Targeting cancer stem cells from a metabolic perspective

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

(2019) Petra Jagust et al.   Frontiers in Pharmacology

Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

(2019) Bai Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

(2019) Mohamed Elbadawy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling

(2019) Koen A. Marijt et al.   Journal for ImmunoTherapy of Cancer

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

(2018) Bela Ozsvari et al.   Aging-US

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

(2018) Ernestina M. De Francesco et al.   BIOCHEMICAL JOURNAL

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism

(2018) Marco Fiorillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Targeting Glutamine Metabolism for Cancer Treatment

(2018) Yeon-Kyung Choi et al.   Biomolecules & Therapeutics

Nuclear translocation of PKM2/AMPK complex sustains cancer stem cell populations under glucose restriction stress

(2018) Yi-Chieh Yang et al.   CANCER LETTERS

Metabolic traits of cancer stem cells

(2018) Joana Peixoto et al.   Disease Models & Mechanisms

Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors

(2018) Sergey Malchenko et al.   Oncotarget

Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling

(2018) Maria Peiris-Pagès et al.   Oncotarget

Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4)

(2018) Abhijeet Deshmukh et al.   Cancers

A mitochondrial based oncology platform for targeting cancer stem cells (CSCs): MITO-ONC-RX

(2018) Federica Sotgia et al.   CELL CYCLE

Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study

(2018) Paola Caria et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin C counteracts miR-302/367-induced reprogramming of human breast cancer cells and restores their invasive and proliferative capacity

(2018) Bahareh Ramezankhani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Redox regulation of cell state and fate

(2018) Bernice Woon Li Lee et al.   Redox Biology

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

Isolation, identification, and characterization of cancer stem cells: A review

(2017) Mohammad Reza Abbaszadegan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

(2017) Daniela Massihnia et al.   Journal of Hematology & Oncology

Multidrug resistance in glioblastoma stem-like cells: Role of the hypoxic microenvironment and adenosine signaling

(2017) Daniel Uribe et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

(2017) Jianwei Liao et al.   Molecular Cancer

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

(2017) Xiuxing Wang et al.   NATURE NEUROSCIENCE

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

(2017) Ernestina Marianna De Francesco et al.   Oncotarget

Hallmarks of cancer stem cell metabolism

(2016) Patricia Sancho et al.   BRITISH JOURNAL OF CANCER

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

(2016) Chia-Lin Chen et al.   Cell Metabolism

Cancer stem cell metabolism: a potential target for cancer therapy

(2016) Abhijeet Deshmukh et al.   Molecular Cancer

Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

(2016) Samuel N. Rodman et al.   RADIATION RESEARCH

Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism

(2016) Bisrat G. Debeb et al.   Oncotarget

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

(2016) Masakazu Sato et al.   Oncotarget

Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines

(2015) Yasmin M. Attia et al.   BMC CANCER

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells

(2015) ZhengMing Wu et al.   Cell Stem Cell

Hypoxia-inducible factors in cancer stem cells and inflammation

(2015) Gong Peng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

(2015) Rebecca Lamb et al.   Oncotarget

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122

(2015) Kyoungsub Song et al.   Oncotarget

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

(2015) Corti Denise et al.   Oncotarget

Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism

(2015) Nicole Gordon et al.   Stem Cell Research & Therapy

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

The paradigm of mutant p53-expressing cancer stem cells and drug resistance

(2014) Yoav Shetzer et al.   CARCINOGENESIS

Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

(2014) Yao-An Shen et al.   CELL CYCLE

Targeting proapoptotic protein BAD inhibits survival and self-renewal of cancer stem cells

(2014) K S R Sastry et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

(2014) I Vega-Naredo et al.   CELL DEATH AND DIFFERENTIATION

Ovarian tumor-initiating cells display a flexible metabolism

(2014) Angela S. Anderson et al.   EXPERIMENTAL CELL RESEARCH

Clinical impact of the Warburg effect in gastrointestinal cancer (Review)

(2014) HIROSHI SAWAYAMA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Tackling the cancer stem cells — what challenges do they pose?

(2014) Diwakar R. Pattabiraman et al.   NATURE REVIEWS DRUG DISCOVERY

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

Control of glioma cell death and differentiation by PKM2–Oct4 interaction

(2014) M Morfouace et al.   Cell Death & Disease

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

(2013) Annegret Kathagen et al.   ACTA NEUROPATHOLOGICA

Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells

(2013) Shaobin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Cancer as a metabolic disease: implications for novel therapeutics

(2013) T. N. Seyfried et al.   CARCINOGENESIS

The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells

(2013) JAVIER MENENDEZ et al.   CELL CYCLE

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

(2013) Yao-An Shen et al.   Evidence-based Complementary and Alternative Medicine

Energy Metabolism Characterization of a Novel Cancer Stem Cell-Like Line 3AB-OS

(2013) Roberta Palorini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism

(2013) Luke Gammon et al.   PLoS One

The regulation of cellular metabolism by tumor suppressor p53

(2013) Yingjian Liang et al.   Cell and Bioscience

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

(2011) Xiao-Qun Ye et al.   INTERNATIONAL JOURNAL OF CANCER

LY294002 and Metformin Cooperatively Enhance the Inhibition of Growth and the Induction of Apoptosis of Ovarian Cancer Cells

(2011) Cuilan Li et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death

(2011) C Wanka et al.   ONCOGENE

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of Mitochondrial Membrane Potential: A Novel Tool to Isolate and Identify Cancer Stem Cells from a Tumor Mass?

(2010) Xiao-Qun Ye et al.   Stem Cell Reviews and Reports

Role of Oxidative Stress in Stem, Cancer, and Cancer Stem Cells

(2010) Ahmed Abdal Dayem et al.   Cancers

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

(2008) Kazuhito Naka et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Metabolism Modulates Differentiation and Teratoma Formation Capacity in Mouse Embryonic Stem Cells

(2008) Stefan M. Schieke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY

Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem Cells

(2007) Gabriele Saretzki et al.   STEM CELLS