Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)

Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111

(2016) Carrie L. Lomelino et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of carbonic anhydrase in the pathogenesis of vascular calcification in humans

(2015) María M. Adeva-Andany et al.   ATHEROSCLEROSIS

Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

(2015) Brian P. Mahon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties

(2015) Cenzo Congiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity

(2015) Cenzo Congiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors

(2015) Jekaterina Ivanova et al.   CHEMICAL COMMUNICATIONS

Discovery of novel inhibitors for the treatment of glaucoma

(2015) Kishore Cholkar et al.   Expert Opinion on Drug Discovery

Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions

(2015) Werner E. G. Müller et al.   FEBS Journal

The Warburg effect: Evolving interpretations of an established concept

(2015) Xiaozhuo Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure–Activity Relationships of Glucosyl-Based Sulfamates

(2015) Brian P. Mahon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacotherapy of Glaucoma

(2015) Doreen Schmidl et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Targeting Carbonic Anhydrase IX Activity and Expression

(2015) Brian Mahon et al.   MOLECULES

Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

(2015) Melissa A. Pinard et al.   Biomed Research International

Expression of Hypoxic Marker Carbonic Anhydrase IX Predicts Poor Prognosis in Resectable Hepatocellular Carcinoma

(2015) Wei-Ju Huang et al.   PLoS One

New Insights into Carbonic Anhydrase Inhibition, Vasodilation, and Treatment of Hypertensive-Related Diseases

(2014) Erik R. Swenson   CURRENT HYPERTENSION REPORTS

Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates

(2014) Janina Moeker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

(2014) Abdullah Ozkok et al.   Biomed Research International

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors

(2014) Olga Sedlakova   Frontiers in Physiology

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

(2014) Mayank Aggarwal et al.   IUCrJ

Sulfonamide cross-reactivity: Is there evidence to support broad cross-allergenicity?

(2013) N. R. Wulf et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases

(2013) Melissa A. Pinard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies

(2013) Murat Bozdag et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modulation of the Initial Mineralization Process of SaOS-2 Cells by Carbonic Anhydrase Activators and Polyphosphate

(2013) Xiaohong Wang et al.   CALCIFIED TISSUE INTERNATIONAL

Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures

(2013) Eva Ruusuvuori et al.   EMBO JOURNAL

Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

(2013) Murielle Mimeault et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3− CD4+ CD25− T cells

(2013) Kenichirou Mori et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: Implications for biological assembly and inhibitor development

(2012) Ewa S. Pilka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Carbonic anhydrase IX as a target for metastatic disease

(2012) Roben G. Gieling et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Characterization of human carbonic anhydrase XII stability and inhibitor binding

(2012) Vaida Jogaitė et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights towards sulfonamide drug specificity in α-carbonic anhydrases

(2012) Mayank Aggarwal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure, function and applications of carbonic anhydrase isozymes

(2012) Md. Imtaiyaz Hassan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

(2012) Mayank Aggarwal et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Drug discovery: Chemical beauty contest

(2012) Paul Leeson   NATURE

CAXII Is a Sero-Diagnostic Marker for Lung Cancer

(2012) Makoto Kobayashi et al.   PLoS One

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Catalysis and pH Control by Membrane-associated Carbonic Anhydrase IX in MDA-MB-231 Breast Cancer Cells

(2011) Ying Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

(2010) Chong Yoo et al.   Radiation Oncology

Antibody-specific detection of CAIX in breast and prostate cancers

(2009) Ying Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Short, Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II

(2009) Balendu Sankara Avvaru et al.   BIOCHEMISTRY

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target

(2009) Giuseppina De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

(2009) J K J Ahlskog et al.   BRITISH JOURNAL OF CANCER

Rational drug design

(2009) Soma Mandal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

(2009) V. Alterio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives

(2008) Sally-Ann Poulsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

The Development of Topically Acting Carbonic Anhydrase Inhibitors as Antiglaucoma Agents

(2008) Claudiu Supuran et al.   CURRENT PHARMACEUTICAL DESIGN

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide

(2008) Anna Di Fiore et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS