Tumor‐derived exosomes (TDEs): How to avoid the sting in the tail

Exosomes in Inflammation and Inflammatory Disease

(2019) Brandon Dow Chan et al.   PROTEOMICS

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Knockdown of Rab7a suppresses the proliferation, migration and xenograft tumor growth of breast cancer cells

(2018) Jiming Xie et al.   BIOSCIENCE REPORTS

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

A Ca2+-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

(2018) Scott W. Messenger et al.   JOURNAL OF CELL BIOLOGY

NLRP3 Inflammasome Activation Inhibitors in Inflammation-Associated Cancer Immunotherapy: An Update on the Recent Patents

(2018) Spandana R. Kopalli et al.   Recent Patents on Anti-Cancer Drug Discovery

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

(2018) Amrita Datta et al.   Scientific Reports

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

(2018) James Monypenny et al.   Cell Reports

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

(2018) Yiting Wang et al.   Frontiers in Pharmacology

ISG15 in cancer: Beyond ubiquitin-like protein

(2018) Hye Gyeong Han et al.   CANCER LETTERS

Functional implications of Rab27 GTPases in Cancer

(2018) Zhihong Li et al.   Cell Communication and Signaling

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

From Inflammasome to Exosome—Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

(2018) Wojciech Cypryk et al.   Frontiers in Immunology

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

(2018) Zaira Boussadia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of the NLRP3 inflammasome in cancer

(2018) Maryam Moossavi et al.   Molecular Cancer

Aging, inflammation and cancer

(2018) Barbara Bottazzi et al.   SEMINARS IN IMMUNOLOGY

Endothelial Rab7 GTPase mediates tumor growth and metastasis in lysosomal acid lipase–deficient mice

(2017) Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet microvesicles in health and disease

(2017) Imene Melki et al.   PLATELETS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

(2017) Zhiyun Wei et al.   Nature Communications

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

Exosomes maintain cellular homeostasis by excreting harmful DNA from cells

(2017) Akiko Takahashi et al.   Nature Communications

Pediatric brain tumor cells release exosomes with a miRNA repertoire that differs from exosomes secreted by normal cells

(2017) Ágota Tűzesi et al.   Oncotarget

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Armed Exosomes Deliver Proapoptotic Signals to Tumor Site

(2016) L. Rivoltini et al.   CLINICAL CANCER RESEARCH

Emerging Opportunities and Challenges in Cancer Immunotherapy

(2016) T. L. Whiteside et al.   CLINICAL CANCER RESEARCH

Targeting regulatory T cells in tumors

(2016) Chang Liu et al.   FEBS Journal

Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humansin vitro

(2016) Quan Rao et al.   HEPATOLOGY

The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients

(2016) Lisa König et al.   HUMAN IMMUNOLOGY

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages

(2016) Elina Välimäki et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages

(2016) Yuehui Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment

(2016) K.-S.N. Atretkhany et al.   PHARMACOLOGY & THERAPEUTICS

Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes

(2016) Geetanjali Kharmate et al.   PLoS One

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

The Potential of HLA-G-Bearing Extracellular Vesicles as a Future Element in HLA-G Immune Biology

(2016) Vera Rebmann et al.   Frontiers in Immunology

Low pH increases the yield of exosome isolation

(2015) Jae-Jun Ban et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of HLA-G and extracellular vesicles in renal cancer stem cell-induced inhibition of dendritic cell differentiation

(2015) Cristina Grange et al.   BMC CANCER

Biology and immunology of cancer stem(-like) cells in head and neck cancer

(2015) Xu Qian et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Inhibition of Oncogenic Epidermal Growth Factor Receptor Kinase Triggers Release of Exosome-like Extracellular Vesicles and Impacts Their Phosphoprotein and DNA Content

(2015) Laura Montermini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Glioma-derived extracellular vesicles selectively suppress immune responses

(2015) Justin E. Hellwinkel et al.   NEURO-ONCOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Human Tumor-Derived Exosomes Down-Modulate NKG2D Expression

(2014) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

(2014) L. Strauss et al.   JOURNAL OF IMMUNOLOGY

Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

(2014) Dhafer Mrizak et al.   JNCI-Journal of the National Cancer Institute

Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression

(2014) Joshua J. Steffan et al.   PLoS One

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

(2014) Cristina Federici et al.   PLoS One

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

(2014) Marie Lundholm et al.   PLoS One

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

In vivo identification of an HLA-G complex as ubiquitinated protein circulating in exosomes

(2013) Estibaliz Alegre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51

(2013) Tohru Yamamori et al.   FEBS LETTERS

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies

(2013) Jeong M. Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monosodium Urate Activates Src/Pyk2/PI3 Kinase and Cathepsin Dependent Unconventional Protein Secretion From Human Primary Macrophages

(2013) Elina Välimäki et al.   MOLECULAR & CELLULAR PROTEOMICS

Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization

(2013) Zsuzsanna Szatmári et al.   MOLECULAR BIOLOGY OF THE CELL

Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

(2013) James R. Edgar et al.   TRAFFIC

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine

(2011) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

Serum Soluble HLA-E in Melanoma: A New Potential Immune-Related Marker in Cancer

(2011) Mathilde Allard et al.   PLoS One

Increasing vaccine potency through exosome antigen targeting

(2011) Zachary C. Hartman et al.   VACCINE

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

(2010) Anne M. Friel et al.   BREAST CANCER RESEARCH AND TREATMENT

Inflammation-mediated promotion of invasion and metastasis

(2010) Graziella Solinas et al.   CANCER AND METASTASIS REVIEWS

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

HLA-E and HLA-G Expression in Classical HLA Class I-Negative Tumors Is of Prognostic Value for Clinical Outcome of Early Breast Cancer Patients

(2010) E. M. de Kruijf et al.   JOURNAL OF IMMUNOLOGY

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

(2010) Sophie Viaud et al.   JOURNAL OF IMMUNOTHERAPY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Tumor-Derived Microvesicles Induce, Expand and Up-Regulate Biological Activities of Human Regulatory T Cells (Treg)

(2010) Marta Szajnik et al.   PLoS One

αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells

(2010) Parameswaran G. Sreekumar et al.   PLoS One

Functional Reconstitution of ESCRT-III Assembly and Disassembly

(2009) Suraj Saksena et al.   CELL

Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells

(2009) Estrella Mariel Levy et al.   Innate Immunity

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways

(2008) N. Tiwari et al.   BLOOD

Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells

(2008) J. Klibi et al.   BLOOD

MHC independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models

(2008) Jung-ah Cho et al.   CANCER LETTERS

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

(2008) I. S. Zeelenberg et al.   CANCER RESEARCH

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

T Regulatory Type 1 Cells in Squamous Cell Carcinoma of the Head and Neck: Mechanisms of Suppression and Expansion in Advanced Disease

(2008) C. Bergmann et al.   CLINICAL CANCER RESEARCH

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression

(2008) Christoph Bergmann et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma

(2008) Daniel H. Palmer et al.   HEPATOLOGY

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

(2008) N. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE