Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo

(2013) Y. Bao et al.   MOLECULAR CANCER RESEARCH

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

PrognoScan: a new database for meta-analysis of the prognostic value of genes

(2009) Hideaki Mizuno et al.   BMC Medical Genomics

Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

(2009) H Harada et al.   BRITISH JOURNAL OF CANCER

The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation

(2009) Takuhiko Wakamatsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Relapse-Related Molecular Signature in Lung Adenocarcinomas Identifies Patients With Dismal Prognosis

(2009) Shuta Tomida et al.   JOURNAL OF CLINICAL ONCOLOGY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis

(2008) Lihua Zeng et al.   CANCER SCIENCE

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY