Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Tumor pH and metastasis: a malignant process beyond hypoxia

(2019) Oliver Thews et al.   CANCER AND METASTASIS REVIEWS

Novel approaches for designing drugs that interfere with pH regulation

(2019) Emanuela Berrino et al.   Expert Opinion on Drug Discovery

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH

(2019) Annasofia Anemone et al.   CANCER AND METASTASIS REVIEWS

New trends in glioma cancer therapy: Targeting Na+ /H + exchangers

(2019) Omid Reza Tamtaji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disturbances in H+ dynamics during environmental carcinogenesis

(2019) Dominique Lagadic-Gossmann et al.   BIOCHIMIE

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms

(2019) Mohammed Albatany et al.   JOURNAL OF NEURO-ONCOLOGY

Targeting tumor-associated acidity in cancer immunotherapy

(2018) Ruben Lacroix et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide

(2018) Mohammed Albatany et al.   International Journal of Clinical Oncology

Anticancer Properties of Fenofibrate: A Repurposing Use

(2018) Xin Lian et al.   Journal of Cancer

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo

(2018) Shen-Han Lee et al.   BRITISH JOURNAL OF CANCER

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

(2018) Jesús Devesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging

(2018) Mohammed Albatany et al.   INVESTIGATIONAL NEW DRUGS

Mutual influence of ROS, pH and CLIC1 membrane protein in the regulation of G1/S phase progression in human glioblastoma stem cells

(2018) Marta Peretti et al.   MOLECULAR CANCER THERAPEUTICS

CEST-MRI for glioma pH quantification in mouse model: Validation by immunohistochemistry

(2018) Giuseppe Ferrauto et al.   NMR IN BIOMEDICINE

Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

(2018) Xiudong Guan et al.   Cell Death & Disease

Systems analysis of intracellular pH vulnerabilities for cancer therapy

(2018) Erez Persi et al.   Nature Communications

Pantoprazole Induces Mitochondrial Apoptosis and Attenuates NF-κB Signaling in Glioma Cells

(2018) Khamushavalli Geeviman et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

(2018) Xiudong Guan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected by Caudal Regression Syndrome

(2017) Jesús Devesa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vivo evaluation of tumour acidosis for assessing the early metabolic response and onset of resistance to dichloroacetate by using magnetic resonance pH imaging

(2017) Annasofia Anemone et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors

(2017) Elisabetta Iessi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

(2017) Katsuyuki Kusuzaki et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Intracellular pH measured by 31 P-MR-spectroscopy might predict site of progression in recurrent glioblastoma under antiangiogenic therapy

(2017) Katharina J. Wenger et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla

(2017) Mohammed Albatany et al.   JOURNAL OF NEURO-ONCOLOGY

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

(2017) Aya Sato et al.   JOURNAL OF NEURO-ONCOLOGY

DDIS-14. THE EFFECT OF BETULINIC ACID ON TEMOZOLOMIDE-RESISTANT GLIOBLASTOMA CELLS

(2017) Wei-Lun Lo et al.   NEURO-ONCOLOGY

Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism

(2017) Kévin Hardonnière et al.   SEMINARS IN CANCER BIOLOGY

Triple-edged therapy targeting intracellular alkalosis and extracellular acidosis in cancer

(2017) Tomas Koltai   SEMINARS IN CANCER BIOLOGY

Targeting pH regulating proteins for cancer therapy–Progress and limitations

(2017) Scott K. Parks et al.   SEMINARS IN CANCER BIOLOGY

Physical and biological characteristics of multi drug resistance (MDR): An integral approach considering pH and drug resistance in cancer

(2017) Ziad Omran et al.   SEMINARS IN CANCER BIOLOGY

Focal photodynamic intracellular acidification as a cancer therapeutic

(2017) Matthew J. Gdovin et al.   SEMINARS IN CANCER BIOLOGY

“ The new pH-centric anticancer paradigm in Oncology and Medicine ” ; SCB, 2017

(2017) Salvador Harguindey et al.   SEMINARS IN CANCER BIOLOGY

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases

(2017) Salvador Harguindey et al.   SEMINARS IN CANCER BIOLOGY

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Glioblastoma-synthesized G-CSF and GM-CSF contribute to growth and immunosuppression: Potential therapeutic benefit from dapsone, fenofibrate, and ribavirin

(2017) Richard E Kast et al.   TUMOR BIOLOGY

Chemotherapy with cisplatin: insights into intracellular pH and metabolic landscape of cancer cells in vitro and in vivo

(2017) Marina V. Shirmanova et al.   Scientific Reports

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+exchanger isoform 1

(2016) Wen Zhu et al.   CARCINOGENESIS

Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas

(2016) Vera Miranda-Goncalves et al.   CURRENT CANCER DRUG TARGETS

Long-term safety of growth hormone replacement therapy after childhood medulloblastoma and PNET: it is time to set aside old concerns

(2016) Alice Indini et al.   JOURNAL OF NEURO-ONCOLOGY

Topiramate induces acute intracellular acidification in glioblastoma

(2016) Kamini Marathe et al.   JOURNAL OF NEURO-ONCOLOGY

Cancer: fundamentals behind pH targeting and the double-edged approach

(2016) Tomas Koltai   OncoTargets and Therapy

PPARα, a predictor of patient survival in glioma, inhibits cell growth through the E2F1/miR-19a feedback loop

(2016) Yan Shi et al.   Oncotarget

Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding

(2016) Cung Hoa Thien Quach et al.   PLoS One

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

(2016) Shikha Srivastava et al.   Scientific Reports

Fenofibrate suppressed proliferation and migration of human neuroblastoma cells via oxidative stress dependent of TXNIP upregulation

(2015) Cunjin Su et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?

(2015) Pierre Besson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Proton channels and exchangers in cancer

(2015) Enrico Pierluigi Spugnini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Ion Transporters in Brain Tumors

(2015) Damin Cong et al.   CURRENT MEDICINAL CHEMISTRY

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

(2015) Edgar Pérez-Herrero et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Growth hormone and cancer: GH production and action in glioma?

(2015) Robert W. Lea et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors

(2015) Quincy Siu-Chung Chu et al.   INVESTIGATIONAL NEW DRUGS

Metronomic chemotherapy with daily low-dose temozolomide and celecoxib in elderly patients with newly diagnosed glioblastoma multiforme: a retrospective analysis

(2015) Grit Welzel et al.   JOURNAL OF NEURO-ONCOLOGY

pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

(2015) Robert J. Harris et al.   NEURO-ONCOLOGY

Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine

(2015) Nevin McVicar et al.   NMR IN BIOMEDICINE

Fenofibrate induces G0/G1 phase arrest by modulating the PPARα/FoxO1/p27kip pathway in human glioblastoma cells

(2015) Dong-feng Han et al.   TUMOR BIOLOGY

Cancer as a channelopathy: ion channels and pumps in tumor development and progression

(2015) Alisa Litan et al.   Frontiers in Cellular Neuroscience

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells

(2015) Dongfeng Han et al.   Oncotarget

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma

(2015) Andrea Di Cristofori et al.   Oncotarget

Voltage-gated sodium channels and cancer: is excitability their primary role?

(2015) Sébastien Roger et al.   Frontiers in Pharmacology

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.

(2015) Richard E. Kast et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Upregulation of NHE1 protein expression enables glioblastoma cells to escape TMZ-mediated toxicity via increased H+extrusion, cell migration and survival

(2014) Damin Cong et al.   CARCINOGENESIS

New celecoxib multiparticulate systems to improve glioblastoma treatment

(2014) M. Vera et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells

(2014) Emanuela Binello et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular Mechanisms of Fenofibrate-Induced Metabolic Catastrophe and Glioblastoma Cell Death

(2014) Anna Wilk et al.   MOLECULAR AND CELLULAR BIOLOGY

P17.07 * FENOFIBRATE AS A NOVEL THERAPEUTIC ADJUVANT FOR TARGETING GLIOMA STEM CELLS

(2014) E. Binello et al.   NEURO-ONCOLOGY

Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma

(2014) Mikaela Porkholm et al.   PEDIATRIC BLOOD & CANCER

Ion channels in cancer: future perspectives and clinical potential

(2014) F. Lang et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Ion channels and transporters in tumour cell migration and invasion

(2014) A. Schwab et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Remodelling of Ca2+ transport in cancer: how it contributes to cancer hallmarks?

(2014) N. Prevarskaya et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review

(2013) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors

(2013) E. M. Dunbar et al.   INVESTIGATIONAL NEW DRUGS

Prospective Safety Surveillance of GH-Deficient Adults: Comparison of GH-Treated vs Untreated Patients

(2013) Mark L. Hartman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

(2013) Salvador Harguindey et al.   Journal of Translational Medicine

Nonsteroidal Anti-inflammatory Drugs Diclofenac and Celecoxib Attenuates Wnt/β-Catenin/Tcf Signaling Pathway in Human Glioblastoma Cells

(2013) Gangadhara Reddy Sareddy et al.   NEUROCHEMICAL RESEARCH

Na+-H+ Exchanger, pH Regulation and Cancer

(2013) Stephan J. Reshkin et al.   Recent Patents on Anti-Cancer Drug Discovery

Involvement of tumor acidification in brain cancer pathophysiology

(2013) Avinash Honasoge et al.   Frontiers in Physiology

Exploiting Cyclooxygenase-(in)Dependent Properties of COX-2 Inhibitors for Malignant Glioma Therapy

(2012) Axel H. Schonthal   Anti-Cancer Agents in Medicinal Chemistry

Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro

(2012) Anna Wilk et al.   CELL CYCLE

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

(2012) Sridhar R. Chirasani et al.   INTERNATIONAL JOURNAL OF CANCER

ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARα -mediated inhibition of Glioma cell motility in vitro

(2012) Justyna Drukala et al.   Molecular Cancer

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

(2012) Vera Miranda-Gonçalves et al.   NEURO-ONCOLOGY

31P and1H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan

(2012) Kavindra Nath et al.   NMR IN BIOMEDICINE

Potential Role of Sodium-Proton Exchangers in the Low Concentration Arsenic Trioxide-Increased Intracellular pH and Cell Proliferation

(2012) Carmen Aravena et al.   PLoS One

Engineering the Regenerative Microenvironment with Biomaterials

(2012) Jeffrey J. Rice et al.   Advanced Healthcare Materials

Effect of celecoxib on proliferation, apoptosis, and survivin expression in human glioma cell line U251

(2012) Ren Zhou et al.   Chinese Journal of Cancer

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

(2011) M. Fujita et al.   CANCER RESEARCH

Targeting glioma stem cells: A novel framework for brain tumors

(2011) Emanuela Binello et al.   CANCER SCIENCE

Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience

(2011) Johannes E. Wolff et al.   JOURNAL OF NEURO-ONCOLOGY

The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-κB pathway

(2011) Gangadhara Reddy Sareddy et al.   JOURNAL OF NEURO-ONCOLOGY

COX-2 regulates the proliferation of glioma stem like cells

(2011) Vivek Sharma et al.   NEUROCHEMISTRY INTERNATIONAL

An integral approach to the etiopathogenesis of human neurodegenerative diseases (HNDDs) and cancer. Possible therapeutic consequences within the frame of the trophic factor withdrawal syndrome (TFWS)

(2011) Salvador Harguindey   Neuropsychiatric Disease and Treatment

Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas

(2010) William Harley et al.   BRAIN RESEARCH

Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells

(2010) Kuan-Hsuan Chen et al.   CHILDS NERVOUS SYSTEM

Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma

(2010) Florian Stockhammer et al.   JOURNAL OF NEURO-ONCOLOGY

Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma

(2010) Tobias Walbert et al.   JOURNAL OF NEURO-ONCOLOGY

Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects

(2010) Hsin-I Ma et al.   JOURNAL OF NEUROSURGERY

Hormona de crecimiento: acciones y aplicaciones preventivas y terapéuticas

(2010) Jesús Devesa et al.   MEDICINA CLINICA

Antiangiogenic Activities of 2,5-Dimethyl-Celecoxib on the Tumor Vasculature

(2010) J. J. Virrey et al.   MOLECULAR CANCER THERAPEUTICS

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy

(2009) Khong Kang et al.   Molecular Cancer

Biomaterials for promoting brain protection, repair and regeneration

(2009) Gorka Orive et al.   NATURE REVIEWS NEUROSCIENCE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

An Unexpected Role for Ion Channels in Brain Tumor Metastasis

(2008) Harald Sontheimer   EXPERIMENTAL BIOLOGY AND MEDICINE

The Contribution of Growth Hormone to Mammary Neoplasia

(2008) Jo K. Perry et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

TRAIL-mediated apoptosis in malignant glioma cells is augmented by celecoxib through proteasomal degradation of survivin

(2008) T. Gaiser et al.   NEUROSCIENCE LETTERS

Regulation of pH in the mammalian central nervous system under normal and pathological conditions: Facts and hypotheses

(2007) Marta Obara et al.   NEUROCHEMISTRY INTERNATIONAL