Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis

(2019) Rajashekhar Kanchanapally et al.   International Journal of Nanomedicine

Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin

(2019) Caijun Dong et al.   OncoTargets and Therapy

Effects of exosomes on pre-metastatic niche formation in tumors

(2019) Yaxin Guo et al.   Molecular Cancer

The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

(2019) Elisa Carrasco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia differentially regulates estrogen receptor alpha in 2D and 3D culture formats

(2019) Nathan A. Whitman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

A Complex Scenario and Underestimated Challenge: The Tumor Microenvironment, ER Stress, and Cancer Treatment

(2018) Oleg I. Chen et al.   CURRENT MEDICINAL CHEMISTRY

Extracellular vesicles as mediators of the progression and chemoresistance of pancreatic cancer and their potential clinical applications

(2018) Jiangdong Qiu et al.   Molecular Cancer

Therapeutic developments in pancreatic cancer: current and future perspectives

(2018) John P. Neoptolemos et al.   Nature Reviews Gastroenterology & Hepatology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

(2018) David Novo et al.   Nature Communications

Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward

(2017) Mohammad Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

(2017) Patricia Dauer et al.   PANCREATOLOGY

Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells

(2017) Priya Samuel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1

(2017) Xialian Xu et al.   TRANSPLANTATION

Chemoresistance in pancreatic cancer: Emerging concepts

(2017) Manu Gnanamony et al.   Oncology Letters

Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease

(2017) Julie V. Philley et al.   Oncotarget

Hypoxia regulates ABCG2activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells

(2016) Xiaodan He et al.   CANCER BIOLOGY & THERAPY

Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype

(2016) Ling Li et al.   CANCER RESEARCH

MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin

(2016) Arun Bhardwaj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer

(2016) Yulin Sun et al.   Scientific Reports

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

MYB is a novel regulator of pancreatic tumour growth and metastasis

(2015) Sanjeev K Srivastava et al.   BRITISH JOURNAL OF CANCER

PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival

(2015) Hongying Gang et al.   JOURNAL OF CELL BIOLOGY

High Expression of HIF1a Is a Predictor of Clinical Outcome in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA, VEGF, and bFGF

(2015) Andreas-Claudius Hoffmann et al.   NEOPLASIA

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells

(2013) Thomas A. Mace et al.   JOURNAL OF SURGICAL RESEARCH

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights into pancreatic cancer biology

(2012) M. Hidalgo   ANNALS OF ONCOLOGY

Molecular Pathology of Pancreatic Cancer: From Bench-to-Bedside Translation

(2012) Vincenzo Corbo et al.   CURRENT DRUG TARGETS

Autocrine stimulation of clear-cell renal carcinoma cell migration in hypoxia via HIF-independent suppression of thrombospondin-1

(2012) Raquel Bienes-Martínez et al.   Scientific Reports

Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation

(2011) C. Polytarchou et al.   CANCER RESEARCH

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

(2011) Douglas D. Taylor et al.   Seminars in Immunopathology

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas

(2009) T. R. Burton et al.   JOURNAL OF NEUROSCIENCE

Hypoxia in Static and Dynamic 3D Culture Systems for Tissue Engineering of Bone

(2008) Elias Volkmer et al.   TISSUE ENGINEERING PART A