTCH3, and miR-21 Reliable Prognostic Biomarkers in Patients with Resected Pancreatic Adenocarcinoma Treated with Adjuvant Gemcitabine Monotherapy?
- (2019) Lucie Jiraskova et al. Cancers
- Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment
- (2019) Hao-Ran Sun et al. Frontiers in Oncology
- Carbonic anhydrase IX and acid transport in cancer
- (2019) Holger M. Becker BRITISH JOURNAL OF CANCER
- Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma
- (2019) Soumya R. Mohapatra et al. Frontiers in Immunology
- microRNA: The Impact on Cancer Stemness and Therapeutic Resistance
- (2019) Xueqiao Jiao et al. Cells
- Investigations into the cancer stem cell niche using in-vitro 3-D tumor models and microfluidics
- (2018) M. Sreepadmanabh et al. BIOTECHNOLOGY ADVANCES
- Targeting tumor-associated acidity in cancer immunotherapy
- (2018) Ruben Lacroix et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Metabolic traits of cancer stem cells
- (2018) Joana Peixoto et al. Disease Models & Mechanisms
- In vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells and the related mechanism
- (2018) Qianwen Shao et al. International Journal of Medical Sciences
- Cross regulation between mTOR signaling and O-GlcNAcylation
- (2018) Ninon Very et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions
- (2018) Tzu-Sheng Hsu et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Intermittent hypoxia induces a metastatic phenotype in breast cancer
- (2018) Anna Chen et al. ONCOGENE
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer
- (2018) Xudong Peng et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Up-regulation of miR-210 induced by a hypoxic microenvironment promotes breast cancer stem cells metastasis, proliferation, and self-renewal by targeting E-cadherin
- (2018) Tingting Tang et al. FASEB JOURNAL
- miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways
- (2018) Lu-Qin Wang et al. Molecular Oncology
- Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment
- (2018) Kaitlin Graham et al. International Journal of Nanomedicine
- Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
- (2018) Priyamvada Jayaprakash et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways
- (2018) Yuanyuan Yan et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules
- (2018) Zaira Boussadia et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling
- (2018) Zhengle Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC
- (2018) Xiaoyuan Wang et al. Stem Cell Research & Therapy
- Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer
- (2018) Jesse M. Mast et al. Frontiers in Oncology
- Serum miR-21 and miR-125b as markers predicting neoadjuvant chemotherapy response and prognosis in stage II/III breast cancer
- (2017) Baoquan Liu et al. HUMAN PATHOLOGY
- Roles of Wnt Target Genes in the Journey of Cancer Stem Cells
- (2017) Jee-Heun Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Metastatic Breast Cancer Cells Enter Into Dormant State and Express Cancer Stem Cells Phenotype Under Chronic Hypoxia
- (2017) Alessandra Carcereri de Prati et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Tariquidar sensitizes multiple myeloma cells to proteasome inhibitors via reduction of hypoxia-induced P-gp-mediated drug resistance
- (2017) Barbara Muz et al. LEUKEMIA & LYMPHOMA
- Inhibition of microRNA-21 via locked nucleic acid-anti-miR suppressed metastatic features of colorectal cancer cells through modulation of programmed cell death 4
- (2017) Reza Nedaeinia et al. TUMOR BIOLOGY
- Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
- (2017) David Kung-Chun Chiu et al. Nature Communications
- Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)
- (2017) Ernestina Marianna De Francesco et al. Oncotarget
- Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function
- (2017) Yael Gropper et al. Cell Reports
- CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells
- (2017) Elinn Johansson et al. Cell Reports
- Programmed cell death ligands expression in phaeochromocytomas and paragangliomas: Relationship with the hypoxic response, immune evasion and malignant behavior
- (2017) David J. Pinato et al. OncoImmunology
- Modulatory roles of microRNAs in the regulation of different signalling pathways in large bowel cancer stem cells
- (2016) Afraa Mamoori et al. BIOLOGY OF THE CELL
- Locked nucleic acid anti-miR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line: LNA-anti-miR as a novel approach
- (2016) R Nedaeinia et al. CANCER GENE THERAPY
- Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer
- (2016) R Nedaeinia et al. CANCER GENE THERAPY
- Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces
- (2016) M. C. Lloyd et al. CANCER RESEARCH
- Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress
- (2016) Samer Tohme et al. CANCER RESEARCH
- Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status
- (2016) Yosra Messai et al. EUROPEAN UROLOGY
- Tackling multidrug resistance mediated by efflux transporters in tumor-initiating cells
- (2016) Kyle McIntosh et al. Expert Opinion on Drug Metabolism & Toxicology
- Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)
- (2016) Carrie Lomelino et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26
- (2016) David Kung-Chun Chiu et al. HEPATOLOGY
- Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma
- (2016) Alan Ka-Lun Kai et al. HEPATOLOGY
- PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma
- (2016) Melanie Ruf et al. INTERNATIONAL JOURNAL OF CANCER
- Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities
- (2016) Sonia Y. Velásquez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2
- (2016) De-Ning Ma et al. Journal of Hematology & Oncology
- Epithelial Hypoxia-Inducible Factor 2α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils
- (2016) Daniel Triner et al. MOLECULAR AND CELLULAR BIOLOGY
- S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
- (2016) Petros A. Tyrakis et al. NATURE
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
- (2016) Caroline Wigerup et al. PHARMACOLOGY & THERAPEUTICS
- Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer
- (2016) Eun Jin Seo et al. Oncotarget
- Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer
- (2016) Li Ren et al. Oncotarget
- Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy
- (2016) Wanyin Chen et al. Stem Cells International
- Pathophysiological Basis for the Formation of the Tumor Microenvironment
- (2016) Michael R. Horsman et al. Frontiers in Oncology
- Histological Characterization of the Tumorigenic “Peri-Necrotic Niche” Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma
- (2016) Aya Ishii et al. PLoS One
- Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis
- (2016) Samriddhi Shukla et al. Scientific Reports
- Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
- (2015) Vincenzo Giambra et al. BLOOD
- Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells
- (2015) Adam Blaisdell et al. CANCER CELL
- Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210
- (2015) Muhammad Zaeem Noman et al. CANCER RESEARCH
- Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
- (2015) Shari Pilon-Thomas et al. CANCER RESEARCH
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality
- (2015) A. McIntyre et al. EMBO Molecular Medicine
- Evodiamine, a novel inhibitor of the Wnt pathway, inhibits the self-renewal of gastric cancer stem cells
- (2015) ZHENZHEN WEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Randomized Phase II Trial of Gemcitabine Plus TH-302 Versus Gemcitabine in Patients With Advanced Pancreatic Cancer
- (2015) Mitesh J. Borad et al. JOURNAL OF CLINICAL ONCOLOGY
- Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
- (2015) Haiquan Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer as a channelopathy: ion channels and pumps in tumor development and progression
- (2015) Alisa Litan et al. Frontiers in Cellular Neuroscience
- Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
- (2015) Huey-Wen Hsiao et al. Nature Communications
- Wnt blockers inhibit the proliferation of lung cancer stem cells
- (2015) Baohui Han et al. Drug Design Development and Therapy
- Proton pump inhibitors enhance the effects of cytotoxic agents in chemoresistant epithelial ovarian carcinoma
- (2015) Yoo-Young Lee et al. Oncotarget
- Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition
- (2015) Ioanna Ledaki et al. Oncotarget
- Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells
- (2015) Hui-Mei Wu et al. Scientific Reports
- Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer
- (2015) Jitka Y. Sagiv et al. Cell Reports
- Mechanisms Of Hypoxia-Induced Immune Escape In Cancer And Their Regulation By Nitric Oxide
- (2015) Charles Graham et al. Redox Biology
- Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
- (2014) Jillian Brechbiel et al. CANCER TREATMENT REVIEWS
- EGFR as a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies
- (2014) Reza Nedaeinia et al. CURRENT DRUG TARGETS
- Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
- (2014) Eric L. Campbell et al. IMMUNITY
- The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor
- (2014) Tian-zhu Liu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Phase II Study of the Safety and Antitumor Activity of the Hypoxia-Activated Prodrug TH-302 in Combination With Doxorubicin in Patients With Advanced Soft Tissue Sarcoma
- (2014) Sant P. Chawla et al. JOURNAL OF CLINICAL ONCOLOGY
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
- (2014) Muhammad Zaeem Noman et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The role of P-glycoprotein in drug resistance in multiple myeloma
- (2014) Joseph Abraham et al. LEUKEMIA & LYMPHOMA
- HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells
- (2014) Maximilian Marhold et al. MOLECULAR CANCER RESEARCH
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis
- (2014) L Zeng et al. ONCOGENE
- ABC Transporters in Multi-Drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors
- (2014) Jiexin Deng et al. PHARMACEUTICAL RESEARCH
- Ion channels in cancer: future perspectives and clinical potential
- (2014) F. Lang et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Ion channels and transporters in tumour cell migration and invasion
- (2014) A. Schwab et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- HIF-1α and HIF-2α: Siblings in Promoting Angiogenesis of Residual Hepatocellular Carcinoma after High-Intensity Focused Ultrasound Ablation
- (2014) Lun Wu et al. PLoS One
- Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells
- (2014) Debangshu Samanta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop
- (2014) Shravanti Mukherjee et al. Stem Cell Research & Therapy
- In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer
- (2013) Bo Ri Seo et al. ADVANCED DRUG DELIVERY REVIEWS
- Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells
- (2013) Klaas M. Govaert et al. ANNALS OF SURGERY
- Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
- (2013) Andrea Casazza et al. CANCER CELL
- SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1 -Dependent Glycolysis
- (2013) G. Liu et al. CANCER RESEARCH
- MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling
- (2013) Su Jung Song et al. CELL
- miR-22 in tumorigenesis
- (2013) Su Jung Song et al. CELL CYCLE
- MicroRNA aberrances in head and neck cancer
- (2013) Hsi-Feng Tu et al. Current Opinion in Otolaryngology & Head and Neck Surgery
- The tumor microenvironment at a glance
- (2013) F. R. Balkwill et al. JOURNAL OF CELL SCIENCE
- MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells
- (2013) Q. Wu et al. JOURNAL OF CELL SCIENCE
- Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
- (2013) Murielle Mimeault et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
- (2013) Andrew L Doedens et al. NATURE IMMUNOLOGY
- Downregulated microRNA-200a promotes EMT and tumor growth through the Wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma
- (2013) NINGNING CONG et al. ONCOLOGY REPORTS
- MicroRNA-21 in Pancreatic Ductal Adenocarcinoma Tumor-Associated Fibroblasts Promotes Metastasis
- (2013) Brian E. Kadera et al. PLoS One
- Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
- (2013) P. Mao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- What makes cancer stem cell markers different?
- (2013) Uwe Karsten et al. SpringerPlus
- Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer
- (2012) Chi-Tai Yeh et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
- (2012) Bin Bao et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α
- (2012) Ran-Ju Kim et al. CANCER LETTERS
- Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
- (2012) T. Fiaschi et al. CANCER RESEARCH
- Targeting CSC-Related miRNAs for Cancer Therapy by Natural Agents
- (2012) Bin Bao et al. CURRENT DRUG TARGETS
- Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors
- (2012) Chan Yeom et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes
- (2012) Nicolas Skuli et al. JOURNAL OF CLINICAL INVESTIGATION
- Orthotopic glioblastoma stem-like cell xenograft model in mice to evaluate intra-arterial delivery of bevacizumab: From bedside to bench
- (2012) Jan-Karl Burkhardt et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth
- (2012) Wiebke Hansen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential in breast cancer
- (2012) Aleksandra Markiewicz et al. Journal of Translational Medicine
- Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
- (2012) F E Lock et al. ONCOGENE
- Intermittent Hypoxia Regulates Stem-like Characteristics and Differentiation of Neuroblastoma Cells
- (2012) Vasantha Kumar Bhaskara et al. PLoS One
- Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM
- (2012) Dejuan Kong et al. PLoS One
- Hypoxia-Induced Aggressiveness of Pancreatic Cancer Cells Is Due to Increased Expression of VEGF, IL-6 and miR-21, Which Can Be Attenuated by CDF Treatment
- (2012) Bin Bao et al. PLoS One
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Na+-H+ Exchanger, pH Regulation and Cancer
- (2012) Stephan J. Reshkin et al. Recent Patents on Anti-Cancer Drug Discovery
- Passing the baton: the HIF switch
- (2012) Mei Yee Koh et al. TRENDS IN BIOCHEMICAL SCIENCES
- Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21
- (2011) N. Tsuchiya et al. CANCER RESEARCH
- MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2
- (2011) J. Lu et al. CANCER RESEARCH
- Hypoxia Induces Escape from Innate Immunity in Cancer Cells via Increased Expression of ADAM10: Role of Nitric Oxide
- (2011) I. B. Barsoum et al. CANCER RESEARCH
- Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor microRNAs and Attenuating EZH2 Expression
- (2011) B. Bao et al. CANCER RESEARCH
- Cancer Stem Cell Niche: The Place to Be
- (2011) T. Borovski et al. CANCER RESEARCH
- HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
- (2011) L Qiang et al. CELL DEATH AND DIFFERENTIATION
- Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development
- (2011) K Moitra et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Myeloid-derived suppressor cells: a double-edged sword?
- (2011) Agnieszka Pastuła et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells
- (2011) Yunfei Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Hepatocellular Carcinoma Cells
- (2011) Zeng Yong Yi et al. JOURNAL OF INVESTIGATIVE SURGERY
- MicroRNA-101 Exerts Tumor-Suppressive Functions in Non-small Cell Lung Cancer through Directly Targeting Enhancer of Zeste Homolog 2
- (2011) Ji-guang Zhang et al. Journal of Thoracic Oncology
- Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
- (2011) Andrea Facciabene et al. NATURE
- microRNA-107 functions as a candidate tumor-suppressor gene in head and neck squamous cell carcinoma by downregulation of protein kinase Cɛ
- (2011) J Datta et al. ONCOGENE
- Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations
- (2011) S Floor et al. ONCOGENE
- MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
- (2011) Ling-Zhi Liu et al. PLoS One
- CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
- (2011) R. Le Floch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
- (2011) C. C.-L. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epithelial-Mesenchymal Transition in tumor microenvironment
- (2011) Yingying Jing et al. Cell and Bioscience
- microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity
- (2010) J Zhang et al. BRITISH JOURNAL OF CANCER
- Macrophage Expression of Hypoxia-Inducible Factor-1 Suppresses T-Cell Function and Promotes Tumor Progression
- (2010) A. L. Doedens et al. CANCER RESEARCH
- Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor
- (2010) H. Harrison et al. CANCER RESEARCH
- Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF
- (2010) Shadan Ali et al. CANCER RESEARCH
- The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents
- (2010) Dietmar W. Siemann CANCER TREATMENT REVIEWS
- An inhibitory effect of miR-22 on cell migration and invasion in ovarian cancer
- (2010) Jun Li et al. GYNECOLOGIC ONCOLOGY
- Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
- (2010) Einar K. Rofstad et al. INTERNATIONAL JOURNAL OF CANCER
- Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
- (2010) Johanna Chiche et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
- (2010) Hongxia Z. Imtiyaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
- (2010) Mitomu Kioi et al. JOURNAL OF CLINICAL INVESTIGATION
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
- (2010) Cesar A. Corzo et al. JOURNAL OF EXPERIMENTAL MEDICINE
- MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β
- (2010) Paul Cao et al. Molecular Cancer
- Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2-Neutralizing Peptibody
- (2010) A. Coxon et al. MOLECULAR CANCER THERAPEUTICS
- Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB
- (2010) Nadine Rohwer et al. PLoS One
- Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells
- (2010) Dejuan Kong et al. PLoS One
- P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
- (2010) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- microRNA-181b targets MLK2 in HL-60 cells
- (2010) Hong Chen et al. Science China-Life Sciences
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Quiescent, Slow-Cycling Stem Cell Populations in Cancer: A Review of the Evidence and Discussion of Significance
- (2010) Nathan Moore et al. Journal of Oncology
- Endothelial deletion of hypoxia-inducible factor-2 (HIF-2 ) alters vascular function and tumor angiogenesis
- (2009) N. Skuli et al. BLOOD
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
- (2009) Zvi G. Fridlender et al. CANCER CELL
- MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress
- (2009) M. E. Crosby et al. CANCER RESEARCH
- Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells
- (2009) Y. Li et al. CANCER RESEARCH
- Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
- (2009) Yohei Shimono et al. CELL
- VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
- (2009) Oscar Gonzalez-Moreno et al. EXPERIMENTAL CELL RESEARCH
- The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
- (2009) Ruth Schietke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of HIF-1 inhibitors for cancer therapy
- (2009) Barbara Onnis et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
- (2009) Kasper M.A. Rouschop et al. JOURNAL OF CLINICAL INVESTIGATION
- Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel
- (2009) Changxing Liu et al. JOURNAL OF CONTROLLED RELEASE
- MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
- (2009) T. Moriyama et al. MOLECULAR CANCER THERAPEUTICS
- TGFβ-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
- (2009) B Wang et al. ONCOGENE
- Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
- (2009) A Soeda et al. ONCOGENE
- HIF2 inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
- (2009) J. A. Bertout et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Stem Cells, Hypoxia and Metastasis
- (2009) Richard P. Hill et al. SEMINARS IN RADIATION ONCOLOGY
- hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells
- (2008) Lei Shi et al. BRAIN RESEARCH
- Effects of lentivirus-mediated HIF-1α knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells
- (2008) J Hao et al. CANCER GENE THERAPY
- Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance
- (2008) N. Chan et al. CANCER RESEARCH
- Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
- (2008) J. Chiche et al. CANCER RESEARCH
- A microRNA component of the hypoxic response
- (2008) R Kulshreshtha et al. CELL DEATH AND DIFFERENTIATION
- hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
- (2008) C. Camps et al. CLINICAL CANCER RESEARCH
- A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
- (2008) Ulrike Burk et al. EMBO REPORTS
- miR-21 plays a pivotal role in gastric cancer pathogenesis and progression
- (2008) Zhiyu Zhang et al. LABORATORY INVESTIGATION
- The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
- (2008) Qihong Huang et al. NATURE CELL BIOLOGY
- The role of oxygen availability in embryonic development and stem cell function
- (2008) M. Celeste Simon et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- MicroRNA-373 induces expression of genes with complementary promoter sequences
- (2008) R. F. Place et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia Enhances Tumor Stemness by Increasing the Invasive and Tumorigenic Side Population Fraction
- (2008) Bikul Das et al. STEM CELLS
- Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche
- (2007) Yoshiaki Kubota et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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